HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer

2006 • 5,651 citations

Chemoradiotherapy after Surgery Compared with Surgery Alone for Adenocarcinoma of the Stomach or Gastroesophageal Junction

2001 • 3,402 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial

2007 • 1,508 citations

Chemotherapy in Advanced Gastric Cancer: A Systematic Review and Meta-Analysis Based on Aggregate Data

2006 • 1,146 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

Gastric cancer epidemiology and risk factors

2003 • 760 citations

Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

1999 • 650 citations

Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab

2005 • 644 citations

Mutations of the human E-cadherin (CDH1) gene

1998 • 598 citations

Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.

1996 • 564 citations

The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas

1999 • 477 citations

Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.

2001 • 366 citations

Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer.

1991 • 331 citations

HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer

2006 • 321 citations

Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study

2001 • 298 citations

c-erbB-2 Is of Independent Prognostic Relevance in Gastric Cancer and Is Associated With the Expression of Tumor-Associated Protease Systems

2000 • 284 citations

Her-2/ neu and Breast Cancer

2001 • 217 citations

HER-2/neu expression: A major prognostic factor in endometrial cancer

1992 • 210 citations

Status of c‐erbB‐2 in gastric adenocarcinoma: A comparative study of immunohistochemistry, fluorescence in situ hybridization and enzyme‐linked immuno‐sorbent assay

2002 • 196 citations

Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus

2006 • 189 citations

Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models

2006 • 189 citations

Clinical Significance of the Epidermal Growth Factor Receptor and HER2 Receptor in Resectable Gastric Cancer

2003 • 177 citations

Expression of ERBB2 in human gastric carcinomas: relationship between p185ERBB2 expression and the gene amplification.

1990 • 162 citations

Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer

1991 • 159 citations

Expression of Epidermal Growth Factor Receptors on Normal Human Gastric Epithelia and Gastric Carcinomas

1986 • 156 citations

Clinical significance of epidermal growth factor (EGF), EGF receptor, and c-erbb-2 in human gastric cancer

1995 • 155 citations

Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection

1997 • 144 citations

A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines.

1993 • 133 citations

Overexpression of c‐ erb B‐2 protein in gastric cancer. Its correlation with long‐term survival of patients

1993 • 132 citations

Relationship of C-erbB-2 protein expression and gene amplification to invasion and metastasis in human gastric cancer

1993 • 129 citations

HER 2/neu protein expression in colorectal cancer

2006 • 129 citations

ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix.

1994 • 124 citations

Chemotherapy for gastric cancer

2006 • 117 citations

Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with long-term survival of patients

1993 • 116 citations

Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model.

2005 • 114 citations

Clinicopathological significance of c‐erbB‐2 protein expression in human gastric carcinoma

1992 • 101 citations

The use of molecular biology in diagnosis and prognosis of gastric cancer

2000 • 94 citations

HER-2/neu Oncogene Characterization in Head and Neck Squamous Cell Carcinoma

1995 • 93 citations

Prognostic value of Lauren classification and C-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastro-esophageal junction

1998 • 92 citations

Double immunostaining for c-erbB-2 and p53 in human stomach cancer cells

1993 • 90 citations

Serum levels of HER-2neu (C-erbB-2) correlate with overexpression of p185neu in human ovarian cancer

1993 • 84 citations

Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches

2004 • 75 citations

Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer

2008 • 73 citations

Breast Cancer in the 21st Century: Neu Opportunities and Neu Challenges

2001 • 69 citations

Analysis of 154 actual five-year survivors of gastric cancer

2000 • 63 citations

Protein Overexpression and Gene Amplification of c-erbB-2 in Pulmonary Carcinomas: A Comparative Immunohistochemical and Fluorescence In Situ Hybridization Study

2001 • 61 citations

Cox-2 and Her2/neu co-expression in invasive bladder cancer

2005 • 60 citations

E-cadherin and hereditary diffuse gastric cancer

2007 • 59 citations

Phase II of trastuzumab and cisplatin in patients (pts) with advanced gastric cancer (AGC) with HER2/neu overexpression/amplification

2007 • 56 citations

Occurrence of microsatellite instability in gastric carcinoma is associated with enhanced expression of erbB-2 oncoprotein.

1995 • 55 citations

Significance of erb B‐2 Gene Product as a Target Molecule for Cancer Therapy

1994 • 36 citations

Correlation between HER2/neu overexpression/amplification and clinicopathologic parameters in advanced gastric cancer (AGC) patients (pts): A prospective study

2006 • 36 citations

HER2-positive advanced gastric cancer: similar HER2-positivity levels to breast cancer

2007 • 34 citations

Expression of HER2 in gastric cancer: Comparison between protein expression and gene amplification using a new commercial kit

2004 • 26 citations

Combination of arabinosyl cytosine, methylglyoxal bis (guanylhydrazone), 6-mercaptopurine and prednisone in the treatment of acute myelocytic leukemia

1969 • 20 citations

Expression of HER2 in gastric cancer: Comparison between protein expression and gene amplification using a new commercial kit

2004 • 14 citations