The Secret Lives of the Pathogenic Mycobacteria

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

1998 • 7,572 citations

Global Burden of Tuberculosis

1999 • 3,009 citations

Immunology of Tuberculosis

2001 • 2,111 citations

Massive gene decay in the leprosy bacillus

2001 • 1,761 citations

A new evolutionary scenario for the Mycobacterium tuberculosis complex

2002 • 1,564 citations

Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray

1999 • 1,537 citations

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

2000 • 1,429 citations

Common themes in microbial pathogenicity revisited

1997 • 1,370 citations

Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling

2002 • 1,362 citations

Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

2000 • 1,300 citations

Identification of nitric oxide synthase as a protective locus against tuberculosis

1997 • 1,161 citations

The Epidemiology of Tuberculosis in San Francisco -- A Population-Based Study Using Conventional and Molecular Methods

1994 • 1,141 citations

Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis

1996 • 1,088 citations

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

2002 • 1,037 citations

Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination

1997 • 1,028 citations

Nonreplicating Persistence ofMycobacteriumTuberculosis

2001 • 785 citations

Regulation of theMycobacterium tuberculosishypoxic response gene encoding α-crystallin

2001 • 720 citations

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti

2002 • 697 citations

Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

2003 • 694 citations

Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages

2002 • 682 citations

The Mycobacterium avium complex

1993 • 681 citations

Whole-Genome Comparison ofMycobacterium tuberculosisClinical and Laboratory Strains

2002 • 678 citations

A Novel Mycolic Acid Cyclopropane Synthetase Is Required for Cording, Persistence, and Virulence of Mycobacterium tuberculosis

2000 • 634 citations

Mycolactone: A Polyketide Toxin from Mycobacterium ulcerans Required for Virulence

1999 • 628 citations

DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells

2002 • 620 citations

Exogenous Reinfection as a Cause of Recurrent Tuberculosis after Curative Treatment

1999 • 616 citations

Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature‐tagged transposon mutagenesis

1999 • 613 citations

Comprehensive identification of conditionally essential genes in mycobacteria

2001 • 610 citations

Essential Role for Cholesterol in Entry of Mycobacteria into Macrophages

2000 • 610 citations

A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria

1999 • 573 citations

A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains

2000 • 566 citations

Deletion of RD1 fromMycobacterium tuberculosisMimics Bacille Calmette‐Guérin Attenuation

2002 • 561 citations

The granulomatous inflammatory response. A review.

1976 • 549 citations

Real-Time Visualization of Mycobacterium-Macrophage Interactions Leading to Initiation of Granuloma Formation in Zebrafish Embryos

2002 • 529 citations

Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival.

1975 • 528 citations

Factors Influencing Numbers of Mycobacterium avium , Mycobacterium intracellulare , and Other Mycobacteria in Drinking Water Distribution Systems

2001 • 508 citations

BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life.

1977 • 505 citations

Tuberculosis: Latency and Reactivation

2001 • 495 citations

Mechanisms of latency in Mycobacterium tuberculosis

1998 • 476 citations

Macrophage Receptors forMycobacterium tuberculosis

1998 • 473 citations

Interaction of Mycobacterium avium with environmental amoebae enhances virulence

1997 • 442 citations

HIV-1 and recurrence, relapse, and reinfection of tuberculosis after cure: a cohort study in South African mineworkers

2001 • 442 citations

The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination

2001 • 442 citations

Cryptococcus neoformansIs a Facultative Intracellular Pathogen in Murine Pulmonary Infection

2000 • 423 citations

Mannosylated Lipoarabinomannans Inhibit IL-12 Production by Human Dendritic Cells: Evidence for a Negative Signal Delivered Through the Mannose Receptor

2001 • 415 citations

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis

1995 • 411 citations

Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection

2000 • 408 citations

Cytokine Activation Leads to Acidification and Increases Maturation of Mycobacterium avium-Containing Phagosomes in Murine Macrophages

1998 • 393 citations

An essential role for phoP in Mycobacterium tuberculosis virulence

2001 • 378 citations

Trafficking and Release of Mycobacterial Lipids from Infected Macrophages

2000 • 352 citations

Effects of cytokines on mycobacterial phagosome maturation

1998 • 349 citations

Microbial Pathogenesis of Mycobacterium tuberculosis: Dawn of a Discipline

2001 • 338 citations

Depletion of Cd4+ T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2

2000 • 335 citations

Aquatic Insects as a Vector for Mycobacterium ulcerans

2002 • 328 citations

Genetic control of resistance to experimental infection with virulentMycobacterium tuberculosis

2000 • 314 citations

MICROBIAL PERSISTENCE

1966 • 306 citations

Latent Mycobacterium tuberculosis–persistence, patience and winning by waiting

2000 • 277 citations

Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis

1997 • 274 citations

Are the PE‐PGRS proteins of Mycobacterium tuberculosis variable surface antigens?

2002 • 268 citations

Neutrophils Play a Protective Nonphagocytic Role in SystemicMycobacterium tuberculosisInfection of Mice

2000 • 268 citations

Comparing Genomes within the Species Mycobacterium tuberculosis

2001 • 260 citations

Expression of Th1-mediated immunity in mouse lungs induces aMycobacterium tuberculosistranscription pattern characteristic of nonreplicating persistence

2002 • 256 citations

Basic Mechanisms of Chemotherapy

1979 • 252 citations

Mycobacterium bovisBCG Response Regulator Essential for Hypoxic Dormancy

2002 • 244 citations

AMycobacterium ulceransToxin, Mycolactone, Causes Apoptosis in Guinea Pig Ulcers and Tissue Culture Cells

2000 • 243 citations

Genomic Deletions Suggest a Phylogeny for theMycobacterium tuberculosisComplex

2002 • 243 citations

Reactivation of Latent Tuberculosis: Variations on the Cornell Murine Model

1999 • 242 citations

Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth

2002 • 238 citations

outer membrane remodeling: role in resistance to host innate immunity

2001 • 232 citations

Isoniazid prophylaxis among Alaskan Eskimos: a final report of the bethel isoniazid studies.

1979 • 232 citations

Legionella pneumophila Replication Vacuoles Mature into Acidic, Endocytic Organelles

2000 • 232 citations

Molecular Evidence of Endogenous Reactivation ofMycobacterium tuberculosisafter 33 Years of Latent Infection

2002 • 231 citations

Reduced immunopathology and mortality despite tissue persistence in aMycobacterium tuberculosismutant lacking alternative σ factor, SigH

2002 • 230 citations

Effects of Aminoguanidine on Latent Murine Tuberculosis

1998 • 225 citations

Role of the Cell Wall Phenolic Glycolipid-1 in the Peripheral Nerve Predilection of Mycobacterium leprae

2000 • 224 citations

Mycobacterium tuberculosissignal transduction system required for persistent infections

2001 • 223 citations

The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease

1996 • 218 citations

Comparing Genomes within the Species Mycobacterium tuberculosis

2001 • 217 citations

Depletion of Alveolar Macrophages Exerts Protective Effects in Pulmonary Tuberculosis in Mice

2001 • 210 citations

Fate ofMycobacterium tuberculosiswithin Murine Dendritic Cells

2001 • 208 citations

Attenuation of Virulence by Disruption of the Mycobacterium tuberculosis erp Gene

1998 • 203 citations

Nonopsonic Phagocytosis of Mycobacterium kansasii by Human Neutrophils Depends on Cholesterol and Is Mediated by CR3 Associated with Glycosylphosphatidylinositol-Anchored Proteins

2000 • 203 citations

Pathogenesis of Pulmonary Tuberculosis: an Interplay of Tissue-Damaging and Macrophage-Activating Immune Responses-Dual Mechanisms That Control Bacillary Multiplication

2014 • 201 citations

Contact-Dependent Demyelination by Mycobacterium leprae in the Absence of Immune Cells

2002 • 187 citations

Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis

2000 • 183 citations

Ultrastructural Study of the Behavior of Macrophages Toward Parasitic Mycobacteria

1972 • 181 citations

Detection of mRNA Transcripts and Active Transcription in Persistent Mycobacterium tuberculosis Induced by Exposure to Rifampin or Pyrazinamide

2000 • 177 citations

Characterization of the major membrane protein of virulent Mycobacterium tuberculosis

1992 • 176 citations

Exogenous Reinfection with Tuberculosis on a European Island with a Moderate Incidence of Disease

2001 • 172 citations

Drosophila melanogaster Is a Genetically Tractable Model Host for Mycobacterium marinum

2003 • 169 citations

Differentiation of Mycobacterium ulcerans , M. marinum , and M. haemophilum : Mapping of Their Relationships to M. tuberculosis by Fatty Acid Profile Analysis, DNA-DNA Hybridization, and 16S rRNA Gene Sequence Analysis

1998 • 169 citations

In Situ Detection of Mycobacterium tuberculosis Transcripts in Human Lung Granulomas Reveals Differential Gene Expression in Necrotic Lesions

2002 • 164 citations

The Efficiency of the Translocation ofMycobacterium tuberculosisacross a Bilayer of Epithelial and Endothelial Cells as a Model of the Alveolar Wall Is a Consequence of Transport within Mononuclear Phagocytes and Invasion of Alveolar Epithelial Cells

2002 • 163 citations

Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages

1997 • 161 citations

Mycobacterium and the coat of many lipids

2002 • 161 citations

Immunopathogenesis of Pulmonary Tuberculosis

1993 • 161 citations

Pyrazinamide Sterilizing ActivityIn Vitroagainst SemidormantMycobacterium tuberculosisBacterial Populations

1992 • 159 citations

Comparative Genetic Analysis of Mycobacterium ulcerans and Mycobacterium marinum Reveals Evidence of Recent Divergence

2000 • 157 citations

Analysis of Nitric Oxide Synthase and Nitrotyrosine Expression in Human Pulmonary Tuberculosis

2002 • 157 citations

Identification of Mycobacterial Surface Proteins Released into Subcellular Compartments of Infected Macrophages

2000 • 155 citations

Characterization of Murine Lung Dendritic Cells Infected withMycobacterium tuberculosis

2001 • 153 citations

Mycobacterium tuberculosis Genes Induced during Infection of Human Macrophages

2002 • 144 citations

Guinea Pig Model of Tuberculosis

2014 • 144 citations

Negligible Genetic Diversity ofMycobacterium tuberculosisHost Immune System Protein Targets: Evidence of Limited Selective Pressure

2000 • 142 citations

The M Cell as a Portal of Entry to the Lung for the Bacterial Pathogen Mycobacterium tuberculosis

1999 • 139 citations

Survival ofMycobacterium aviumandMycobacterium tuberculosisin Acidified Vacuoles of Murine Macrophages

1999 • 135 citations

Rapid Neutrophil Response Controls Fast‐Replicating Intracellular Bacteria but Not Slow‐ReplicatingMycobacterium tuberculosis

2000 • 130 citations

Basic Mechanisms of Chemotherapy

1979 • 125 citations

Intracellular Replication of Mycobacterium marinum within Dictyostelium discoideum : Efficient Replication in the Absence of Host Coronin

2003 • 124 citations

Tuberculosis

1994 • 123 citations

Experimental models to explain the high sterilizing activity of rifampin in the chemotherapy of tuberculosis.

1981 • 123 citations

Mycobacterial surface moieties are released from infected macrophages by a constitutive exocytic event

2001 • 123 citations

Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.

1995 • 122 citations

Goldfish, Carassius auratus , a Novel Animal Model for the Study of Mycobacterium marinum Pathogenesis

1998 • 116 citations

Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens)

1997 • 113 citations

Hijacking the host: survival of pathogenic mycobacteria inside macrophages

2002 • 108 citations

Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection

2002 • 108 citations

Mouse Model of Tuberculosis

2014 • 107 citations

Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis

1999 • 106 citations

Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis

2003 • 103 citations

Analysis of the host-parasite equilibrium in chronic murine tuberculosis by total and viable bacillary counts.

1961 • 102 citations

Dynamic Nature of Host-Pathogen Interactions inMycobacterium marinumGranulomas

2001 • 99 citations

GROWTH CHARACTERISTICS OF TUBERCLE BACILLI AND CERTAIN OTHER MYCOBACTERIA IN H<scp>E</scp>L<scp>A</scp> CELLS

1957 • 99 citations

The histopathologic spectrum in Mycobacterium marinum infection.

1985 • 95 citations

Identification of Salmonella typhi genes expressed within macrophages by selective capture of transcribed sequences (SCOTS)

2001 • 94 citations

ChronicListeriaInfection in SCID Mice: Requirements for the Carrier State and the Dual Role of T Cells in Transferring Protection or Suppression

1998 • 93 citations

Immunological and pathological comparative analysis between experimental latent tuberculous infection and progressive pulmonary tuberculosis

2002 • 92 citations

Transposon Mutagenesis ofMycobacterium marinumIdentifies a Locus Linking Pigmentation and Intracellular Survival

2003 • 89 citations

A Mouse Model of the Recrudescence of Latent Tuberculosis in the Elderly

1988 • 88 citations

TUBERCULOUS INFECTION IN THE LIGHT OF TUBERCULIN MATRICULATION12

1952 • 88 citations

TRANSMISSION AND PATHOGENESIS OF TUBERCULOSIS

1980 • 86 citations

Mycobacterium aviumGenes Expressed during Growth in Human Macrophages Detected by Selective Capture of Transcribed Sequences (SCOTS)

2002 • 85 citations

Mycobacterium africanum Subtype II Is Associated with Two Distinct Genotypes and Is a Major Cause of Human Tuberculosis in Kampala, Uganda

2002 • 84 citations

Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance

2001 • 83 citations

Tubercle Bacilli in Latent Tuberculous Lesions in Lung Tissue without Tuberculous Lesions

1928 • 82 citations

In vivo veritas: The search for TB drug targets goes live

2000 • 82 citations

Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomes

2002 • 81 citations

Nitric oxide signaling and NO dependent transcriptional control in bacterial denitrification by members of the FNR-CRP regulator family.

2002 • 79 citations

PROTAGONIST: Mycobacterium avium subspecies paratuberculosis is a cause of Crohn's disease

2001 • 78 citations

Use of fluorescence induction and sucrose counterselection to identify Mycobacterium tuberculosis genes expressed within host cells

1999 • 75 citations

A Nonhuman Primate Model for Preclinical Testing of New Tuberculosis Vaccines

2000 • 72 citations

When Did Mycobacterium tuberculosis Infection First Occur in The New World?: An Important Question with Public Health Implications

1995 • 68 citations

Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure

2002 • 67 citations

Immunogenicity ofMycobacterium tuberculosisRD1 region gene products in infected cattle

2002 • 65 citations

NOS2‐derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium‐infected mice without affecting bacterial loads

1999 • 63 citations

Identification of viable and non-viable Mycobacterium tuberculosis in mouse organs by directed RT-PCR for antigen 85B mRNA

2000 • 60 citations

Change in colony morphology influences the virulence as well as the biochemical properties of the complex

1998 • 55 citations

Characterization of an Unusual Mycobacterium: a Possible Missing Link between Mycobacterium marinum and Mycobacterium ulcerans

2002 • 52 citations

Rabbit Model of Tuberculosis

2014 • 51 citations

Mycobacterial Protein HbhA Binds Human Complement Component C3

2001 • 50 citations

Mycobacterium ulceransCytotoxicity in an Adipose Cell Model

2001 • 50 citations

The residual infectivity of the primary complex of tuberculosis.

1938 • 49 citations

Endothelial cells and the pathogenesis of lepromatous neuritis:insights from the armadillo model

2000 • 48 citations

Cellular signaling with nitric oxide and cyclic guanosine monophosphate

2000 • 44 citations

A New Model for Studying the Effects ofMycobacterium lepraeon Schwann Cell and Neuron Interactions

2002 • 43 citations

Tumor Necrosis Factor (TNF) and a TNF-Mimetic Peptide Modulate the Granulomatous Response toMycobacterium bovisBCG Infection In Vivo

1999 • 42 citations

A Mouse Model for Latent Tuberculosis

1998 • 39 citations

Phenotypic consequences of red–white colony type variation in Mycobacterium avium

2001 • 31 citations

The viability and virulence of old cultures of tubercle bacilli

1951 • 27 citations

Life on the inside: Probing Mycobacterium tuberculosis gene expression during infection

2000 • 25 citations

Effect of Mycobacterial Infection on Virus Loads and Disease Progression in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

2000 • 25 citations

Localisation of mycobacterial DNA and mRNA in human tuberculous granulomas

2002 • 25 citations

Suspension cultivation of Mycobacterium ulcerans for the production of mycolactones

2001 • 24 citations

The occurrence of virulent tubercle bacilli in presumably non-tuberculous lung tissue.

1939 • 19 citations

Ultrastructure of the Interaction between Mycobacterium tuberculosis- H37Rv-Containing Phagosomes and the Lysosomal Compartment in Human Alveolar Macrophages

2002 • 13 citations

Molecular approaches to tuberculosis

2001 • 10 citations

Pathogen strategies

1999 • 3 citations

Suspension cultivation of Mycobacterium ulcerans for the production of mycolactones

2001 • 2 citations