Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis-induced inflammation and virulence

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

2001 • 3,631 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

THE ENVELOPE OF MYCOBACTERIA

1995 • 1,868 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

Mycobacterium tuberculosisPathogenesis and Molecular Determinants of Virulence

2003 • 1,065 citations

A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response

2004 • 734 citations

Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

1999 • 730 citations

A Novel Mycolic Acid Cyclopropane Synthetase Is Required for Cording, Persistence, and Virulence of Mycobacterium tuberculosis

2000 • 634 citations

Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature‐tagged transposon mutagenesis

1999 • 613 citations

Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin

1999 • 612 citations

Mycolic acids: structure, biosynthesis and physiological functions

1998 • 551 citations

Persistent bacterial infections: the interface of the pathogen and the host immune system

2004 • 545 citations

Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection

2003 • 402 citations

Membrane cyclopropane fatty acid content is a major factor in acid resistance of Escherichia coli

1999 • 399 citations

The Secret Lives of the Pathogenic Mycobacteria

2003 • 394 citations

Analysis of the Phthiocerol Dimycocerosate Locus ofMycobacterium tuberculosis

2001 • 367 citations

Microbial Pathogenesis of Mycobacterium tuberculosis: Dawn of a Discipline

2001 • 338 citations

Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice

2000 • 307 citations

Mycobacterium tuberculosis CDC1551 Induces a More Vigorous Host Response In Vivo and In Vitro, But Is Not More Virulent Than Other Clinical Isolates

1999 • 300 citations

Deletion of Two-Component Regulatory Systems Increases the Virulence of Mycobacterium tuberculosis

2003 • 266 citations

The Methyl-Branched Fortifications of Mycobacterium tuberculosis

2002 • 257 citations

Unique Transcriptome Signature of Mycobacterium tuberculosis in Pulmonary Tuberculosis

2006 • 238 citations

Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth

2002 • 238 citations

Mycobacterium tuberculosiscontrols host innate immune activation through cyclopropane modification of a glycolipid effector molecule

2005 • 228 citations

Cord factor trehalose 6,6′-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages

2003 • 221 citations

Hypervirulent mutant ofMycobacterium tuberculosisresulting from disruption of themce1operon

2003 • 211 citations

Mycobacterium tuberculosisInhibits Macrophage Responses to IFN-γ through Myeloid Differentiation Factor 88-Dependent and -Independent Mechanisms

2004 • 202 citations

Immunopathologic Effects of Tumor Necrosis Factor Alpha in Murine Mycobacterial Infection Are Dose Dependent

2000 • 200 citations

Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

2003 • 191 citations

The immunological aspects of latency in tuberculosis

2003 • 183 citations

In Vivo Activity of Released Cell Wall Lipids ofMycobacterium bovisBacillus Calmette-Guérin Is Due Principally to Trehalose Mycolates

2005 • 181 citations

Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy

2003 • 179 citations

Phospholipid modifications in bacteria

2002 • 154 citations

What's good for the host is good for the bug

2005 • 147 citations

Carbocyclic fatty acids in plants: Biochemical and molecular genetic characterization of cyclopropane fatty acid synthesis of Sterculia foetida

2002 • 140 citations

The Mycobacterium tuberculosis cmaA2 Gene Encodes a Mycolic Acid trans-Cyclopropane Synthetase

2001 • 135 citations

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set

2004 • 131 citations

Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence b bThe precise locations of all of the insertions examined in this study can be found as supplementary data in Microbiology Online (http://mic.sgmjournals.org).

2002 • 127 citations

A polymerase chain reaction based method for detecting Mycoplasma/Acholeplasma contaminants in cell culture

2000 • 126 citations

Influence of trehalose 6,6′-dimycolate (TDM) during mycobacterial infection of bone marrow macrophages

2002 • 120 citations

Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis

2005 • 113 citations

Trehalose 6,6′-Dimycolate (Cord Factor) ofMycobacterium tuberculosisInduces Foreign-Body- and Hypersensitivity-Type Granulomas in Mice

2001 • 105 citations

The Envelope of Mycobacteria

1995 • 104 citations

Lethal Granuloma Disintegration in Mycobacteria-Infected TNFRp55−/− Mice Is Dependent on T Cells and IL-12

2000 • 99 citations

Mycobacterial Antigens Exacerbate Disease Manifestations inMycobacterium tuberculosis-Infected Mice

2002 • 95 citations

MMAS-1, the Branch Point Between cis- and trans-Cyclopropane-containing Oxygenated Mycolates in Mycobacterium tuberculosis

1997 • 90 citations

The Mycobacterium tuberculosis SigD sigma factor controls the expression of ribosome-associated gene products in stationary phase and is required for full virulence

2004 • 86 citations

The mmaA2 Gene of Mycobacterium tuberculosis Encodes the Distal Cyclopropane Synthase of the α-Mycolic Acid

2003 • 83 citations

Cyclopropene fatty acids of selected seed oils from bombacaceae, malvaceae, and sterculiaceae

1978 • 75 citations

Deletionof Mycobacterium tuberculosis Sigma Factor E Results inDelayed Time to Death with Bacterial Persistence in the Lungsof Aerosol-InfectedMice

2003 • 75 citations

Mycobacteriumbovis BCG genes involved in the biosynthesis of cyclopropyl keto‐ and hydroxy‐mycolic acids

1997 • 69 citations

The Biosynthesis of Mycolic Acids in Mycobacterium tuberculosis

1998 • 65 citations

Induction of pulmonary granulomas, macrophage procoagulant activity, and tumor necrosis factor-alpha by trehalose glycolipids.

1993 • 63 citations

Molecular Genetics ofMycobacterium tuberculosisPathogenesis

2003 • 61 citations

T cell-derived tumour necrosis factor is essential, but not sufficient, for protection againstMycobacterium tuberculosisinfection

2004 • 55 citations

Glycolipids of Recent Clinical Isolates of Mycobacterium tuberculosis: Chemical Characterization and Immunoreactivity

1989 • 54 citations

Characterization of Cyclopropane Fatty-acid Synthase fromSterculia foetida

2003 • 54 citations

Extravascular coagulation and fibrinolysis in murine lung inflammation induced by the mycobacterial cord factor trehalose-6,6'-dimycolate.

1994 • 48 citations

Development of a trehalose 6,6'-dimycolate model which explains cord formation by Mycobacterium tuberculosis

1993 • 47 citations

A toxic lipid component of the tubercle bacillus (cord factor). I. Isolation from petroleum ether extracts of young bacterial cultures.

1953 • 38 citations

Failure of CD1D^-/-Mice to Elicit Hypersensitive Granulomas to Mycobacterial Cord Factor Trehalose 6,6′-Dimycolate

2004 • 35 citations

Requisite Role for Complement C5 and the C5a Receptor in Granulomatous Response to Mycobacterial Glycolipid Trehalose 6,6′‐Dimycolate

2005 • 31 citations

Mycobacterial Glycolipid Cord Factor Trehalose 6,6’-Dimycolate Causes a Decrease in Serum Cortisol during the Granulomatous Response

2002 • 19 citations

A toxic lipid component of the tubercle bacillus (cord factor). II. Occurrence in chloroform extracts of young and older bacterial cultures.

1953 • 13 citations

A toxic lipid component of the tubercle bacillus (cord factor). III. Occurrence and distribution in various bacterial extracts.

1953 • 12 citations