Coexpression of Microsomal-Type Prostaglandin E Synthase with Cyclooxygenase-2 in Brain Endothelial Cells of Rats during Endotoxin-Induced Fever

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Fever: Role of Pyrogens and Cryogens

1991 • 1,240 citations

Prostaglandin synthase 2

1996 • 1,212 citations

Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

1999 • 990 citations

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

2000 • 945 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Sickness behavior as a new target for drug development

1992 • 866 citations

A molecular basis for bidirectional communication between the immune and neuroendocrine systems.

1989 • 842 citations

Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis

2000 • 700 citations

Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3

1998 • 677 citations

Cytokine-to-brain communication: A review & analysis of alternative mechanisms

1995 • 579 citations

Prostaglandin and thromboxane biosynthesis

1991 • 444 citations

Cytokines as Endogenous Pyrogens

1999 • 387 citations

New Concepts on the Pathogenesis of Fever

1988 • 373 citations

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

1993 • 348 citations

Translocation of the 85-kDa Phospholipase A2 from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen

1995 • 331 citations

Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever

1996 • 309 citations

Effect of Acute Systemic Inflammatory Response and Cytokines on the Transcription of the Genes Encoding Cyclooxygenase Enzymes (COX‐1 and COX‐2) in the Rat Brain

1998 • 279 citations

Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages

1997 • 279 citations

An Essential Role of Interleukin-1β in Mediating NF-κB Activity and COX-2 Transcription in Cells of the Blood–Brain Barrier in Response to a Systemic and Localized Inflammation But Not During Endotoxemia

1999 • 279 citations

The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2−/−, but not in cyclooxygenase-1−/− mice

1999 • 269 citations

Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response

1995 • 252 citations

Brain Endothelial Cells Express Cyclooxygenase-2 during Lipopolysaccharide-Induced Fever: Light and Electron Microscopic Immunocytochemical Studies

1998 • 245 citations

Growth-related changes in specific mRNAs of cultured mouse cells.

1983 • 209 citations

Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain

1997 • 206 citations

Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide

1996 • 194 citations

Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide

1998 • 168 citations

Fever: How May Circulating Pyrogens Signal the Brain?

1997 • 152 citations

Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression

1995 • 134 citations

Interleukin‐1 receptors on rat brain endothelial cells: a role in neuroimmune interaction?

1996 • 129 citations

Human glutathione dependent prostaglandin E synthase: gene structure and regulation

2000 • 117 citations

Prostaglandin D, E, and F synthases

1995 • 111 citations

Lipopolysaccharide Injected into the Cerebral Ventricle Evokes Fever through Induction of Cyclooxygenase-2 in Brain Endothelial Cells

1999 • 106 citations

Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart

1999 • 104 citations

Cyclooxygenase-2 is induced in brain blood vessels during fever evoked by peripheral or central administration of tumor necrosis factor

1998 • 102 citations

Immunocytochemical detection of prostaglandin E2 in microvasculature and in neurons of rat brain after administration of bacterial endotoxin

1993 • 101 citations

Two Types of Microsomal Prostaglandin E Synthase: Glutathione-Dependent and -Independent Prostaglandin E Synthases

1997 • 88 citations

Prostaglandins in Fever and the Mode of Action of Antipyretic Drugs

1982 • 81 citations

Sixteenth Gaddum Memorial Lecture December 1996. Neuroimmune interactions: the role of cytokines

1997 • 73 citations

Eicosanoid production by rat cerebral endothelial cells: Stimulation by lipopolysaccharide, interleukin-1 and interleukin-6

1995 • 70 citations

NOTICES

1999 • 10 citations