A Serum Factor Enhances Production of Nitric Oxide and Tumor Necrosis Factor-α From Cultured Microglia

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Tumor Necrosis Factor-α

1997 • 864 citations

Soluble CD14 participates in the response of cells to lipopolysaccharide.

1992 • 695 citations

Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum.

1986 • 549 citations

Development of the blood-brain barrier

1990 • 533 citations

Brain glia release factors with opposing actions upon neuronal survival

1993 • 437 citations

Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate

1991 • 421 citations

Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins.

1989 • 411 citations

The Importance of Brain Temperature in Alterations of the Blood-Brain Barrier Following Cerebral Ischemia

1990 • 373 citations

Identification of a Lipid A Binding Site in the Acute Phase Reactant Lipopolysaccharide Binding Protein

1989 • 351 citations

TNF-α Pretreatment Induces Protective Effects against Focal Cerebral Ischemia in Mice

1997 • 346 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

The Microglial Reaction in the Rat Dorsal Hippocampus following Transient Forebrain Ischemia

1991 • 301 citations

Mild Intraischemic Hypothermia Reduces Postischemic Hyperperfusion, Delayed Postischemic Hypoperfusion, Blood-Brain Barrier Disruption, Brain Edema, and Neuronal Damage Volume after Temporary Focal Cerebral Ischemia in Rats

1994 • 245 citations

Tumor Necrosis Factor-Alpha Potentiates Glutamate Neurotoxicity in Human Fetal Brain Cell Cultures

1994 • 243 citations

Plasma lipopolysaccharide (LPS)-binding protein. A key component in macrophage recognition of gram-negative LPS.

1992 • 224 citations

Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia

1996 • 217 citations

Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14.

1996 • 207 citations

Microglia activation after neonatal hypoxic-ischemia

1995 • 206 citations

The possible contribution of microglia and macrophages to delayed neuronal death after ischemia

1993 • 197 citations

Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat.

1992 • 151 citations

Blood‐brain barrier disruption on contrast‐enhanced MRI in patients with mild relapsing‐remitting multiple sclerosis

1995 • 129 citations

Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis

1996 • 117 citations

Low density lipoprotein uptake by macrophages in multiple sclerosis plaques: implications for pathogenesis

1994 • 108 citations

Modulation of Intracellular Formation of Reactive Oxygen Intermediates in Peritoneal Macrophages and Microglia/Brain Macrophages by Propentofylline

1994 • 107 citations

Detection of Superoxide Production by Activated Microglia Using a Sensitive and Specific Chemiluminescence Assay and Microglia‐Mediated PC12h Cell Death

1994 • 107 citations

HIV-1 Associated Dementia: Clinical Features and Pathogenesis

1995 • 94 citations

Hypothermic suppression of microglial activation in culture: inhibition of cell proliferation and production of nitric oxide and superoxide

1997 • 94 citations

Adenosine and Propentofylline Inhibit the Proliferation of Cultured Microglial Cells

1996 • 83 citations

Glia: The not so innocent bystanders

1996 • 64 citations

Role of nitric oxide in disruption of the blood-brain barrier during acute hypertension

1995 • 60 citations

Soluble CD14 promotes LPS activation of CD14-deficient PNH monocytes and endothelial cells.

1995 • 51 citations

Bacterial Components and the Pathophysiology of Injury to the Blood-Brain Barrier: Does Cell Wall Add to the Effects of Endotoxin in Gram-Negative Meningitis?

1992 • 42 citations

Albumin enhances superoxide production in cultured microglia

1997 • 41 citations

Purification and characterization of murine lipopolysaccharide-binding protein

1993 • 40 citations

Platelet-activating factor production by human fetal microglia

1995 • 37 citations

Phagocytosis of NonopsonizedCryptococcus neoformansby Swine Microglia Involves CD14 Receptors

1997 • 33 citations

Activation of microglia in HIV-1 infected brains is not dependent on the presence of HIV-1 antigens

1994 • 28 citations

Involvement of microglia in Alzheimer's disease.

1994 • 26 citations

Serum components enhance bacterial lipopolysaccharide-induced tissue factor expression and tumor necrosis factor-α secretion by bovine alveolar macrophages in vitro

1994 • 26 citations

Intracerebral distribution of albumin after transient cerebral ischemia: light and electron microscopic immunocytochemical investigation

1992 • 25 citations

CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages

1997 • 24 citations

Modulation of glial cell signaling by adenosine and pharmacological reinforcement

1996 • 14 citations

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