The Regulation of Biosynthesis of Aromatic Amino Acids and Vitamins

The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase

1965 • 248 citations

Hydroxamic Acids in Nature

1967 • 246 citations

Preliminary studies on the isolation and metabolism of an intermediate in aromatic biosynthesis: chorismic acid

1964 • 191 citations

Pathways of biosynthesis of aromatic amino acids and vitamins and their control in microorganisms.

1968 • 187 citations

Suppressor genes for nonsense mutations

1965 • 167 citations

Specialized transduction of tryptophan markers in Escherichia coli K12 by bacteriophage ∅80

1963 • 149 citations

Mutants of Escherichia coli with an Altered Tryptophanyl-Transfer Ribonucleic Acid Synthetase

1968 • 147 citations

Cumulative feedback inhibition in the multiple end product regulation of glutamine synthetase activity in Escherichiacoli

1964 • 147 citations

Effect of α-methylhistidine on the control of histidine synthesis

1964 • 143 citations

REGULATION OF THE ENZYMES OF THE TRYPTOPHAN PATHWAY IN ESCHERICHIA COLI

1965 • 139 citations

False Feedback Inhibition: Inhibition of Tryptophan Biosynthesis by 5-Methyltryptophan

1960 • 138 citations

Isolation and identification of 2,3-dihydroxybenzoic acid and .N2,N6-di(2,3-dihydroxybenzoyl)-L-lysine formed by iron-deficient Azotobacter vinelandii

1969 • 130 citations

Degradation of Tryptophan Messenger: Direction of in vivo Degradation of Tryptophan Messenger RNA–A Correction

1969 • 117 citations

Biosynthesis of Ubiquinone in Escherichia coli K-12: Location of Genes Affecting the Metabolism of 3-Octaprenyl-4-hydroxybenzoic Acid and 2-Octaprenylphenol

1969 • 115 citations

Control of aromatic biosynthesis: The multiplicity of 7-phospho-2-oxo-3-deoxy-d-arabino-heptonate d-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) in Eschetichia coli W

1965 • 113 citations

The biosynthesis of steroids, terpenes, and acetogenins

1965 • 110 citations

Studies on the regulation of tryptophan biosynthesis in Escherichia coli

1965 • 109 citations

The Nature of the Anthranilic Acid Synthetase Complex of Escherichia coli

1966 • 109 citations

A gene cluster in Nuerospora crassa coding for an aggregate of five aromatic synthetic enzymes.

1967 • 108 citations

ROLE OF VALYL-sRNA SYNTHETASE IN ENZYME REPRESSION

1965 • 107 citations

Biologically active compounds containing 2,3-duhydroxybenzoic acid and serine formed by Escherichia coli

1970 • 107 citations

A Multifunctional Enzyme Complex in the Tryptophan Pathway of Salmonella typhimurium: Comparison of Polarity and Pseudopolarity Mutations

1966 • 102 citations

Organization of Enzymes in the Polyaromatic Synthetic Pathway: Separability in Bacteria

1969 • 101 citations

The Control of 3-Deoxy-d-arabino-heptulosonic Acid 7-Phosphate Synthesis by Phenylalanine and Tyrosine

1962 • 100 citations

Control of Aromatic Acid Biosynthesis in Bacillus subtilis : Sequential Feedback Inhibition

1966 • 98 citations

On the transcription of the tryptophan operon in Escherichia coli

1965 • 97 citations

Amino acid substitutions resulting from suppression of nonsense mutations

1965 • 97 citations

Inducibility of tryptophan synthetase in Pseudomonas putida.

1966 • 96 citations

Degradation of Tryptophan Messenger: On the Degradation of Messenger RNA for the Tryptophan Operon in Escherichia coli

1969 • 95 citations

Revised linkage map of Escherichia coli.

1967 • 95 citations

Genetic and Biochemical Analysis of the Isoenzymes Concerned in the First Reaction of Aromatic Biosynthesis in Escherichia coli

1967 • 94 citations

Anthranilate Synthetase, an Enzyme Specified by the Tryptophan Operon of Escherichia coli : Comparative Studies on the Complex and the Subunits

1969 • 93 citations

The regulatory significance of intermediary metabolites: Control of aromatic acid biosynthesis by feedback inhibition in Bacillus subtilis

1965 • 91 citations

Regulator Gene Controlling Enzymes Concerned in Tyrosine Biosynthesis in Escherichia coli

1969 • 90 citations

Comparative Control of a Branch-Point Enzyme in Microorganisms

1967 • 89 citations

Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli

1969 • 89 citations

Amber mutants of the trpR regulatory gene

1969 • 89 citations

Anthranilate Synthetase

1966 • 88 citations

Organization of Enzymes in the Common Aromatic Synthetic Pathway: Evidence for Aggregation in Fungi

1969 • 88 citations

The biosynthesis of steroids, terpenes, and acetogenins

1964 • 86 citations

Anthranilate Synthetase, an Enzyme Specified by the Tryptophan Operon of Escherichia coli : Purification and Characterization of Component I

1969 • 86 citations

Biosynthesis and Conversion of Aromatic Amino Acids in Plants

1969 • 85 citations

The periodicity of RNA polymerase initiations: a new regulatory feature of transcription.

1968 • 83 citations

Regulation der Biosynthese der aromatischen Aminosäuren in Saccharomyces cerevisiae

1967 • 81 citations

The isolation, identification and properties of isochorismic acid. An intermediate in the biosynthesis of 2,3-dihydroxybenzoic acid

1969 • 79 citations

REGULATION OF AROMATIC AMINO ACID BIOSYNTHESIS IN ESCHERICHIA COLI K12

1968 • 78 citations

Anthranilate synthetase. Purification and properties of component I from Salmonella typhimurium

1968 • 78 citations

Regulation of Glutamine Synthetase II. Patterns of Feedback Inhibition in Microorganisms

1967 • 75 citations

Correlation of Genes and Enzymes, and Studies on Regulation of the Aromatic Pathway in Salmonella

1967 • 72 citations

Multiple Molecular Forms of Chorismate Mutase in Bacillus subtillis^*

1967 • 72 citations

Regulatory Enzymes of Aromatic Amino Acid Biosynthesis in Bacillus Subtilis

1966 • 70 citations

Operator mutants of the tryptophan operon in Escherichia coli

1969 • 70 citations

Interference with Feedback Control: a Mechanism of Antimetabolite Action

1959 • 67 citations

On the transcription of the tryptophan operon in Escherichia coli

1965 • 66 citations

Studies on the mechanism of repression of arginine biosynthesis in Escherichia coli

1968 • 66 citations

In vivo and in vitro formation of 2,3-dihydroxybenzoylserine by Escherichia coli K12

1966 • 65 citations

Comparative Regulation of Isoenzymic 3-Deoxy- <scp>d</scp> - arabino -Heptulosonate 7-Phosphate Synthetases in Microorganisms

1968 • 64 citations

Valyl-Transfer RNA: Role in Repression of the Isoleucine-Valine Enzymes in Escherichia coli

1967 • 61 citations

Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium

1969 • 60 citations

Translation of the tryptophan messenger RNA of Escherichia coli.

1968 • 60 citations

End-product regulation of the general aromatic pathway in Escherichia coliW

1963 • 57 citations

Control of three isoenzymic 7-phospho-2-oxo-3-deoxy-d-arabino-heptonate-d-erythrose-4-phosphate lyases of Escherichia coli W and derived mutants by repressive and “inductive” effects of the aromatic amino acids

1966 • 57 citations

Mutant Strains of Escherichia coli K-12 Unable to Form Ubiquinone

1968 • 53 citations

Lipoquinones of Escherichia coli

1966 • 49 citations

An enzyme aggregate in the tryptophan pathway of Neurospora crassa.

1965 • 48 citations

TRYPTOPHANYL TRANSFER RNA SYNTHETASE AND EXPRESSION OF THE TRYPTOPHAN OPERON IN THE trpS MUTANTS OF ESCHERICHIA COLI

1969 • 48 citations

Anthranilate synthetase and PR-transferase from Aerobacter aerogenes as a protein aggregate

1966 • 48 citations

An Enzyme Aggregate Involved in the Biosynthesis of Aromatic Amino Acids in Bacillus subtilis. Its Possible Function in Feedback Regulation^*

1967 • 48 citations

Inhibition of 3-Deoxy- <scp>d</scp> -Arabinoheptulosonic Acid-7-Phosphate Synthetase (trp) in Escherichia coli

1969 • 47 citations

Tryptophan Synthetic Pathway and Its Regulation in Chromobacterium violaceum

1968 • 47 citations

Regulation der Biosynthese der aromatischen Aminosäuren in Claviceps paspali

1967 • 44 citations

Characteristics of the transducing elements of bacteriophage φ80

1964 • 44 citations

Determinants for Regulation and Initiation of Expression of Tryptophan Genes

1966 • 43 citations

Regulation Reversal Mutation: Characterization of End Product-activated Mutants of Bacillus subtilis

1967 • 42 citations

Tryptophan: a Feedback Activator for Chorismate Mutase from Neurospora^*

1966 • 41 citations

A new intermediate in aromatic biosynthesis

1962 • 40 citations

The source of the nitrogen atom for the biosynthesis of anthranilic acid

1964 • 39 citations

Sequential Derepression and Repression of the Tryptophan Operon in E. coil

1968 • 38 citations

Aromatic biosynthesis in yeast

1966 • 38 citations

The isolation, identification and properties of 2,3-dihydro-2,3-dihydroxybenzoic acid. An intermediate in the biosynthesis of 2,3-dihydroxybenzoic acid

1969 • 38 citations

Activation of tyrosine analogs in relation to enzyme repression

1965 • 38 citations

Purification and properties of the 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (phenylalanine sensitive) of Escherichia coli K12

1969 • 37 citations

2,3-dihydroxy-N-benzoylserine: Chemical synthesis and comparison with the natural product

1969 • 36 citations

The biosynthesis of tyrosine in Aerobacter aerogenes: Partial purification of the T protein

1967 • 36 citations

Mutants of Escherichia coli with an Altered Tyrosyl-Transfer Ribonucleic Acid Synthetase

1969 • 35 citations

False feedback inhibition of aromatic amino acid biosynthesis by β-2-thienylalanine

1965 • 34 citations

The effect of 4-methyltryptophan on growth and enzyme systems of Escherichia coli

1956 • 34 citations

Cross Pathway Regulation: Effect of Histidine on the Synthesis and Activity of Enzymes of Aromatic Acid Biosynthesis in Bacillus subtilis

1968 • 34 citations

Ammonium ions as the source of nitrogen for tryptophan biosynthesis in whole cells of Escherichia coli

1967 • 33 citations

Regulation of histidine biosynthetic enzymes in a mutant of Escherichia coli with an altered histidyl-tRNA synthetase

1967 • 33 citations

On the initiation of transcription of the tryptophan operon in Escherichia coli.

1968 • 33 citations

Alteration of Tryptophan-mediated Regulation in Neurospora crassa by Indoleglycerol Phosphate

1968 • 32 citations

A new regulatory gene for the tryptophan operon of Escherichiacoli

1967 • 31 citations

Common Element in the Repression Control of Enzymes of Histidine and Aromatic Amino Acid Biosynthesis in Bacillus subtilus

1968 • 29 citations

ETUDE SYSTEMATIQUE DE MUTANTS INHIBES PAR LEURS PROPRES METABOLITES CHEZ LA LEVURE SACCHAROMYCES CEREVISIAE I. OBTENTION ET CARACTERISATION DES DIFFERENTES CLASSES DE MUTANTS

1967 • 29 citations

Temperature-sensitive Repression of the Tryptophan Operon in Escherichia coli

1969 • 28 citations

PHENYLALANINE-TYROSINE BIOSYNTHESIS IN NEUROSPORA CRASSA

1968 • 28 citations

Purification and Properties of Anthranilate Synthase from Salmonella typhimurium

1969 • 27 citations

Enzymatic Formation of Phenylpyruvic Acid in Pseudomonas Sp. (ATCC 11299a) and Its Regulation

1965 • 27 citations

The nature of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in extracts of wild-type Neurospora crassa: A reaction controlled by two activating substrates and three allosteric negative modifiers

1968 • 25 citations

Tryptophan as an inhibitor of 3-deoxy-arabino-heptulosonate 7-phosphate synthetase

1967 • 24 citations

Chromatography of 3-deoxy-D-arabinoheptulosonic acid-7-phosphate synthetase (trp) on diethylaminoethyl cellulose: a correction

1967 • 24 citations

The Synthesis of p-Aminobenzoic Acid and Folic Acid by Staphylococci Sensitive and Resistant to Sulphonamides

1965 • 23 citations

Regulation of Enzyme Synthesis in the Aromatic Amino Acid Pathway of Bacillus subtilus

1969 • 23 citations

Mutant tyrosine transfer ribonucleic acids

1969 • 20 citations

Regulation of 3-Deoxy- <scp>d</scp> - arabino -Heptulosonic 7-Phosphate Acid Synthetase Activity in Relation to the Synthesis of the Aromatic Vitamins in Escherichia coli K-12

1969 • 20 citations

2,3-Dihydroxybenzoic acid, a new growth factor for multiple aromatic auxotrophs

1967 • 19 citations

Isoenzymes and allosteric inhibition of Neurospora crassa 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase

1970 • 19 citations

Product inhibition of anthranilate synthetase in Salmonella typhimurium

1968 • 19 citations

THE CONVERSION OF SHIKIMIC ACID INTO CERTAIN AROMATIC COMPOUNDS BY CELL-FREE EXTRACTS OF AEROBACTER AEROGENES AND ESCHERICHIA COLI

1963 • 18 citations

A regulatory mutation in tyrosine biosynthesis

1969 • 18 citations

Regulated Enzymes of Aromatic Amino Acid Synthesis: Control, Isozymic Nature, and Aggregation in Bacillus subtilis and Bacillus licheniformis

1969 • 17 citations

Studies concerning the biochemical genetics and physiology of activity and allosteric inhibition mutants of Neurospora crassa 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase

1969 • 16 citations

Prephenate dehydrogenase from Neurospora: Feedback activation by phenylalanine

1969 • 16 citations

In Vivo Regulation of Intermediate Reactions in the Pathway of Tryptophan Biosynthesis in Neurospora crassa

1968 • 16 citations

3-Deoxy-d-arabino-heptulosonic acid 7-phosphate synthetase as an “allosteric” function and ligand interactions with this enzyme from Neurospora crassa

1967 • 15 citations

Transcription of the tryptophan operon of Escherichia coli in vitro I. Detection and quantitative determination of specific RNA

1968 • 14 citations

Aromatic biosynthesis in yeast. II. Feedback inhibition and repression of 3-deoxy-d-arabino-heptulosonic acid 7-phosphate synthase

1968 • 13 citations

Non-coordinate regulation in 5-methyl tryptophan-resistant mutants of Bacillus subtilis

1968 • 11 citations

Control of aromatic amino acid biosynthesis in Salmonella typhimurium

1967 • 10 citations

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