Inhibition of Metastasis of Tumor Cells Overexpressing Thymidine Phosphorylase by 2-Deoxy-<scp>l</scp>-Ribose

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis

2003 • 1,261 citations

Anti-Angiogenesis

1972 • 1,167 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Thymidine Phosphorylase Gene Mutations in MNGIE, a Human Mitochondrial Disorder

1999 • 888 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

1986 • 641 citations

Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma

1996 • 367 citations

Mitochondrial neurogastrointestinal encephalomyopathy: An autosomal recessive disorder due to thymidine phosphorylase mutations

2000 • 330 citations

Familial Pyrimidinemia and Pyrimidinuria Associated with Severe Fluorouracil Toxicity

1985 • 254 citations

Role of thymidine phosphorylase activity in the angiogenic effect of platelet-derived endothelial cell growth factor/thymidine phosphorylase

1999 • 226 citations

The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors.

1999 • 207 citations

Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis

1998 • 207 citations

Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.

2000 • 187 citations

The activity and expression of thymidine phosphorylase in human solid tumours

1996 • 182 citations

Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepatectomy.

2000 • 141 citations

Prevention of Hypoxia-Induced Apoptosis by the Angiogenic Factor Thymidine Phosphorylase

1998 • 112 citations

Thymidine Phosphorylase and 2-Deoxyribose Stimulate Human Endothelial Cell Migration by Specific Activation of the Integrins α5β1 and αVβ3

2003 • 78 citations

Interleukin‐8 secreted by endothelial cells induces Chemotaxis of melanoma cells through the chemokine receptor CXCR1

2003 • 77 citations

Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites.

1993 • 71 citations

Suppression of metastasis by thymidine phosphorylase inhibitor.

2000 • 69 citations

Targeted Deletion of Both Thymidine Phosphorylase and Uridine Phosphorylase and Consequent Disorders in Mice

2002 • 61 citations

Molecular Basis for the Inhibition of Hypoxia-Induced Apoptosis by 2-Deoxy-d-ribose

2002 • 61 citations

Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase11Abbreviations: AEAC, 6-(2-aminoethyl)amino-5-chlorouracil; CIMU, 5-chloro-6-(1-imidazolyl-methyl) uracil; FGF, fibroblast growth factor; HUVEC, human umbilical vein endothelial cell(s); PD-ECGF, platelet-derived endothelial cell growth factor; PNP, purine nucleoside phosphorylase; TGF, transforming growth factor; TNF-α, tumor necrosis factor-α; TP, thymidine phosphorylase; UP, uridine …

2001 • 60 citations

Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose.

2002 • 53 citations

The role of thymidine phosphorylase expression in the invasiveness of gastric carcinoma

2000 • 48 citations

Correlation between thymidine phosphorylase expression and invasion phenotype in cervical carcinoma cells

2001 • 31 citations

Rational Design of New Tumoractivated&lt;sup&gt;TM&lt;/sup&gt; Cytotoxic Agents

1999 • 27 citations

Autocrine induction of gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF) and GLS-induced expression of matrix metalloproteinases in rheumatoid arthritis synoviocytes

1999 • 25 citations

The expression of thymidine phosphorylase/platelet‐derived endothelial cell growth factor is correlated to angiogenesis in breast cancer

1998 • 16 citations

Thymidine Phosphorylase Expression in Gallbladder Adenocarcinomas

2002 • 14 citations

Specific simple sugars promote chemotaxis and chemokinesis of corneal endothelial cells

1993 • 12 citations

Domain structure and multiplicity of raw-starch-digesting amylase from Bacillus circulans: extensive proteolysis with proteinase K, endopeptidase Glu-C and thermolysin

1993 • 6 citations