The Drosophila CPEB Homolog, Orb, Is Required for Oskar Protein Expression in Oocytes

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

oskar organizes the germ plasm and directs localization of the posterior determinant nanos

1991 • 804 citations

Induction of germ cell formation by oskar

1992 • 643 citations

staufen, a gene required to localize maternal RNAs in the Drosophila egg

1991 • 612 citations

oskar mRNA is localized to the posterior pole of the Drosophila oocyte

1991 • 574 citations

The intracellular localization of messenger RNAs

1995 • 534 citations

Nanos is the localized posterior determinant in Drosophila

1991 • 510 citations

Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.

1991 • 504 citations

Polarization of both major body axes in Drosophila by gurken-torpedo signalling

1995 • 485 citations

cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila

1995 • 480 citations

Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in drosophila

1986 • 463 citations

CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation

1994 • 451 citations

Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential

1995 • 451 citations

Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner

1994 • 435 citations

Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element.

1989 • 412 citations

tudor, a gene required for assembly of the germ plasm in Drosophila melanogaster

1985 • 401 citations

bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis.

1990 • 394 citations

Localization of nanos RNA controls embryonic polarity

1992 • 391 citations

The maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo

1991 • 349 citations

A role for the Drosophila Bag-of-marbles protein in the differentiation of cystoblasts from germline stem cells

1995 • 345 citations

Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.

1989 • 332 citations

The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.

1994 • 330 citations

The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.

1994 • 320 citations

ISOLATION AND CHARACTERIZATION OF SEX-LINKED FEMALE-STERILE MUTANTS IN DROSOPHILA MELANOGASTER

1975 • 312 citations

Translational regulation of nanos by RNA localization

1994 • 307 citations

The Drosophila posterior-group gene nanos functions by repressing hunchback activity

1989 • 301 citations

Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte

1989 • 291 citations

CPEB controls the cytoplasmic polyadenylation of cyclin, Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus.

1996 • 287 citations

cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo.

1989 • 246 citations

Germline autonomy of maternal-effect mutations altering the embryonic body pattern of Drosophila

1986 • 244 citations

Translational control of oskar generates Short OSK, the isoform that induces pole plasm assembly

1995 • 243 citations

Coordinate Initiation of Drosophila Development by Regulated Polyadenylation of Maternal Messenger RNAs

1994 • 236 citations

Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation

1995 • 232 citations

Chapter 1 On “Masked” Forms of Messenger Rna in Early Embryogenesis and in Other Differentiating Systems

1966 • 221 citations

Translational repressorbruno plays multiple roles in development and is widely conserved

1997 • 213 citations

Cytoplasmic polyadenylation elements mediate masking and unmasking of cyclin B1 mRNA

1999 • 210 citations

Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos

1992 • 205 citations

orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis.

1994 • 187 citations

The Drosophila orb gene is predicted to encode sex-specific germline RNA-binding proteins and has localized transcripts in ovaries and early embryos

1992 • 165 citations

Translational control during early development

1991 • 163 citations

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA

1993 • 162 citations

Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus.

1995 • 159 citations

Translational control by poly(A) elongation during Xenopus development: differential repression and enhancement by a novel cytoplasmic polyadenylation element.

1992 • 156 citations

Profilin is required for posterior patterning of the Drosophila oocyte

1996 • 146 citations

Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein.

1991 • 144 citations

Localization-dependent translation requires a functional interaction between the 5′ and 3′ ends ofoskar mRNA

1998 • 142 citations

Mouse cytoplasmic polyadenylylation element binding protein: An evolutionarily conserved protein that interacts with the cytoplasmic polyadenylylation elements of c- mos mRNA

1996 • 116 citations

Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos

1991 • 115 citations

Localized RNAs and their functions

1993 • 110 citations

Maternal genes required for the anterior localization of bicoid activity in the embryo of Drosophila

1987 • 105 citations

Characterization of the zebrafish Orb/CPEB-related RNA-binding protein and localization of maternal components in the zebrafish oocyte

1998 • 104 citations

Microtubules and Cytoplasm Organization during Drosophila Oogenesis

1994 • 97 citations

tudor, a posterior-group gene of Drosophila melanogaster, encodes a novel protein and an mRNA localized during mid-oogenesis.

1991 • 84 citations

Dual roles of p82, the clam CPEB homolog, in cytoplasmic polyadenylation and translational masking

1999 • 59 citations

Multiple cis-acting targeting sequences are required for orb mRNA localization during Drosophila oogenesis.

1994 • 56 citations

Multiplicity of functions for the otu gene products during Drosophila oogenesis

1988 • 55 citations

Masking and Unmasking Maternal mRNA

1996 • 52 citations

Drosophila virilis oskar transgenes direct body patterning but not pole cell formation or maintenance of mRNA localization in D. melanogaster

1994 • 43 citations

Sex-lethal Interacts with Splicing Factors In Vitro and In Vivo

1996 • 42 citations

A mutation that affects female and male germ cells differentially in Drosophila melanogaster meigen (Diptera: Drosophilidae)

1978 • 40 citations

Establishment of embryonic polarity during Drosophila oogenesis

1995 • 10 citations