Rapid induction of cytokine and E-selectin expression in the liver in response to metastatic tumor cells.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Multistep Nature of Metastatic Inefficiency

1998 • 1,186 citations

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

1984 • 820 citations

The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide

1992 • 698 citations

Biological behavior of malignant melanoma cells correlated to their survival in vivo.

1975 • 586 citations

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.

1996 • 513 citations

Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study.

1993 • 417 citations

Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte

1990 • 391 citations

Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha.

1992 • 383 citations

The Cellular Basis of Site-Specific Tumor Metastasis

1990 • 349 citations

Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A

1991 • 347 citations

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression

1985 • 266 citations

Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis

1997 • 216 citations

Redirection of tumor metastasis by expression of E-selectin in vivo.

1996 • 169 citations

Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.

1990 • 160 citations

Interactions between cancer cells and the microvasculature: a rate-regulator for metastasis

1989 • 144 citations

E‐selectin‐mediated dynamic interactions of breast‐and colon‐cancer cells with endothelial‐cell monolayers

1995 • 132 citations

The role of the I_sK protein in the specific pharmacological properties of the I_Ks channel complex

1997 • 128 citations

Control by IFN-gamma and PGE2 of TNF alpha and IL-1 production by human monocytes.

1989 • 123 citations

Tumor Cell Nitric Oxide Inhibits Cell Growthin Vitro,but Stimulates Tumorigenesis and Experimental Lung Metastasisin Vivo

1996 • 105 citations

Regulation of P-selectin expression in human endothelial cells by nitric oxide

1997 • 99 citations

Characterization of two highly metastatic variants of Lewis lung carcinoma with different organ specificities.

1986 • 98 citations

Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1alpha on metastasis and the location of B16F1 melanoma cell arrest.

1997 • 97 citations

Endothelial leukocyte adhesion molecule-1-dependent adhesion of colon carcinoma cells to vascular endothelium is inhibited by an antibody to Lewis fucosylated type I carbohydrate chain.

1992 • 91 citations

Relationship between blood plasma prostaglandin E2 and liver and lung metastases in colorectal cancer

1990 • 67 citations

Sialyl Lewis(x) antigen as defined by monoclonal antibody AM-3 is a marker of dysplasia in the colonic adenoma-carcinoma sequence.

1992 • 67 citations

Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells

1996 • 66 citations

Paracrine growth stimulation by hepatocyte-derived insulin-like growth factor-1: a regulatory mechanism for carcinoma cells metastatic to the liver.

1994 • 64 citations

Nitric Oxide Regulates Interleukin 1 Bioactivity Released from Murine Macrophages

1996 • 58 citations

E‐selectin expression induced by pancreas‐carcinoma‐derived interleukin‐1α results in enhanced adhesion of pancreas‐carcinoma cells to endothelial cells

1995 • 54 citations

Enhancement of metastatic potential by gamma-interferon.

1991 • 53 citations

Regulation of tumor necrosis factor-α-mRNA synthesis and distribution of tumor necrosis factor-α-mRNA synthesizing cells in rat liver during experimental endotoxemia

1994 • 47 citations

Differences in the repertoires of basement membrane degrading enzymes in two carcinoma sublines with distinct patterns of site-selective metastasis

1992 • 36 citations

A high level of prostaglandin E2 (PGE2) in the portal vein suppresses liver-associated immunity and promotes liver metastases

1995 • 35 citations

Effects of systemic complement activation and neutrophil-mediated pulmonary injury on the retention and metastasis of circulating cancer cells in mouse lungs.

1990 • 31 citations

Novel Endothelial Cell Activation Factor(s) Released from Activated Platelets Which Induce E-Selectin Expression and Tumor Cell Adhesion to Endothelial Cells: A Preliminary Note

1994 • 27 citations

Chemotactic activity of endothelial cell-derived interleukin 1 for human tumor cells.

1988 • 27 citations

The Importance of L-arginine Metabolism in Melanoma: An Hypothesis for the Role of Nitric Oxide and Polyamines in Tumor Angiogenesis

1997 • 26 citations

Interleukin 1?-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma

1998 • 25 citations

Human monocytes induce a carcinoma cell line to secrete high amounts of nitric oxide.

1996 • 23 citations

The role of E-selectin for neutrophil activation and tumor metastasis in vivo.

1997 • 20 citations

Direct Correlation between Cell Membrane Fluctuations, Cell Filterability and the Metastatic Potential of Lymphoid Cell Lines

1994 • 19 citations

NO‐dependent and NO‐independent IL‐1 production by a human colonic epithelial cell line under inflammatory stress

1997 • 16 citations

Effects of interferon-? on cell differentiation and cytokine production of a human monoblast cell line, U937

1995 • 13 citations

Kupffer cell/tumor cell interactions and hepatic metastasis in colorectal cancer

1994 • 12 citations

Induction of ICAM-1 HLA-DR Molecules by IFN-Gamma and Oncogene Expression in Human Bladder Cancer Cell Lines

1997 • 9 citations

Endothelial Cell Adhesion Molecules and Their Role in Organ Preference of Metastasis.

1992 • 8 citations

Interferon γ stimulates prostaglandin E2 production by mouse Kupffer cells

1990 • 4 citations