Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

1989 • 1,685 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Herpes simplex virus turns off the TAP to evade host immunity

1995 • 736 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP

1996 • 697 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

1995 • 597 citations

Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum.

1989 • 581 citations

The rate of bulk flow from the endoplasmic reticulum to the cell surface

1987 • 542 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid.

1986 • 437 citations

GENERATION, TRANSLOCATION, AND PRESENTATION OF MHC CLASS I-RESTRICTED PEPTIDES

1995 • 428 citations

Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

1989 • 329 citations

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation

1989 • 317 citations

Endocytosis of simian virus 40 into the endoplasmic reticulum.

1989 • 257 citations

Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps.

1995 • 243 citations

Flow cytometry as an analytical and preparative tool in immunology

1982 • 220 citations

Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis.

1991 • 215 citations

Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.

1991 • 213 citations

ATP is required for receptor-mediated endocytosis in intact cells.

1990 • 206 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

The Role of β₂-Microglobulin in Peptide Binding by Class I Molecules

1990 • 179 citations

Trimming of antigenic peptides in an early secretory compartment.

1994 • 169 citations

Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum.

1995 • 163 citations

Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin

1991 • 156 citations

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.

1994 • 151 citations

Dissociation of β2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface

1991 • 132 citations

The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack.

1995 • 129 citations

Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.

1994 • 112 citations

Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells.

1993 • 106 citations

MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains.

1996 • 102 citations

Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.

1990 • 95 citations

Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules

1995 • 91 citations

Capping and receptor‐mediated endocytosis of cell‐bound verotoxin (shiga‐like toxin) 1: Chemical identification of an amino acid in the B subunit necessary for efficient receptor glycolipid binding and cellular internalization

1994 • 80 citations

Recognition of cloned influenza virus hemagglutinin gene products by cytotoxic T lymphocytes

1986 • 79 citations

Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation.

1994 • 48 citations

Analysis of the association of peptides of optimal length to class I molecules on the surface of cells.

1992 • 35 citations

Class I molecules retained in the endoplasmic reticulum bind antigenic peptides.

1993 • 31 citations