Alzheimer's - Looking beyond plaques

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

2008 • 1,377 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

1995 • 538 citations

Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway

2003 • 508 citations

Protective effects of NSAIDs on the development of Alzheimer disease

2008 • 487 citations

Isolation of an interleukin‐1‐like factor from human joint effusions

1983 • 450 citations

Interleukin-1 is an astroglial growth factor in the developing brain

1988 • 442 citations

Alzheimer's disease in Down's syndrome

1985 • 393 citations

Purification and characterization of a neurite extension factor from bovine brain.

1985 • 378 citations

Extended results of the Alzheimer's disease anti‐inflammatory prevention trial

2011 • 309 citations

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

2010 • 250 citations

Interleukin-1 mediates Alzheimer and Lewy body pathologies

2006 • 235 citations

Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimerʼs Disease

1996 • 210 citations

Neuronal–Glial Interactions Mediated by Interleukin-1 Enhance Neuronal Acetylcholinesterase Activity and mRNA Expression

2000 • 205 citations

S100β protein expression in Alzheimer disease: Potential role in the pathogenesis of neuritic plaques

1994 • 179 citations

Alzheimer's disease in Down's syndrome: Clinicopathologic studies

2011 • 22 citations

Changes in RNA Synthesis and Messenger RNA Content in the Cerebellum of Rats with Graft Versus Host Disease

1980 • 19 citations

Graft-versus-host disease impairs cerebellar growth

1978 • 14 citations

Manipulation of brain DNA synthesis is achieved by using a systemic immunological disease.

1982 • 6 citations