Dissociation of the Tubulin Dimer Is Extremely Slow, Thermodynamically Very Unfavorable, and Reversible in the Absence of an Energy Source

Structure of the αβ tubulin dimer by electron crystallography

1998 • 2,006 citations

High-Resolution Model of the Microtubule

1999 • 1,138 citations

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

1988 • 985 citations

[39] Preparation of modified tubulins

1991 • 724 citations

XLVI.On the determination of the velocity constant of a unimolecular reaction

1926 • 623 citations

Kinetics of protein-protein association explained by Brownian dynamics computer simulation.

1992 • 578 citations

Resistance to antimitotic drugs in Chinese hamster ovary cells correlates with changes in the level of polymerized tubulin

1991 • 225 citations

Adp Ribosylation Factor-like Protein 2 (Arl2) Regulates the Interaction of Tubulin-Folding Cofactor D with Native Tubulin

2000 • 217 citations

Polymerization of FtsZ, a Bacterial Homolog of Tubulin

2001 • 203 citations

Tubulin Subunits Exist in an Activated Conformational State Generated and Maintained by Protein Cofactors

1997 • 193 citations

Dominant effects of tubulin overexpression in Saccharomyces cerevisiae.

1989 • 191 citations

Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes.

1990 • 182 citations

Reversible dissociation of the αβ dimer of tubulin from bovine brain

1978 • 162 citations

Two cofactors and cytoplasmic chaperonin are required for the folding of alpha- and beta-tubulin.

1993 • 161 citations

The free energy for hydrolysis of a microtubule-bound nucleotide triphosphate is near zero: all of the free energy for hydrolysis is stored in the microtubule lattice [published erratum appears in J Cell Biol 1995 Apr;129(2):549]

1994 • 160 citations

Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function.

1990 • 157 citations

Evidence that a single monolayer tubulin-GTP cap is both necessary and sufficient to stabilize microtubules.

1996 • 148 citations

Mg2+ dependence of guanine nucleotide binding to tubulin.

1987 • 140 citations

Turnover of tubulin and the N site GTP in chinese hamster ovary cells

1977 • 138 citations

Phenotypic consequences of tubulin overproduction in Saccharomyces cerevisiae: differences between alpha-tubulin and beta-tubulin.

1990 • 131 citations

Tubulin Folding Cofactors as GTPase-activating Proteins

1999 • 114 citations

Control of the Structural Stability of the Tubulin Dimer by One High Affinity Bound Magnesium Ion at Nucleotide N-site

1998 • 85 citations

Hydrophobic surfaces of tubulin probed by time-resolved and steady-state fluorescence of nile red.

1990 • 85 citations

Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeast

1998 • 81 citations

Determination of free and bound microtubular protein and guanine nucleotide under equilibrium conditions

1979 • 77 citations

Quantitative determination of the proportion of microtubule polymer present during the mitosis-interphase transition

1994 • 76 citations

Exploring Biomolecular Recognition Using Optical Biosensors

1999 • 66 citations

Saccharomyces cerevisiae PAC2 Functions With CIN1, 2 and 4 in a Pathway Leading to Normal Microtubule Stability

1997 • 65 citations

Tubulin folding cofactor D is a microtubule destabilizing protein

2000 • 64 citations

Dominant Effects of Tubulin Overexpression in Saccharomyces cerevisiae

1989 • 62 citations

Effect of colchicine binding on the reversible dissociation of the tubulin dimer

1982 • 61 citations

Chromosome Instability Mutants of Saccharomyces cerevisiae That Are Defective in Microtubule-Mediated Processes

1990 • 59 citations

Cofactor A Is a Molecular Chaperone Required for β-Tubulin Folding: Functional and Structural Characterization

1996 • 58 citations

Phenotypic Consequences of Tubulin Overproduction in Saccharomyces cerevisiae: Differences between Alpha-Tubulin and Beta-Tubulin

1990 • 48 citations

Two Cofactors and Cytoplasmic Chaperonin Are Required for the Folding of α- and β-Tubulin

1993 • 41 citations

Effect of colchicine analogs on the dissociation of .alpha..beta. tubulin into subunits: The locus of colchicine binding

1994 • 39 citations

Rate for nucleotide release from tubulin.

1983 • 39 citations

The Cofactor-Dependent Pathways for α- and β-Tubulins in Microtubule Biogenesis Are Functionally Different in Fission Yeast

2000 • 39 citations

Thermodynamics of reversible monomer-dimer association of tubulin

1991 • 37 citations

Function of Tubulin Binding Proteins in Vivo

2000 • 37 citations

Identification of intrinsic dimer and overexpressed monomeric forms of γ-tubulin in Sf9 cells infected with baculovirus containing the Chlamydomonas γ-tubulin sequence

1995 • 31 citations

Reversible dimer dissociation of tubulin S and tubulin detected by fluorescence anisotropy

1992 • 29 citations

Tubulin dimer dissociation detected by fluorescence anisotropy

1989 • 29 citations

Linkages between the dissociation of .alpha..beta. tubulin into subunits and ligand binding: The ground state of tubulin is the GDP conformation

1994 • 28 citations

Formation and Function of the Rbl2p–β-Tubulin Complex

1998 • 26 citations

Tubulin dimer dissociation and proteolytic accessibility

1989 • 26 citations

An α-Tubulin Mutant Destabilizes the Heterodimer: Phenotypic Consequences and Interactions with Tubulin-binding Proteins

1998 • 24 citations

Aging of Tubulin Monomers Using 5,5'-Bis(8-anilino-1-naphthalenesulfonate) as a Probe

1995 • 23 citations

Reactions of tubulin-associated guanine nucleotides.

1978 • 20 citations

Preparation and characterization of [3H]ethyltubulin

1980 • 19 citations

Tubulin Sorting during Dimerization In Vivo

2001 • 17 citations

Separation of Tubulin Subunits under Nondenaturing Conditions

1998 • 9 citations