Assembly and Antigen-Presenting Function of MHC Class I Molecules in Cells Lacking the ER Chaperone Calreticulin

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Calreticulin: one protein, one gene, many functions

1999 • 726 citations

Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP

1996 • 697 citations

Calreticulin: one protein, one gene, many functions

1999 • 547 citations

Calreticulin Is Essential for Cardiac Development

1999 • 509 citations

Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

1992 • 407 citations

ERp57 Functions as a Subunit of Specific Complexes Formed with the ER Lectins Calreticulin and Calnexin

1999 • 315 citations

Functional specialization of calreticulin domains

2001 • 299 citations

Soluble Tapasin Restores MHC Class I Expression and Function in the Tapasin-Negative Cell Line .220

1998 • 298 citations

HLA-B27–Restricted Antigen Presentation in the Absence of Tapasin Reveals Polymorphism in Mechanisms of HLA Class I Peptide Loading

1998 • 262 citations

Oligosaccharide Binding Characteristics of the Molecular Chaperones Calnexin and Calreticulin

1998 • 260 citations

Calreticulin, a Peptide-binding Chaperone of the Endoplasmic Reticulum, Elicits Tumor- and Peptide-specific Immunity

1999 • 252 citations

Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins

1999 • 251 citations

ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly

1998 • 237 citations

Peptide-induced conformational change of the class I heavy chain

1991 • 221 citations

Impaired Assembly yet Normal Trafficking of MHC Class I Molecules in Tapasin Mutant Mice

2000 • 207 citations

Selective Export of MHC Class I Molecules from the ER after Their Dissociation from TAP

2000 • 194 citations

Impaired immune responses and altered peptide repertoire in tapasin-deficient mice

2000 • 192 citations

A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules

1991 • 188 citations

The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex

1998 • 188 citations

The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules

1991 • 187 citations

TAP‐translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin

1997 • 171 citations

The KDEL receptor mediates a retrieval mechanism that contributes to quality control at the endoplasmic reticulum

2001 • 147 citations

A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules

1998 • 144 citations

Evidence for successive peptide binding and quality control stages during MHC class I assembly

1998 • 140 citations

Point mutations in the α2 domain of HLA-A2.1 define a functionally relevant interaction with TAP

1996 • 130 citations

Calreticulin and Calnexin Interact with Different Protein and Glycan Determinants During the Assembly of MHC Class I

1998 • 121 citations

A Role for Calnexin in the Assembly of the MHC Class I Loading Complex in the Endoplasmic Reticulum

2001 • 111 citations

Calreticulin Displays In Vivo Peptide-Binding Activity and Can Elicit CTL Responses Against Bound Peptides

1999 • 110 citations

Functional Relationship between Calreticulin, Calnexin, and the Endoplasmic Reticulum Luminal Domain of Calnexin

2000 • 106 citations

The Multiple Immune-Evasion Genes of Murine Cytomegalovirus Are Not Redundant

2001 • 103 citations

Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells

1997 • 96 citations

The Role of ERp57 in Disulfide Bond Formation during the Assembly of Major Histocompatibility Complex Class I in a Synchronized Semipermeabilized Cell Translation System

2000 • 84 citations

An extensive region of an MHC class I alpha 2 domain loop influences interaction with the assembly complex.

1999 • 81 citations

Calnexin Influences Folding of Human Class I Histocompatibility Proteins but Not Their Assembly with β2-Microglobulin

1995 • 79 citations

Clustering of Peptide-Loaded MHC Class I Molecules for Endoplasmic Reticulum Export Imaged by Fluorescence Resonance Energy Transfer

2001 • 70 citations

An Extensive Region of an MHC Class I α2 Domain Loop Influences Interaction with the Assembly Complex

1999 • 69 citations

Distinct Patterns of Folding and Interactions with Calnexin and Calreticulin in Human Class I MHC Proteins with Altered N-Glycosylation

1998 • 63 citations

Pivotal Role of Calnexin and Mannose Trimming in Regulating the Endoplasmic Reticulum-associated Degradation of Major Histocompatibility Complex Class I Heavy Chain

2000 • 60 citations

An Endoplasmic Reticulum Protein Implicated in Chaperoning Peptides to Major Histocompatibility of Class I Is an Aminopeptidase

2001 • 59 citations

A Mutant Cell in Which Association of Class I Heavy and Light Chains Is Induced by Viral Peptides

1989 • 55 citations

Peptide-bound Major Histocompatibility Complex Class I Molecules Associate with Tapasin before Dissociation from Transporter Associated with Antigen Processing

1999 • 49 citations

The role of tapasin in MHC class I antigen assembly

1999 • 23 citations

A Soluble Major Histocompatibility Complex Class I Peptide-binding Platform Undergoes a Conformational Change in Response to Peptide Epitopes

1998 • 19 citations

Intracellular transport of class I HLA molecules is affected by polymorphic residues in the binding groove

1994 • 2 citations