Tumor necrosis factor β (TNF-β) induces binding of the NF-κB transcription factor to a high-affinity κB element in the TNF-β promoter

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Genomic sequencing.

1984 • 8,343 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.

1990 • 900 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.

1989 • 781 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.

1991 • 553 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

1985 • 509 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

1990 • 384 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.

1988 • 308 citations

TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.

1989 • 275 citations

Oligonucleotide that binds nuclear factor NF-kappa B acts as a lymphoid-specific and inducible enhancer element.

1988 • 275 citations

Lymphocyte Cytotoxicity in vitro: Activation and Release of a Cytotoxic Factor

1968 • 266 citations

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes.

1989 • 230 citations

Tumour necrosis factor and lymphotoxin genes map close to H–2D in the mouse major histocompatibility complex

1987 • 230 citations

Tumor Necrosis Factors: Gene Structure and Biological Activities

1986 • 215 citations

NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene.

1990 • 205 citations

Lymphotoxin

1988 • 205 citations

Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancers.

1987 • 184 citations

Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity

1967 • 177 citations

Signaling through T lymphocyte surface proteins, TCR/CD3 and CD28, activates the HIV-1 long terminal repeat.

1989 • 171 citations

A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes.

1987 • 169 citations

Tandem Arrangement of Genes Coding for Tumor Necrosis Factor (TNF- ) and Lymphotoxin (TNF- ) in the Human Genome

1986 • 133 citations

Human T-lymphotropic virus I-infected T cells constitutively express lymphotoxin in vitro

1989 • 99 citations

Signal Transduction in Human T Lymphocytes

1987 • 89 citations

Nuclear factor NF-kappa B can interact functionally with its cognate binding site to provide lymphoid-specific promoter function.

1988 • 77 citations

Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position.

1987 • 71 citations

Nucleotide sequence of the murine TNF locus, including the TNF-α (tumor necrosis factor) and TNF-β (lymphotoxin) genes

1987 • 69 citations

Characterization of specific high affinity receptors for human tumor necrosis factor on mouse fibroblasts.

1985 • 49 citations

Human T cell activation: differential response to anti‐CD28 as compared to anti‐CD3 monoclonal antibodies

1989 • 46 citations

Linkage of TNF genes to the HLA-B locus

1987 • 43 citations

Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and III regions by field inversion gel electrophoresis

1988 • 43 citations

The murine tumor necrosis factor-beta (lymphotoxin) gene sequence

1987 • 34 citations

Alteration of a single nucleotide allows efficient binding of H2TF1/KBF1 to the immunoglobulin kappa enhancer B motif.

1989 • 26 citations

Lymphotoxin cDNA Clones from a HTLV-I-Carrying T Cell Line HUT-102

1989 • 9 citations