Macrophage Uptake of Oxidized LDL Inhibits Lysosomal Sphingomyelinase, Thus Causing the Accumulation of Unesterified Cholesterol–Sphingomyelin–Rich Particles in the Lysosomes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

[30] Microsomal lipid peroxidation

1978 • 12,818 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration

1968 • 2,659 citations

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

1976 • 1,032 citations

A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent.

1989 • 594 citations

Plasma Membranes Contain Half the Phospholipid and 90% of the Cholesterol and Sphingomyelin in Cultured Human Fibroblasts

1989 • 509 citations

A defect in cholesterol esterification in Niemann-Pick disease (type C) patients.

1985 • 393 citations

The preferential interactions of cholesterol with different classes of phospholipids

1977 • 374 citations

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

1988 • 323 citations

The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts.

1989 • 306 citations

Study of the Ferric Chloride Method for Determination of Total Cholesterol and Cholesterol Esters

1959 • 264 citations

Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts.

1987 • 249 citations

Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients

1983 • 227 citations

Influence of molecular packing and phospholipid type on rates of cholesterol exchange

1988 • 223 citations

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

1975 • 210 citations

Niemann‐Pick disease group C: clinical variability and diagnosis based on defective cholesterol esterification: A collaborative study on 70 patients

1988 • 183 citations

Practical enzymology of the sphingolipidoses

1977 • 183 citations

Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis

1991 • 170 citations

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

1990 • 162 citations

Plasma Membranes: Phospholipid and Sterol Content

1966 • 149 citations

Formation of cholesterol monohydrate crystals in macrophage-derived foam cells.

1994 • 136 citations

Vitamin E and other Lipophilic Antioxidants Protect LDL against Oxidation

1989 • 134 citations

Type C Niemann-Pick disease. A parallel loss of regulatory responses in both the uptake and esterification of low density lipoprotein-derived cholesterol in cultured fibroblasts.

1986 • 125 citations

Movement of cholesterol between vesicles prepared with different phospholipids or sizes.

1985 • 119 citations

The affinity of cholesterol for phosphatidylcholine and sphingomyelin

1979 • 100 citations

Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Regulation and localization

1991 • 98 citations

Plasma membrane sphingomyelin and the regulation of HMG-CoA reductase activity and cholesterol biosynthesis in cell cultures.

1991 • 92 citations

Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines

1986 • 91 citations

Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester.

1994 • 83 citations

Unesterified cholesterol-rich lipid particles in atherosclerotic lesions of human and rabbit aortas.

1988 • 83 citations

Transfer of cholesterol between liposomal membranes

1979 • 80 citations

Sphingomyelin suppresses the binding and utilization of low density lipoproteins by skin fibroblasts.

1980 • 80 citations

Oxidation of cholesterol moiety of low density lipoprotein in the presence of human endothelial cells or Cu+2 ions: Identification of major products and their effects

1991 • 78 citations

Characterization of two unique cholesterol-rich lipid particles isolated from human atherosclerotic lesions.

1990 • 74 citations

Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.

1994 • 71 citations

Niemann‐Pick disease type C: An update

1991 • 68 citations

Sphingomyelin content of intestinal cell membranes regulates cholesterol absorption. Evidence for pancreatic and intestinal cell sphingomyelinase activity

1992 • 68 citations

Sphingomyelin Lipidosis (Niemann-Pick Disease)

1979 • 66 citations

Electrophoresis and sudan black staining of lipoproteins on gelatinised cellulose acetate

1967 • 53 citations

Hydrolysis of cholesteryl ester in low density lipoprotein converts this lipoprotein to a liposome.

1992 • 53 citations

Low density lipoprotein modification by cholesterol oxidase induces enhanced uptake and cholesterol accumulation in cells.

1992 • 52 citations

Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells

1993 • 44 citations

Long-chain bases in the sphingolipids of atherosclerotic human aorta

1969 • 41 citations

Cholesterol and sphingomyelin syntheses are regulated independently in cultured human intestinal cells, CaCo-2: role of membrane cholesterol and sphingomyelin content.

1993 • 38 citations

Effect of positively charged sphingomyelin liposomes on cholesterol metabolism of cells in culture

1983 • 36 citations

Regulation of phospholipid biosynthesis during cholesterol influx and high density lipoprotein-mediated cholesterol efflux in macrophages

1990 • 32 citations

Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits.

1994 • 26 citations

Inhibition of human fibroblasts sphingomyelinase by cholesterol and 7-dehydrocholesterol

1981 • 26 citations

Effects of drugs on cholesterol esterification in normal and Niemann-Pick type C fibroblasts: AY-9944, other cationic amphiphilic drugs and DMSO

1991 • 22 citations

Lipid composition of low-density lysosomal membrane fraction prepared from atheromatous aorta of cholesterol-fed rabbits.

1983 • 13 citations

Removal of lipoprotein fraction from culture media corrects the reduction of acid sphingomyelinase activity induced by AY9944

1992 • 6 citations