Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

A Flexible System of Enzymatic Analysis

1972 • 4,133 citations

Upstream and downstream of mTOR

2004 • 4,085 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 • 2,039 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2004 • 1,631 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Ink4a/Arf expression is a biomarker of aging

2004 • 1,382 citations

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 • 1,101 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 • 909 citations

Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

2004 • 773 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

2006 • 650 citations

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

1998 • 636 citations

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

2005 • 614 citations

mTOR, translation initiation and cancer

2006 • 592 citations

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

2000 • 569 citations

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

2001 • 540 citations

Amino Acid and Insulin Signaling via the mTOR/p70 S6 Kinase Pathway

2001 • 529 citations

Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

2001 • 509 citations

Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

2001 • 381 citations

Regulation of the p70 S6 Kinase by Phosphorylation in Vivo

1998 • 375 citations

Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

2001 • 328 citations

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

2007 • 316 citations

TOR Signaling

2003 • 222 citations

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells

2004 • 213 citations

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

2005 • 212 citations

Amino acid metabolism, insulin secretion and diabetes

2007 • 202 citations

Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

2008 • 192 citations

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells

2004 • 182 citations

Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

2008 • 170 citations

Insulin Receptor Substrate-2 Proteasomal Degradation Mediated by a Mammalian Target of Rapamycin (mTOR)-induced Negative Feedback Down-regulates Protein Kinase B-mediated Signaling Pathway in β-Cells

2004 • 143 citations

Translation Factor eIF4E Rescues Cells from Myc-dependent Apoptosis by Inhibiting Cytochromec Release

2003 • 114 citations

Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1

2000 • 103 citations

B-cell size influences glucose-stimulated insulin secretion

1993 • 66 citations

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation

2008 • 64 citations

Glycogen Synthase Kinase - 3 Phosphorylates and Regulates the Stability of p27kip1 Protein

2007 • 33 citations

Intermittent protein–calorie malnutrition in the young rat causes long-term impairment of the insulin secretory response to glucose in vitro

1988 • 30 citations