JAK2 Activates TFII-I and Regulates Its Interaction with Extracellular Signal-Regulated Kinase

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

The Role of Hemocytes in <b><i>Anopheles gambiae</i></b> Antiplasmodial Immunity

2013 • 1,046 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 • 964 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics

1999 • 656 citations

Activation of the JAK-STAT pathway by reactive oxygen species

1998 • 566 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Cooperative interaction of an initiator-binding transcription initiation factor and the helix–loop–helix activator USF

1991 • 505 citations

Expression of the c- fos Gene and of an fos -Related Gene Is Stimulated by Platelet-Derived Growth Factor

1984 • 445 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

1998 • 265 citations

p50^cdc37 Acting in Concert with Hsp90 Is Required for Raf-1 Function

1999 • 259 citations

Structural basis for selective inhibition of Src family kinases by PP1

1999 • 249 citations

Mutation in the Jak Kinase JH2 Domain Hyperactivates Drosophila and Mammalian Jak-Stat Pathways

1997 • 248 citations

Platelet-Derived Growth Factor Induces Phosphorylation of Multiple JAK Family Kinases and STAT Proteins

1996 • 247 citations

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

1993 • 246 citations

Distinct Protein Targets for Signals Acting at the c- fos Serum Response Element

1991 • 244 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.

1992 • 219 citations

Cloning of an Inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1

1997 • 195 citations

JAK2, Ras, and Raf Are Required for Activation of Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase by Growth Hormone

1995 • 194 citations

BAP-135, a target for Bruton’s tyrosine kinase in response to B cell receptor engagement

1997 • 182 citations

A duplicated gene in the breakpoint regions of the 7q11.23 Williams- Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK

1998 • 180 citations

An alternative pathway for transcription initiation involving TFII-I

1993 • 166 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

Isolation of ras GTP-binding mutants using an in situ colony-binding assay.

1986 • 153 citations

Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

1998 • 151 citations

Activation of Fes Tyrosine Kinase by gp130, an Interleukin-6 Family Cytokine Signal Transducer, and Their Association

1995 • 147 citations

The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation.

1990 • 146 citations

Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor.

1994 • 142 citations

Activation of c-Raf-1 by Ras and Src through different mechanisms: activationin vivoandin vitro

1997 • 140 citations

A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I

1997 • 136 citations

Regulation of Nuclear Localization and Transcriptional Activity of TFII-I by Bruton’s Tyrosine Kinase

1999 • 110 citations

Beta Interferon and Oncostatin M Activate Raf-1 and Mitogen-Activated Protein Kinase through a JAK1-Dependent Pathway

1997 • 109 citations

TFII-I Enhances Activation of the c-fosPromoter through Interactions with Upstream Elements

1998 • 109 citations

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

1997 • 97 citations

Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ

1996 • 90 citations

Tyrphostin B42 Inhibits IL-12-Induced Tyrosine Phosphorylation and Activation of Janus Kinase-2 and Prevents Experimental Allergic Encephalomyelitis

1999 • 89 citations

The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.

1996 • 84 citations

TFII Is Required for Transcription of the Naturally TATA-less but Initiator-containing Vβ Promoter

1996 • 67 citations

Extracellular Signal-Regulated Kinase Binds to TFII-I and Regulates Its Activation of the c-fosPromoter

2000 • 59 citations

Mitogenic Action of Lysophosphatidic Acid

1991 • 50 citations

Regulation of TFII-I Activity by Phosphorylation

1998 • 47 citations

Two Pathways for Serum Regulation of the c-fos Serum Response Element Require Specific Sequence Elements and a Minimal Domain of Serum Response Factor

1994 • 40 citations

Regulation of Immediate Early Gene Expression

1993 • 39 citations