Chronic Obstructive Pulmonary Disease: Risk Factors, Pathophysiology and Pathogenesis

Pathologic Changes in the Peripheral Airways of Young Cigarette Smokers

1974 • 959 citations

The Relations between Structural Changes in Small Airways and Pulmonary-Function Tests

1978 • 851 citations

The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center.

1979 • 473 citations

Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers.

1983 • 462 citations

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.

1981 • 441 citations

Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans

1979 • 398 citations

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.

1982 • 352 citations

Single breath diffusing capacity in a representative sample of the population of Michigan, a large industrial state. Predicted values, lower limits of normal, and frequencies of abnormality by smoking history.

1983 • 255 citations

Human Alveolar Macrophage-derived Chemotactic Factor for Neutrophils

1980 • 253 citations

Reassessment of inflammation of airways in chronic bronchitis.

1985 • 217 citations

Chronic Airflow Obstruction in Lung Disease.

1977 • 199 citations

The National Institutes of Health Intermittent Positive-Pressure Breathing trial: pathology studies. II. Correlation between morphologic findings, clinical findings, and evidence of expiratory air-flow obstruction.

1985 • 126 citations

Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies.

1986 • 122 citations

Lung disease in long-term cigarette smokers with and without chronic air-flow obstruction.

1984 • 115 citations

The functional activity of α1-proteinase inhibitor in bronchoalveolar lavage fluids from healthy human smokers and non-smokers

1983 • 83 citations

Exponential analysis of the lung pressure-volume curve as a predictor of pulmonary emphysema.

1982 • 75 citations

Human Neutrophil Elastase Does not Bind to Alpha₁-Protease Inhibitor that Has Been Exposed to Activated Human Neutrophils

1983 • 71 citations

The National Institutes of Health Intermittent Positive-Pressure Breathing trial: pathology studies. I. Interrelationship between morphologic lesions.

1985 • 68 citations

Acute effect of smoking on the functional activity of alpha1-protease inhibitor in bronchoalveolar lavage fluid.

1985 • 68 citations

THE MEASUREMENT OF THE INTRAPLEURAL PRESSURE IN MAN AND ITS SIGNIFICANCE

1934 • 61 citations

Role of alpha-macroglobulin-elastase complexes in the pathogenesis of elastase-induced emphysema in hamsters.

1982 • 48 citations

Experimental chronic bronchitis.

1983 • 43 citations

Cigarette Smoke Inhalation Potentiates Elastase-induced Emphysema in Hamsters^1–3

1983 • 41 citations

Session 1: Epidemiology of COPD State of the Art

1984 • 41 citations

Elastic recoil changes in early emphysema.

1980 • 40 citations

Proteolytic Activity of Human Neutrophil Elastase and Porcine Pancreatic Trypsin Causes Bronchial Secretory Cell Metaplasia in Hamsters

1985 • 37 citations

Mechanisms of Lung Injury in the Copper-Deficient Hamster Model of Emphysema

1984 • 32 citations

Detection of antileukoprotease in connective tissue of the lung

1986 • 31 citations

Emphysema associated with intravascular leukocyte sequestration. Comparison with papain-induced emphysema.

1981 • 30 citations

Acid-induced secretory cell metaplasia in hamster bronchi

1988 • 25 citations

The Epidemiology of Emphysema

1983 • 24 citations

Small Airways Disease in Patients without Chronic Air-Flow Limitation

1987 • 21 citations

Emphysema Induced by Intravenously Administered Endotoxin in an Alpha₁-Antitrypsin-Deficient Rat Model

1984 • 19 citations

The mechanisms that limit expiratory flow

1980 • 17 citations

Serum studies of leucocyte elastase in acute and chronic lung diseases.

1982 • 14 citations

Affixment arrangements of peribronchiolar alveoli in normal and emphysematous lungs.

1982 • 7 citations