Secondary Rearrangements and Hypermutation Generate Sufficient B Cell Diversity to Mount Protective Antiviral Immunoglobulin Responses

Somatic generation of antibody diversity

1983 • 3,275 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1993 • 920 citations

Baculovirus Expression Vectors: the Requirements for High Level Expression of Proteins, Including Glycoproteins

1987 • 677 citations

Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system

1997 • 485 citations

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

1991 • 460 citations

B lymphocytes may escape tolerance by revising their antigen receptors.

1993 • 425 citations

Lymphocytic Choriomeningitis Virus

2016 • 423 citations

Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing

1995 • 313 citations

Receptor Editing in a Transgenic Mouse Model: Site, Efficiency, and Role in B Cell Tolerance and Antibody Diversification

1997 • 291 citations

V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes

1997 • 284 citations

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

1997 • 247 citations

Functional analysis of T lymphocyte subsets in antiviral host defense.

1987 • 237 citations

Analysis of Heavy and Light Chain Pairings Indicates that Receptor Editing Shapes the Human Antibody Repertoire

1999 • 220 citations

Editing Disease-Associated Autoantibodies

1997 • 217 citations

Receptor Editing Occurs Frequently during Normal B Cell Development

1998 • 205 citations

A Quasi-Monoclonal Mouse

1996 • 204 citations

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

1995 • 197 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

Monoclonal antibodies to lymphocytic choriomeningitis and pichinde viruses: Generation, characterization, and cross-reactivity with other arenaviruses

1981 • 176 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.

1996 • 152 citations

Thymus dependence of viral antigens

1975 • 145 citations

Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells

1998 • 138 citations

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.

1993 • 134 citations

Protection against lethal viral infection by neutralizing and nonneutralizing monoclonal antibodies: distinct mechanisms of action in vivo

1984 • 133 citations

Self-Reactive B Lymphocytes Overexpressing Bcl-xL Escape Negative Selection and Are Tolerized by Clonal Anergy and Receptor Editing

1998 • 120 citations

V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

1998 • 114 citations

Immune Receptor Editing

1998 • 113 citations

The Role of Somatic Mutation in the Generation of the Protective Humoral Immune Response against Vesicular Stomatitis Virus

1996 • 110 citations

Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D.

1985 • 102 citations

Mechanisms of antibody-mediated protection against lymphocytic choriomeningitis virus infection: mother-to-baby transfer of humoral protection

1992 • 85 citations

Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus.

1986 • 84 citations

Lymphocytic choriomeningitis virus. VI. Isolation of a glycoprotein mediating neutralization

1983 • 83 citations

VH gene replacement in hyperselected B cells of the quasimonoclonal mouse.

1997 • 77 citations

How many specific B cells are needed to protect against a virus?

1994 • 69 citations

Secondary V(D)J recombination in B-1 cells

1999 • 68 citations

The immune response of the mouse to lymphocytic choriomeningitis virus

1983 • 64 citations

Antiviral antibodies attenuate T-cell-mediated immunopathology following acute lymphocytic choriomeningitis virus infection

1991 • 58 citations

T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses

1998 • 54 citations

Induction of Protective Cytotoxic T Cell Responses in the Presence of High Titers of Virus-neutralizing Antibodies: Implications for Passive and Active Immunization

1998 • 50 citations

VH gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice

1998 • 33 citations

Monovalent single‐chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus protect against lethal infection

1996 • 32 citations

The Immune Response of the Mouse to Lymphocytic Choriomeningitis Virus. I. Circulating Antibodies

1979 • 22 citations

Antibodies against the two serotypes of vesicular stomatitis virus measured by enzyme-linked immunosorbent assay: immunodominance of serotype-specific determinants and induction of asymmetrically cross-reactive antibodies

1987 • 18 citations

Mapping of the dominant neutralizing antigenic site of a virus using infected cells

1996 • 12 citations