Mapping Complex Genetic Traits in Humans: New Methods Using a Complete RFLP Linkage Map

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Analysis of Human Genetic Linkage.

1992 • 1,770 citations

Sequential tests for the detection of linkage.

1955 • 1,590 citations

A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16

1985 • 715 citations

Mendel's Principles of Heredity

1913 • 538 citations

Localization of cystic fibrosis locus to human chromosome 7cen–q22

1985 • 498 citations

Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA Marker

1985 • 488 citations

A closely linked genetic marker for cystic fibrosis

1985 • 463 citations

The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type.

1956 • 434 citations

Abnormality of a Thiamine-Requiring Enzyme in Patients with Wernicke-Korsakoff Syndrome

1977 • 397 citations

Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome

1983 • 394 citations

Use of cyclosporin a in establishing epstein-barr virus-transformed human lymphoblastoid cell lines

1984 • 355 citations

A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7

1985 • 332 citations

Report of the committee on human gene mapping by recombinant DNA techniques

1984 • 274 citations

A NEW ESTIMATE OF THE LINKAGE BETWEEN THE GENES FOR COLOUR‐BLINDNESS AND HAEMOPHILIA IN MAN

1947 • 198 citations

Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms.

1986 • 177 citations

THE DETECTION OF LINKAGE WITH “DOMINANT” ABNORMALITIES

1935 • 104 citations

Genetic Basis of the Epilepsies

1982 • 88 citations

Detecting linkage for genetically heterogeneous diseases and detecting heterogeneity with linkage data.

1986 • 85 citations

Genetic linkage evidence for heterogeneity in Charcot‐Marie‐Tooth neuropathy (HMSN type I)

1983 • 76 citations

Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents.

1982 • 76 citations

Marriage of Two Complete Albinos with Normally Pigmented Offspring

1952 • 51 citations

Linkage evidence for genetic heterogeneity among kinships with hereditary motor and sensory neuropathy, type I.

1983 • 50 citations

Incidence in Italy, genetic heterogeneity, and segregation analysis of cystic fibrosis.

1985 • 48 citations

Complementation analysis of ataxia-telangiectasia.

1985 • 32 citations

Inheritance of Retinoblastoma in Ohio

1959 • 27 citations

Report of the Committee on Human Gene Mapping by Recombinant DNA Techniques (Part 3 of 5)

1985 • 15 citations

A Molecular Approach to Defining the Inherited Components in Epilepsy and Other Diseases of Uncertain Etiology

1984 • 3 citations