Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1999 • 1,032 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

1998 • 793 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts

1999 • 505 citations

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

2000 • 483 citations

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

1999 • 476 citations

The Respective Contributions of the Mother and Daughter Centrioles to Centrosome Activity and Behavior in Vertebrate Cells

2000 • 462 citations

Cyclin-dependent kinase control of centrosome duplication

1999 • 423 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

Managing the centrosome numbers game: from chaos to stability in cancer cell division

2001 • 402 citations

Re-evaluating centrosome function

2001 • 392 citations

Centrioles in the cell cycle. I. Epithelial cells.

1982 • 362 citations

Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles

1996 • 351 citations

Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression.

2001 • 330 citations

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

1999 • 315 citations

The controlling role of ATM in homologous recombinational repair of DNA damage

2000 • 308 citations

A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

1996 • 304 citations

Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells.

1995 • 301 citations

Mechanism by which caffeine potentiates lethality of nitrogen mustard.

1982 • 294 citations

Caffeine inhibits the checkpoint kinase ATM

1999 • 293 citations

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

1999 • 286 citations

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

2000 • 278 citations

Centrosome amplification and the development of cancer

2002 • 277 citations

Reduced X-Ray Resistance and Homologous Recombination Frequencies in a RAD54 Mutant of the Chicken DT40 Cell Line

1997 • 277 citations

Scc1/Rad21/Mcd1 Is Required for Sister Chromatid Cohesion and Kinetochore Function in Vertebrate Cells

2001 • 267 citations

Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

2002 • 252 citations

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

2000 • 234 citations

Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin.

1988 • 222 citations

Drosophila Checkpoint Kinase 2 Couples Centrosome Function and Spindle Assembly to Genomic Integrity

2003 • 199 citations

Loss of p53 and centrosome hyperamplification

2002 • 184 citations

Centrosome number is controlled by a centrosome-intrinsic block to reduplication

2003 • 183 citations

Centrosome duplication continues in cycloheximide-treated Xenopus blastulae in the absence of a detectable cell cycle.

1990 • 176 citations

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

2004 • 170 citations

Caffeine Inhibits Checkpoint Responses without Inhibiting the Ataxia-Telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) Protein Kinases

2003 • 147 citations

Involvement of Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribosyl)ation in Regulation of Centrosome Function

2003 • 141 citations

The good, the bad and the ugly: the practical consequences of centrosome amplification

2003 • 137 citations

Centrosomes Split in the Presence of Impaired DNA Integrity during Mitosis

2003 • 131 citations

Purification and Characterization of ATM from Human Placenta

2000 • 122 citations

Centriole distribution during tripolar mitosis in Chinese hamster ovary cells.

1984 • 112 citations

Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation

1999 • 108 citations

Protein synthesis and the cell cycle: centrosome reproduction in sea urchin eggs is not under translational control.

1990 • 108 citations

Integration of the centrosome in cell cycle control, stress response and signal transduction pathways

2002 • 99 citations

Caffeine and human DNA metabolism: the magic and the mystery

2003 • 91 citations

A possible role for centrosome overduplication in radiation-induced cell death

2000 • 91 citations

Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells

2003 • 79 citations

GFP-centrin as a marker for centriole dynamics in living cells

2000 • 65 citations

Control mechanisms of the cell cycle: role of the spatial arrangement of spindle components in the timing of mitotic events

1983 • 65 citations

Relationship between nuclear DNA synthesis and centrosome reproduction in sea urchin eggs

1987 • 60 citations

Microtubule-organizing centers abnormal in number, structure, and nucleating activity in x-irradiated mammalian cells.

1983 • 57 citations

Centrioles reveal their secrets

1999 • 19 citations

Centrosome reproduction in Xenopus lysates

2001 • 7 citations