Endogenous Opioid Peptides and Hypothalamo-Pituitary Function

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone

1977 • 579 citations

HORMONAL AND METABOLIC RESPONSES TO AN ENKEPHALIN ANALOGUE IN NORMAL MAN

1978 • 354 citations

Endocrine Effects of Naloxone-Induced Opiate Receptor Blockade *

1980 • 301 citations

The endocrinology of the opiates and opioid peptides

1981 • 291 citations

Evidence for Paracrine Interaction between Gonadotrophs and Lactotrophs in Pituitary Cell Aggregates*

1983 • 268 citations

Enkephalin analogues and naloxone modulate the release of growth hormone and prolactin - evidence for regulation by an endogenous opioid peptide in brain

1977 • 251 citations

Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons

1979 • 234 citations

Endogenous Opiates Modulate Pulsatile Luteinizing Hormone Release in Humans*

1981 • 228 citations

Effect of Sex Steroids on β-Endorphin in Hypophyseal Portal Blood*

1982 • 209 citations

EFFECTS OF MORPHINE ON SERUM GROWTH HORMONE, CORTISOL, PROLACTIN AND THYROID STIMULATING HORMONE IN MAN

1975 • 202 citations

β-Endorphin in Hypophyseal Portal Blood: Variations throughout the Menstrual Cycle*

1982 • 181 citations

CENTRAL DISTRIBUTION OF OPIOID PEPTIDES

1983 • 173 citations

β-Endorphin and dynorphin control serum luteinizing hormone level in immature female rats

1981 • 167 citations

THE OPIOID CONTROL OF LH AND FSH RELEASE: EFFECTS OF A MET-ENKEPHALIN ANALOGUE AND NALOXONE

1981 • 165 citations

Opiate Receptors Modulate LHRH and SRIF Release from Mediobasal Hypothalamic Neurons

1981 • 161 citations

Multiple opiate receptors in peripheral tissue preparations

1981 • 150 citations

The Effects of Estrogen and Progestin on Endogenous Opioid Activity in Oophorectomized Women*

1985 • 138 citations

Release of beta endorphin and met-enkephalin during exercise in normal women: response to training.

1984 • 135 citations

Differential Effects of Opiate Peptides and Alkaloids on Anterior Pituitary Hormone Secretion

1983 • 134 citations

Naloxone inhibition of stress-induced increase in prolactin secretion

1978 • 134 citations

Opiatergic Control of Gonadotropin Secretion during Puberty in the Rat: A Neurochemical Basis for the Hypothalamic ‘Gonadostat?’*

1983 • 117 citations

Levels of Dynorphin-(1–13) Immunoreactivity in Rat Neurointermediate Pituitaries Are Concomitantly Altered with Those of Leucine Enkephalin and Vasopressin in Response to Various Endocrine Manipulations

1981 • 107 citations

EVIDENCE FOR DECREASED ENDOGENOUS DOPAMINE AND OPIOID INHIBITORY INFLUENCES ON LH SECRETION IN POLYCYSTIC OVARY SYNDROME

1984 • 104 citations

Evidence for an Increased Opioid Inhibition of Luteinizing Hormone Secretion in Hyperprolactinemic Patients with Pituitary Microadenoma*

1980 • 103 citations

OPIATE MEDIATION OF AMENORRHOEA IN HYPERPROLACTINAEMIA AND IN WEIGHT‐LOSS RELATED AMENORRHOEA

1982 • 99 citations

Effect of Endogenous Opioid Blockade on the Amplitude and Frequency of Pulsatile Luteinizing Hormone Secretion in Normal Men*

1982 • 97 citations

Progestins Increase Endogenous Opioid Peptide Activity in Postmenopausal Women*

1985 • 88 citations

INHIBITION OF VASOPRESSIN RELEASE IN MAN BY AN OPIATE PEPTIDE

1980 • 83 citations

beta-Endorphin and met-enkephalins: their distribution, modulation by estrogens and haloperidol, and role in neuroendocrine control.

1980 • 82 citations

Fasting impairs LH secretion in female rats by activating an inhibitory opioid pathway

1985 • 82 citations

Iontophoresis of Morphine into the Arcuate Nucleus: Effects on Dopamine Concentrations in Hypophysial Portal Plasma and Serum Prolactin Concentrations*

1981 • 81 citations

NALOXONE INHIBITS EXERCISE‐INDUCED RELEASE OF PRL AND GH IN ATHLETES

1983 • 80 citations

OPIOID REGULATION OF PROLACTIN SECRETION: EVIDENCE FOR A SPECIFIC ROLE OF β-ENDORPHIN

1981 • 75 citations

Opioid peptides have found their roots

1982 • 75 citations

Lack of Modulation of Pituitary Hormone Stress Response by Neural Pathways Involving Opiate Receptors*

1980 • 71 citations

Failure of naloxone to influence physiological growth hormone and prolactin secretion

1979 • 71 citations

Evidence for Endogenous Opioid Control of Vasopressin Release in Man

1980 • 71 citations

DO TESTICUIAR OPIATES REGULATE LEYDIG CELL FUNCTION?

1984 • 69 citations

The Role of Endogenous Opiates in the Mechanism of Inhibited Luteinizing Hormone (LH) Secretion in Women with Anorexia Nervosa: The Effect of Naloxone on LH, Follicle-Stimulating Hormone, Prolactin, and β-Endorphin Secretion*

1984 • 67 citations

Pituitary somatotrophs contain [Met]enkephalin-like immunoreactivity.

1978 • 66 citations

Naloxone Has a Direct Effect on the Adrenal Cortex*

1981 • 58 citations

THE EFFECT OF NALOXONE ON PULSATILE GONADOTROPHIN RELEASE IN NORMAL SUBJECTS

1981 • 57 citations

Evidence for Hypothalamic Noradrenergic Involvement in Naloxone-Induced Stimulation of Luteinizing Hormone Release

1981 • 57 citations

Simultaneous Pulsatile Release of Prolactin and Luteinizing Hormone Induced by Luteinizing Hormone-Releasing Factor Agonist*

1981 • 52 citations

A Noninvasive Functional Lesion of the Hypothalamo-Pituitary Axis for the Study of Growth Hormone-Releasing Factor

1983 • 51 citations

Reduction by β-endorphin of efflux of dopamine and dopac from superfused medial basal hypothalamus

1980 • 50 citations

EPINEPHRINE SYNTHESIS INHIBITORS BLOCK NALOXONE-INDUCED LH RELEASE

1982 • 49 citations

Failure of Naloxone to Influence Plasma Growth Hormone, Prolactin, and Cortisol Secretions Induced by Insulin Ilypoglycemia*

1980 • 49 citations

Naloxone-Induced Prolactin Secretion in Women: Evidence against a Direct Prolactin Stimulatory Effect of Endogenous Opioids*

1985 • 47 citations

Responsiveness of Gonadotropin Secretion to Infusion of an Opiate-Receptor Antagonist in Hypogonadotropic Individuals*

1982 • 46 citations

Changes in pituitary hormone levels induced by met-enkephalin in man—The role of dopamine

1981 • 40 citations

Effects of Naloxone on Prolactin, Luteinizing Hormone, and Cortisol Responses to Surgical Stress in Humans

1982 • 38 citations

OPIATE PEPTIDES CONTROL GROWTH HORMONE THROUGH A CHOLINERGIC MECHANISM IN MAN

1983 • 36 citations

Participation of Endogenous Opiates in Regulation of the Hypothalamic-Pituitary-Testicular Axis in Normal Men*

1983 • 33 citations

Effect of Naloxone on Pituitary Hypersecretory Syndromes*

1982 • 28 citations

Relationship between endogenous opioids and the oestrous cycle in the rat

1984 • 25 citations

PROLONGED ELEVATION OF HYPOTHALAMIC OPIOID PEPTIDE ACTIVITY IN WOMEN TAKING ORAL CONTRACEPTIVES

1984 • 24 citations

NALOXONE INCREASES THE NICOTINE‐STIMULATED RISE OF VASOPRESSIN SECRETION IN MAN

1982 • 22 citations

THE ROLE OF OPIATE PEPTIDES IN THE CONTROL OF PROLACTIN IN THE PUERPERIUM, AND TSH IN PRIMARY HYPOTHYROIDISM

1982 • 21 citations

FAILURE OF NALOXONE TO ALTER GROWTH HORMONE AND PROLACTIN LEVELS IN ACROMEGALIC AND IN HYPERPROLACTINAEMIC PATIENTS

1979 • 20 citations

Concomitant neonatal development and in vitro release of dynorphin and α-neo-endorphin

1982 • 18 citations

EFFECTS OF HIGH‐DOSE AND LOW‐DOSE NALOXONE ON PLASMA ACTH IN PATIENTS WITH ACTH HYPERSECRETION

1985 • 16 citations

‘Dynorphin’ in plasma: enzymatic artifact and authentic immunoreactivity

1984 • 15 citations

Doα-Adrenergic Mechanisms Regulate Spontaneous or Opiate-Modulated Pulsatile Luteinizing Hormone Secretion in Man?*

1983 • 13 citations