Drug-mediated induction of cytochrome(s) P-450 and drug metabolism in cultured hepatocytes maintained in chemically defined medium.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Microsomes and drug oxidation

1969 • 451 citations

PARENCHYMAL CELLS FROM ADULT RAT LIVER IN NONPROLIFERATING MONOLAYER CULTURE

1973 • 427 citations

Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition.

1975 • 303 citations

Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance

1977 • 265 citations

Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448.

1976 • 262 citations

Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital.

1976 • 229 citations

Drug Metabolism in Adult Rat Hepatocytes in Primary Monolayer Culture

1977 • 226 citations

[18] Isolation of Rough and Smooth Microsomes—General

1974 • 181 citations

Maintenance of cytochrome P-450 and metabolism of aflatoxin B1 in primary hepatocyte cultures

1977 • 178 citations

Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process.

1977 • 160 citations

The influence of phenobarbital on the turnover of hepatic microsomal cytochrome b5 and cytochrome P-450 hemes in the rat

1970 • 129 citations

Independent Genetic Control of the Catalytic Activity and the Rate of Degradation of Catalase in Mice

1969 • 126 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds.

1975 • 109 citations

Biphasic Decrease of Radioactive Hemoprotein from Liver Microsomal CO-binding Particles

1969 • 105 citations

Apparent lack of correlation between the loss of cytochrome P-450 in hepatic parenchymal cell culture and the stimulation of haem oxygenase activity

1978 • 102 citations

Chemically Induced Porphyria: Increased Microsomal Heme Turnover after Treatment with Allylisopropylacetamide

1971 • 99 citations

Cytochrome P-450 Induction by Phenobarbital and 3-Methylcholanthrene in Primary Cultures of Hepatocytes

1976 • 93 citations

Purification of liver microsomal cytochrome P-448 from 3-methylcholanthrene-treated rabbits.

1975 • 83 citations

Multiplicity of cytochrome P-450 hemoproteins in rat liver microsomes. Preparation and specificity of an antibody to the hemoprotein induced by phenobarbital.

1975 • 81 citations

Hormonal requirements for the induction of cytochrome P450 in hepatocytes cultured in a serum-free medium

1979 • 78 citations

Resolution of two forms of cytochrome P-450 from liver microsomes of rabbit treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1977 • 78 citations

A sensitive radiometric assay of aminopyrine N-demethylation.

1973 • 75 citations

Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.

1977 • 75 citations

Effects of Phenobarbital, 3-Methylcholanthrene, and Hematin on the Synthesis of Protein Components of Rat Liver Microsomal Membranes

1972 • 75 citations

Snythesis and differentiation of plasma proteins in cultured embryonic chicken liver cells: a system for study of regulation of protein synthesis.

1975 • 59 citations

Aryl Hydrocarbon Hydroxylase Induction in Mammalian Liver Cell Culture

1972 • 58 citations

Microsomal Hydroxylase Induction in Liver Cell Culture by Phenobarbital, Polycyclic Hydrocarbons, and p , p ′-DDT

1971 • 56 citations

Structural resemblance of cytochrome P-450 isolated from Pseudomonas putida and from rabbit liver microsomes

1974 • 53 citations

Drug stimulation of -aminolevulinic acid synthetase and cytochrome P-450 in vivo in chick embryo liver.

1973 • 51 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures

1976 • 39 citations

Interaction of chemical carcinogens and drug-metabolizing enzymes in primary cultures of hepatic cells from the rat.

1976 • 37 citations

Chlorcyclizine N-demethylase activity in chick embryo hepatic cell culture

1973 • 7 citations

[Dose-dependent effects on phenobarbital on microsomal liver enzymes of chicken embryos (author's transl)].

1977 • 1 citations