Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases.

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

LEUKOCYTE LOCOMOTION AND CHEMOTAXIS

1973 • 1,709 citations

Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin.

1980 • 767 citations

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

1985 • 738 citations

Single-step separation of red blood cells, granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque

1974 • 735 citations

THE ENZYMATIC IODINATION OF THE RED CELL MEMBRANE

1972 • 709 citations

Elastase in Tissue Injury

1985 • 512 citations

The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

1985 • 437 citations

Human complement component C3: cDNA coding sequence and derived primary structure.

1985 • 410 citations

Chemotaxis and inflammation

1974 • 397 citations

Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.

1984 • 391 citations

Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin

1985 • 299 citations

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

1979 • 293 citations

Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils.

1984 • 264 citations

Potential Mediator of Inflammation

1980 • 255 citations

Human Alveolar Macrophage-derived Chemotactic Factor for Neutrophils

1980 • 253 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Synthetic peptide with cell attachment activity of fibronectin.

1983 • 248 citations

Proteolysis by Neutrophils

1982 • 244 citations

Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

1980 • 233 citations

Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

1977 • 224 citations

Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes.

1977 • 215 citations

Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase.

1982 • 207 citations

Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions.

1986 • 201 citations

Regulation of arachidonic acid metabolism by macrophage activation.

1982 • 176 citations

C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp.

1987 • 163 citations

Nicotine is Chemotactic for Neutrophils and Enhances Neutrophil Responsiveness to Chemotactic Peptides

1984 • 157 citations

Phagocytosing macrophages exclude proteins from the zones of contact with opsonized targets

1984 • 134 citations

Migration of neutrophils across monolayers of cultured microvascular endothelial cells An in vitro model of leucocyte extravasation

1987 • 121 citations

Neutrophil-mediated solubilization of the subendothelial matrix: oxidative and nonoxidative mechanisms of proteolysis used by normal and chronic granulomatous disease phagocytes.

1986 • 113 citations

Studies on the fibronectin receptors of human peripheral blood leukocytes. Morphologic and functional characterization.

1984 • 111 citations

Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser.

1985 • 111 citations

Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors.

1984 • 96 citations

Alpha-1-antitrypsin-human leukocyte elastase complexes in blood: quantification by an enzyme-linked differential antibody immunosorbent assay and comparison with alpha-2-plasmin inhibitor-plasmin complexes

1983 • 96 citations

Specific binding of soluble fibrin to macrophages.

1977 • 94 citations

Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency.

1986 • 83 citations

Kinetics of Granulocytopoiesis

1979 • 49 citations

The release of elastase, myeloperoxidase, and lysozyme from human alveolar macrophages.

1982 • 32 citations

Substrate hydrolysis by immune complex-activated neutrophils: effect of physical presentation of complexes and protease inhibitors.

1981 • 32 citations

Interactions of neutrophil elastase, serum trypsin inhibitory activity, and smoking history as risk factors for chronic obstructive pulmonary disease in patients with MM, MZ, and ZZ phenotypes for alpha-antitrypsin.

1977 • 24 citations