Mammary fibroblasts stimulate growth, alveolar morphogenesis, and functional differentiation of normal rat mammary epithelial cells

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Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components

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Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse

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Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities

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Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.

1995 • 304 citations

The comparative pathology of human and mouse mammary glands.

1999 • 243 citations

Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells

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Regulation of mammary gland growth and morphogenesis by the mammary fat pad: a species comparison.

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1982 • 213 citations

Regulation of Mammary Epithelial Cell Growth in Mice and Rats*

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Mechanism of Estrogen Action: Lessons from the Estrogen Receptor-α Knockout Mouse1

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New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionally.

1989 • 180 citations

HGF/SF: a potent cytokine for mammary growth, morphogenesis and development

1995 • 171 citations

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1998 • 166 citations

Conjugated Linoleic Acid Inhibits Proliferation and Induces Apoptosis of Normal Rat Mammary Epithelial Cells in Primary Culture

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1983 • 159 citations

Glycosaminoglycans in the basal lamina and extracellular matrix of the developing mouse mammary duct

1982 • 149 citations

Growth Factor- and Cyclic Nucleotide-Induced Proliferation of Normal and Malignant Mammary Epithelial Cells in Primary Culture*

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Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis.

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ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network

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New Aspects of Stroma-Parenchyma Relations in Mammary Gland Differentiation

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Inhibins and activins regulate mammary epithelial cell differentiation through mesenchymal-epithelial interactions

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1986 • 117 citations

Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation.

1991 • 115 citations

Adult, foetal and transformed fibroblasts display different migratory phenotypes on collagen gels: Evidence for an isoformic transition during foetal development

1985 • 114 citations

Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli.

1996 • 112 citations

Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor.

1994 • 111 citations

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Dual origin of mesenchymal tissues participating in mouse mammary gland embryogenesis

1982 • 110 citations

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1983 • 110 citations

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1979 • 106 citations

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The Insulin-Like Growth Factors (IGF) and IGF Type I Receptor during Postnatal Growth of the Murine Mammary Gland: Sites of Messenger Ribonucleic Acid Expression and Potential Functions**This work was supported, in part, by NIH Grant DK-48103 (to T.L.W.)

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3T3-L1 Adipocytes promote the growth of mammary epithelium

1984 • 81 citations

Estrogen Responsiveness of Normal Mouse Mammary Cells in Primary Cell Culture: Association of Mammary Fibroblasts with Estrogeiiic Regulation of Progesterone Receptors*

1985 • 78 citations

Topographical arrangement of basement membrane proteins in lactating rat mammary gland: comparison of the distribution of type IV collagen, laminin, fibronectin, and Thy-1 at the ultrastructural level.

1983 • 75 citations

Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels

1985 • 75 citations

Abnormal properties of skin fibroblasts from patients with breast cancer

1984 • 75 citations

Milk protein expression and ductal morphogenesis in the mammary gland in vitro: Hormone-dependent and -independent phases of adipocyte-mammary epithelial cell interaction

1987 • 73 citations

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1992 • 72 citations

Rat mammary preadipocytes in culture produce a trophic agent for mammary epithelia—prostaglandin E₂

1984 • 71 citations

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FIBROBLASTS FROM PATIENTS WITH BREAST CANCER SHOW ABNORMAL MIGRATORY BEHAVIOUR IN VITRO

1984 • 70 citations

Growth of normal and neoplastic mouse mammary epithelial cells in primary culture: stimulation by conditioned medium from mouse mammary fibroblasts.

1983 • 67 citations

Mitogenic activity of neu differentiation factor/heregulin mimics that of epidermal growth factor and insulin‐like growth factor‐I in human mammary epithelial cells

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Adipocyte–Epithelial Interactions Regulate thein VitroDevelopment of Normal Mammary Epithelial Cells

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Capacity of Mammary Fat Pads of Adult C3H/HeMs Mice To Interact Morphogenetically With Fetal Mammary Epithelium2

1979 • 61 citations

Different growth factors stimulate cell division of rat mammary epithelial, myoepithelial, and stromal cell lines in culture

1984 • 61 citations

FIBROBLASTS FROM RELATIVES OF PATIENTS WITH HEREDITARY BREAST CANCER SHOW FETAL-LIKE BEHAVIOUR IN VITRO

1987 • 60 citations

Control of Growth and Differentiation of the Mammary Gland by Growth Factors

1991 • 59 citations

Primary culture of normal rat mammary epithelial cells within a basement membrane matrix. I. Regulation of proliferation by hormones and growth factors

1990 • 58 citations

Three-dimensional mammary primary culture model systems

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Participation of two different mesenchymes in the developing mouse mammary gland: synthesis of basement membrane components by fat pad precursor cells

1985 • 57 citations

Modulation of Hepatocyte Growth Factor and c-met in the Rat Mammary Gland during Pregnancy, Lactation, and Involution

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Mammary organoids from immature virgin rats undergo ductal and alveolar morphogenesis when grown within a reconstituted basement membrane*1

1991 • 54 citations

Mammary Stroma Modulates Hormonal Responsiveness of Mammary Epithelium in Vivo in the Mouse*

1991 • 53 citations

Importance of extended growth potential and growth factor independence on in vivo neoplastic potential of primary rat mammary carcinoma cells.

1987 • 51 citations

Primary culture of normal rat mammary epithelial cells within a basement membrane matrix. II. Functional differentiation under serum-free conditions

1990 • 48 citations

Keratinocyte Growth Factor and Acidic Fibroblast Growth Factor Are Mitogens for Primary Cultures of Mammary Epithelium

1994 • 48 citations

Synthesis of basic fibroblast growth factor upon differentiation of rat mammary epithelial to myoepithelial‐like cells in culture

1990 • 44 citations

Ontogeny and epithelial–stromal interactions regulate IGF expression in the ovine mammary gland

1998 • 43 citations

Developmental response of adult mammary epithelial cells to various fetal and neonatal mesenchymes.

1992 • 42 citations

Prolactin and epidermal growth factor regulation of the proliferation, morphogenesis, and functional differentiation of normal rat mammary epithelial cells in three dimensional primary culture

1995 • 41 citations

Distribution of entactin in the basement membrane of the rat mammary gland

1984 • 41 citations

Hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), and their receptors in human breast cells and tissues: alternative receptors.

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Induction of the endogenous whey acidic protein (Wap) gene and a Wap-myc hybrid gene in primary murine mammary organoids

1990 • 40 citations

The basement‐membrane‐like matrix of the mouse EHS tumor: I. Ultrastructure

1985 • 35 citations

Prostaglandin production in mouse mammary tumour cells confers invasive growth potential by inducing hepatocyte growth factor in stromal fibroblasts

1999 • 34 citations

Expression of epidermal growth factor-related proteins in the aged adult mouse mammary gland and their relationship to tumorigenesis

1997 • 34 citations

Hydrocortisone and progesterone regulation of the proliferation, morphogenesis, and functional differentiation of normal rat mammary epithelial cells in three dimensional primary culture

1995 • 32 citations

Alterations in the expression and localization of protein kinase C isoforms during mammary gland differentiation

1999 • 27 citations

Quantitative variation of proto‐oncogene and cytokine gene expression in isolated breast fibroblasts

1995 • 25 citations

Heterogeneity of fibroblast response in host‐tumor cell‐cell interactions in metastatic tumors

1987 • 23 citations

Growth of mouse mammary epithelium in response to serum-free media conditioned by mammary adipose tissue

1988 • 22 citations

Selective changes in EGF receptor expression and function during the proliferation, differentiation and apoptosis of mammary epithelial cells

1999 • 22 citations

Mammary Fibroblast-derived Hepatocyte Growth Factor and Mammogenic Hormones Stimulate the Growth of Mouse Mammary Epithelial Cells in Primary Culture.

1999 • 21 citations

Transformed growth phenotype of mouse mammary epithelium in primary culture induced by specific fetal mesenchymes

1992 • 21 citations

Expression of messenger RNA for insulin-like growth factors and insulin-like growth factor binding proteins by experimental breast cancer and normal breast tissue in vivo.

1992 • 20 citations

Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland

1991 • 20 citations

Normal but Not Carcinomatous Primary Rat Mammary Epithelium: Readily Transplanted to and Maintained in the Athymic Nude Mouse<xref ref-type="fn" rid="FN2">2</xref>

1987 • 20 citations

Stimulation of thymidine uptake and cell proliferation in mouse embryo fibroblasts by conditioned medium from mammary cells in culture.

1976 • 17 citations

Immunolocalization and expression of insulin-like growth factor I (IGF-I) in the mammary gland during rat gestation and lactation

1994 • 16 citations

Serum-free primary culture of normal mouse mammary epithelial and stromal cells

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Phosphatidylinositol 3-kinase mediates heregulin-induced growth inhibition in human epithelial cells.

1997 • 13 citations

Epithelium — Mesenchyme Interaction in the Fetal Mammary Gland

1987 • 12 citations

Proliferation of Ductal Outgrowths by Carcinogen-Induced Rat Mammary Tumors in Gland-Free Mammary Fat Pads<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 10 citations

Identification and Partial Characterization of Mesenchyme-Derived Growth Factor That Stimulates Proliferation and Inhibits Functional Differentiation of Mouse Mammary Epithelium in Culture.

1989 • 9 citations

Coculture Inserts Possess an Intrinsic Ability to Alter Growth Regulation of Human Breast Cancer Cells

1994 • 9 citations

Intrinsic differences in the transplantability and outgrowth potential of DMBA‐induced rat mammary tumors

1989 • 5 citations

Morphogenesis in mammary gland cell cultures Occurrence of tubular structures in combined cultures of fibroblastic and normal epithelial cells

1981 • 4 citations