Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study

The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease

2004 • 3,761 citations

The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease

2004 • 3,455 citations

Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease

2007 • 3,107 citations

The St George's Respiratory Questionnaire

1991 • 2,582 citations

Antibiotic Therapy in Exacerbations of Chronic Obstructive Pulmonary Disease

1987 • 2,382 citations

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

2012 • 2,003 citations

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

2009 • 1,797 citations

A measure of quality of life for clinical trials in chronic lung disease.

1987 • 1,692 citations

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

2009 • 1,320 citations

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

2011 • 938 citations

Reslizumab for Poorly Controlled, Eosinophilic Asthma

2011 • 682 citations

Effect of an Inhaled Corticosteroid on Airway Inflammation and Symptoms in Asthma

1992 • 654 citations

Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial

2000 • 570 citations

Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease

2012 • 543 citations

Airway eosinophilia in chronic bronchitis during exacerbations.

1994 • 537 citations

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

2013 • 455 citations

Roflumilast—an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial

2005 • 451 citations

Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial

2007 • 437 citations

Inhaled corticosteroids in COPD and the risk of serious pneumonia

2013 • 421 citations

Minimal Clinically Important Differences in Pharmacological Trials

2014 • 414 citations

Sputum Eosinophilia Predicts Benefit from Prednisone in Smokers with Chronic Obstructive Bronchitis

1998 • 394 citations

Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease

2005 • 358 citations

Development and Validation of an Improved, COPD-Specific Version of the St. George Respiratory Questionnaire

2007 • 320 citations

Development of a self-reported Chronic Respiratory Questionnaire (CRQ-SR)

2001 • 265 citations

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma

2010 • 264 citations

Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment

2006 • 256 citations

Effect of fluticasone propionate/salmeterol (250/50μg) or salmeterol (50μg) on COPD exacerbations

2008 • 219 citations

Exacerbation rate, health status and mortality in COPD – a review of potential interventions

2009 • 178 citations

Effect of Fluticasone Propionate/Salmeterol (250/50) on COPD Exacerbations and Impact on Patient Outcomes

2009 • 158 citations

Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis

2014 • 157 citations

Interleukin-5 and Its Receptor System: Implications in the Immune System and Inflammation

1994 • 135 citations

Airway eosinophilia and expression of interleukin‐5 protein in asthma and in exacerbations of chronic bronchitis

1996 • 124 citations

Phenotyping the heterogeneity of chronic obstructive pulmonary disease

2012 • 54 citations

Sputum IL-5 Concentration Is Associated with a Sputum Eosinophilia and Attenuated by Corticosteroid Therapy in COPD

2009 • 52 citations