Enabling a Genetically Informed Approach to Cancer Medicine: A Retrospective Evaluation of the Impact of Comprehensive Tumor Profiling Using a Targeted Next-Generation Sequencing Panel

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

2009 • 7,749 citations

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

2011 • 7,390 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

2007 • 5,137 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study

2011 • 3,882 citations

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

2010 • 3,500 citations

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

2008 • 3,476 citations

Crizotinib versus Chemotherapy in AdvancedALK-Positive Lung Cancer

2013 • 3,211 citations

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

2013 • 1,940 citations

The first 30 years of p53: growing ever more complex

2009 • 1,805 citations

Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

2012 • 821 citations

Genome Sequencing Identifies a Basis for Everolimus Sensitivity

2012 • 667 citations

Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

2012 • 635 citations

MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

2013 • 617 citations

Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory Cancers

2010 • 596 citations

High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing

2011 • 513 citations

Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas

2013 • 448 citations

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

2010 • 392 citations

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

2012 • 377 citations

Phase II Trial of the CDK4 Inhibitor PD0332991 in Patients With AdvancedCDK4-Amplified Well-Differentiated or Dedifferentiated Liposarcoma

2013 • 372 citations

A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors

1998 • 223 citations

Routine Multiplex Mutational Profiling of Melanomas Enables Enrollment in Genotype-Driven Therapeutic Trials

2012 • 195 citations

BRAF L597 Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors

2012 • 192 citations

BRAF Fusions Define a Distinct Molecular Subset of Melanomas with Potential Sensitivity to MEK Inhibition

2013 • 169 citations

Analytical Performance of a Real-time PCR-based Assay for V600 Mutations in the BRAF Gene, Used as the Companion Diagnostic Test for the Novel BRAF Inhibitor Vemurafenib in Metastatic Melanoma

2012 • 145 citations

Dramatic Response Induced by Vemurafenib in a BRAF V600E-Mutated Lung Adenocarcinoma

2013 • 105 citations

Technical and implementation issues in using next-generation sequencing of cancers in clinical practice

2013 • 94 citations

Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies

2014 • 62 citations

Major Clinical Response to a BRAF Inhibitor in a Patient With a BRAF L597R–Mutated Melanoma

2013 • 54 citations

Data mining using the Catalogue of Somatic Mutations in Cancer BioMart

2011 • 50 citations