Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization.

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

2016 • 4,824 citations

The Metabolic Basis of Inherited Disease

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Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Update on Key Emerging Challenges in Cystic Fibrosis

2014 • 3,606 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

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Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

An Animal Model for Cystic Fibrosis Made by Gene Targeting

1992 • 921 citations

Cystic fibrosis: molecular biology and therapeutic implications

1992 • 820 citations

Submucosal glands are the predominant site of CFTR expression in the human bronchus

1992 • 644 citations

Cystic fibrosis: a disease in electrolyte transport

1990 • 510 citations

Endocrine Cells in Human Intestine: An Immunocytochemical Study

1983 • 502 citations

Defective acidification of intracellular organelles in cystic fibrosis

1991 • 490 citations

Immunocytochemical localization of the cystic fibrosis gene product CFTR.

1991 • 419 citations

Cystic fibrosis in adults

1979 • 357 citations

Crypts Are the Site of Intestinal Fluid and Electrolyte Secretion

1982 • 356 citations

Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland

1992 • 354 citations

Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells

1993 • 347 citations

Regulation of Plasma Membrane Recycling by CFTR

1992 • 339 citations

Gastrointestinal Manifestations of Cystic Fibrosis: A Review

1981 • 328 citations

In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator

1991 • 327 citations

Pathology of cystic fibrosis review of the literature and comparison with 146 autopsied cases.

1975 • 322 citations

Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.

1991 • 296 citations

Cystic fibrosis in the mouse by targeted insertional mutagenesis

1992 • 293 citations

Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia

1992 • 225 citations

Prevalence of liver disease in cystic fibrosis.

1991 • 224 citations

Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation

1992 • 214 citations

Identification of the cystic fibrosis gene: Chromosome walking and jumping

1989 • 194 citations

Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA

1989 • 190 citations

Chromogranin: A newly recognized marker for endocrine cells of the human gastrointestinal tract

1985 • 168 citations

Expression of the cystic fibrosis gene in human foetal tissues

1993 • 159 citations

A distinctive type of biliary cirrhosis of the liver associated with cystic fibrosis of the pancreas; recognition through signs of portal hypertension.

1956 • 151 citations

CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents

1993 • 131 citations

Cell-specific localization of CFTR mRNA shows developmentally regulated expression in human fetal tissues

1993 • 122 citations

?Caveolated cells? characterized by deep surface invaginations and abundant filaments in mouse gastro-intestinal epithelia

1974 • 120 citations

Down-regulation of cystic fibrosis gene mRNA transcript levels and induction of the cystic fibrosis chloride secretory phenotype in epithelial cells by phorbol ester

1991 • 94 citations

Regulation of Chloride Transport in Epithelia

1989 • 78 citations

ABNORMAL JEJUNAL POTENTIAL DIFFERENCE IN CYSTIC FIBROSIS

1989 • 54 citations

Localization of cystic fibrosis transmembrane conductance regulator mRNA in human fetal lung tissue by in situ hybridization.

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Cystic fibrosis of the pancreas. Morphologic findings in infants with and without diagnostic pancreatic lesions.

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Bile acid secretion in cystic fibrosis: evidence for a defect unrelated to fat malabsorption.

1986 • 48 citations

The origin of and subcellular mechanisms causing pancreatic bicarbonate secretion

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A new cell type (tuft cell) in the gastrointestinal mucosa of the rat

1973 • 43 citations

Origins of chloride and bicarbonate secretory defects in the cystic fibrosis pancreas, as suggested by pancreatic function studies on control and CF subjects with preserved pancreatic function.

1989 • 42 citations

Induction of expression of the cystic fibrosis transmembrane conductance regulator.

1992 • 41 citations

Regulation of ion transport in porcine gallbladder: effects of VIP and norepinephrine

1989 • 36 citations

An animal model for cystic fibrosis made by gene targeting

1992 • 35 citations

Down-regulation of cystic fibrosis transmembrane conductance regulator gene expression by agents that modulate intracellular divalent cations.

1992 • 34 citations

Radiographic Abnormalities of the Duodenum and Small Bowel in Cystic Fibrosis of the Pancreas (Mucoviscidosis)

1973 • 31 citations

Gallbladder disease in cystic fibrosis

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Altered sulfate transport via anion exchange in CFPAC is corrected by retrovirus-mediated CFTR gene transfer

1992 • 31 citations

Regulation Of Chloride Transport In Epithelia

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Effects of changes in mucosal solution Cl- or K+ concentration on cell water volume of Necturus gallbladder epithelium.

1991 • 20 citations

Cystic Fibrosis in adults. 75 cases and a review of 232 cases in the literature

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Relationship between intestinal function and chloride secretion in patients with cystic fibrosis.

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Colonic transepithelial potential difference in infants with cystic fibrosis

1991 • 15 citations

Down-Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Gene Expression by Agents That Modulate Intracellular Divalent Cations

1992 • 14 citations