T-cell differentiation: Commitment factors for T helper cells

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

1998 • 914 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Regulation of interferon-γ production by IL-12 and IL-18

1998 • 526 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1998 • 228 citations

A “knockdown” mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1

1997 • 228 citations

GATA-3 Significantly Downregulates IFN-γ Production from Developing Th1 Cells in Addition to Inducing IL-4 and IL-5 Levels

1999 • 172 citations

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway

1999 • 111 citations

Genes that regulate interleukin-4 expression in T cells

1997 • 87 citations

Transcriptional control in the Th1/Th2 decision

1997 • 82 citations

T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases

1999 • 81 citations

T-Cell Subsets

1982 • 73 citations

Cutting Edge: Ectopic Expression of the IL-12 Receptor-β2 in Developing and Committed Th2 Cells Does Not Affect the Production of IL-4 or Induce the Production of IFN-γ

2000 • 48 citations