The Pulmonary Uptake, Accumulation, and Metabolism of Xenobiotics

A Sensitive Fluorimetric Assay for Serum Angiotensin-con venrting Enzyme

1976 • 462 citations

Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung

1977 • 359 citations

The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study.

1978 • 326 citations

Evidence for energy-dependent accumulation of paraquat into rat lung

1974 • 294 citations

Biochemical and metabolic changes in the lung with oxygen, ozone, and nitrogen dioxide toxicity.

1978 • 247 citations

Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude

1975 • 209 citations

Lung injury induced by butylated hydroxytoluene: cytodynamic and biochemical studies in mice.

1977 • 186 citations

Correlation of paraquat toxicity with tissue concentrations and weight loss of the rat

1972 • 184 citations

Cytochrome P-450: Localization in Rabbit Lung

1980 • 179 citations

Removal of 5‐hydroxytryptamine in the pulmonary circulation of rat isolated lungs

1970 • 159 citations

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital on the occurrence and distribution of four cytochrome P-450 isozymes in rabbit kidney, lung, and liver.

1982 • 128 citations

Effects of isolation and culture on prostaglandin synthesis by porcine aortic endothelial and smooth muscle cells

1982 • 120 citations

The pulmonary clara cell as a target for toxic chemicals requiring metabolic activation; studies with carbon tetrachloride.

1980 • 110 citations

Drug absorption from the lung

1978 • 108 citations

Absorption of aerosolized drugs from the rat lung.

1983 • 106 citations

Accumulation of amines in the isolated perfused rabbit lung.

1974 • 98 citations

The accumulation of putrescine into slices of rat lung and brain and its relationship to the accumulation of paraquat

1981 • 90 citations

Primary Pulmonary Responses to Toxic Agents

1977 • 78 citations

Hypothermic inhibition of 5-hydroxytryptamine and norepinephrine uptake by lung: cellular location of amines after uptake.

1973 • 78 citations

Species and strain differences in target organ alkylation and toxicity by 4-ipomeanol

1979 • 76 citations

New aspects of the toxicology and pharmacology of pyrrolizidine alkaloids

1979 • 76 citations

The accumulation of diamines and polyamines into rat lung slices

1982 • 68 citations

A study of the dynamics of imipramine accumulation in the isolated perfused rabbit lung.

1975 • 67 citations

ALTERED REMOVAL OF VASOACTIVE SUBSTANCES IN THE INJURED LUNG: DETECTION OF LUNG MICROVASCULAR INJURY*

1982 • 62 citations

Relation between molecular weight and pulmonary absorption rate of lipid-insoluble compounds in neonatal and adult rats

1983 • 61 citations

1,1-Dichloroethylene-Induced Pulmonary Injury

1982 • 60 citations

Structural Bases for Metabolic Activity

1982 • 60 citations

Metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in chicken aortas: Monooxygenation, bioactivation to mutagens, and covalent binding to DNA in vitro

1980 • 55 citations

Pulmonary endothelial dysfunction in the presence or absence of interstitial injury induced by intratracheally injected bleomycin in rabbits.

1983 • 48 citations

Phenol red absorption from the rat lung: Evidence of carrier transport

1973 • 47 citations

Pulmonary Metabolism of Prostaglandins and Vasoactive Peptides

1982 • 46 citations

The relationship between the catalytic activities of rabbit pulmonary cytochrome P-450 isozymes and the lung-specific toxicity of the furan derivative, 4-ipomeanol.

1982 • 46 citations

Cellular structure, function and organization in the lower respiratory tract.

1984 • 45 citations

Prostaglandin synthetase and cytochrome P-450-dependent metabolism of (+/-)benzo(a)pyrene 7,8-dihydrodiol by enriched populations of rat Clara cells and alveolar type II cells.

1983 • 44 citations

Toxicology of trialkylphosphorothioates with particular reference to lung toxicity

1984 • 43 citations

Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations.

1974 • 41 citations

Ubiquitous binding of benzo[a]pyrene metabolites to DNA and protein in tissues of the mouse and rabbit

1984 • 40 citations

METABOLISM OF PHENYLETHYLAMINE IN RAT ISOLATED PERFUSED LUNG: EVIDENCE FOR MONOAMINE OXIDASE ‘TYPE B’ IN LUNG

1976 • 39 citations

Assay of peptidase and protease enzymes in vivo

1983 • 37 citations

Metabolism of [3H]benzoyl-phenylalanyl-alanyl-proline by pulmonary angiotensin converting enzyme in vivo: effects of bradykinin, SQ 14225 or acute hypoxia.

1981 • 35 citations

Simple Radioassay for Measuring Serum Activity of Angiotensin-Converting Enzyme in Sarcoidosis

1980 • 32 citations

The accumulation of polyamines and paraquat by human peripheral lung

1983 • 30 citations

Absorption of Disodium Cromoglycate from the Rat Lung: Evidence of Carrier Transport

1974 • 30 citations

Studies on the persistence of basic amines in the rabbit lung.

1979 • 29 citations

Covalent binding of metabolites of 4-ipomeanol to rabbit pulmonary and hepatic microsomal proteins and to the enzymes of the pulmonary cytochrome P-450-dependent monooxygenase system.

1983 • 28 citations

Active transport of phenol red by rat lung slices.

1976 • 26 citations

Comparison of pulmonary and extrapulmonary extraction of biogenic amines

1982 • 25 citations

Effect of oxygen exposure on lung clearance of amines

1978 • 24 citations

The relationship between right duct lymph flow and extravascular lung water in dogs given alpha-naphthylthiourea.

1976 • 23 citations

Pneumotoxic effects of thiobenzamide derivatives

1982 • 22 citations

Chlorphentermine binding in rat lung subcellular fractions and its displacement by desmethylimipramine

1979 • 22 citations

Effects of chlorphentermine and phentermine on the pulmonary disposition of 5-hydroxytryptamine in the rat in vivo.

1983 • 21 citations

The prediction of benzo[a]pyrene clearance by rat liver and lung from enzyme kinetic data.

1983 • 20 citations

Metabolism of the normal cardiovascular wall. 2. The pentose phosphate pathway

1962 • 19 citations

The Effect of High Concentrations of Oxygen on Paraquat and Diquat Toxicity in Rats

1980 • 19 citations

Metabolic interactions of hydrocarbons with mammalian lung.

1981 • 17 citations

CHARACTERIZATION OF (±)‐METHADONE UPTAKE BY RAT LUNG

1977 • 14 citations

Oxygen-induced lung toxicity: Effect on serotonin disposition and metabolism

1982 • 14 citations

Flow dependence of norepinephrine extraction by isolated perfused rat lungs

1982 • 13 citations

Absorption of paraquat and diquat from the airways of the perfused rat lung

1978 • 13 citations

Prolonged reduction in serum angiotensin converting enzyme activity after treatment of rabbits with bleomycin

1983 • 13 citations

Impairment in pulmonary bioenergetics following chlorphentermine administration to rats

1983 • 12 citations

Alveolar epithelium transport of albumin and sucrose: concentration difference effect

1979 • 12 citations

Pulmonary absorption of drugs in the neonatal rat

1978 • 11 citations

Lymphatic transport of inhaled diesel particles in the lungs of rats and guinea pigs exposed to diluted diesel exhaust

1981 • 11 citations

Superoxide dismutase and pulmonary ozone toxicity

1977 • 10 citations

Paths of Hydrophilic Solute Flow Across Excised Bullfrog Lung

1982 • 9 citations

Mechanism of pulmonary absorption of quaternary ammonium compounds in the rat.

1983 • 8 citations

Effect of Thyroxine on Permeability of the Neonatal Rat Lung to Drugs

1978 • 8 citations

Ultrastructural changes in intraacinar pulmonary veins. Relationship to 3-methylindole-induced acute pulmonary edema and pulmonary arterial changes in cattle.

1984 • 8 citations

Effect of Cortisone on Permeability of the Neonatal Rat Lung to Drugs

1981 • 6 citations

Sex comparison of pulmonary absorption of drugs in the rat.

1983 • 5 citations

A compartmental model for the uptake of chlorphentermine in isolated perfused rat lung

1981 • 3 citations