Population genetic structure of variable drug response

Inference of Population Structure Using Multilocus Genotype Data

2000 • 32,000 citations

AN EXACT TEST FOR POPULATION DIFFERENTIATION

1995 • 2,846 citations

Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics

1999 • 2,458 citations

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

1999 • 722 citations

Genetic evidence for a higher female migration rate in humans

1998 • 613 citations

MOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM

1997 • 540 citations

Nomenclature for human CYP2D6 alleles

1996 • 406 citations

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

1991 • 355 citations

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

1990 • 304 citations

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

1990 • 263 citations

Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms

1999 • 245 citations

A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.

1998 • 203 citations

Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data

1999 • 179 citations

A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia

2000 • 169 citations

[23] Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism

1996 • 115 citations

NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations

1998 • 103 citations

Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine

1999 • 82 citations

Consistent Long-Range Linkage Disequilibrium Generated by Admixture in a Bantu-Semitic Hybrid Population

2000 • 81 citations

Ethnic Factors in the Acceptability of Foreign Clinical Data

1998 • 74 citations

11. Gene–nutrient interactions in nutritional epidemiology

1997 • 8 citations