L-Type Calcium Channels in Insulin-Secreting Cells: Biochemical Characterization and Phosphorylation in RINm5F Cells

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1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

1989 • 922 citations

Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits.

1993 • 749 citations

Sequence and Expression of mRNAs Encoding the α ₁ and α ₂ Subunits of a DHP-Sensitive Calcium Channel

1988 • 579 citations

Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons

1990 • 512 citations

Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype

1992 • 499 citations

Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle.

1987 • 468 citations

Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.

1992 • 416 citations

Receptor sites for Ca2+ channel antagonists

1992 • 382 citations

Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

1993 • 377 citations

The naming of voltage-gated calcium channels

1994 • 360 citations

Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells

1983 • 304 citations

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.

1995 • 294 citations

Specific Phosphorylation of a Site in the Full-Length Form of the α1 Subunit of the Cardiac L-Type Calcium Channel by Adenosine 3‘,5‘-Cyclic Monophosphate- Dependent Protein Kinase

1996 • 277 citations

Stimulus-secretion coupling in pancreatic β cells

1994 • 251 citations

Cloning and expression of a neuronal calcium channel beta subunit

1993 • 228 citations

Excitation-contraction coupling in vertebrate skeletal muscle: A tale of two calcium channels

1991 • 199 citations

Cloning and expression of a third calcium channel beta subunit.

1993 • 197 citations

Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.

1992 • 195 citations

[42] Assay for calcium channels

1985 • 191 citations

The amino terminus of a calcium channel β subunitsets rates of channel inactivation independently of the subunit's effect on activation

1994 • 191 citations

Voltage-dependent potentiation of the activity of cardiac L-type calcium channel alpha 1 subunits due to phosphorylation by cAMP-dependent protein kinase.

1993 • 189 citations

Cloning and tissue‐specific expression of the brain calcium channel β‐subunit

1991 • 186 citations

Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels.

1990 • 171 citations

Structure and function of voltage-gated ion channels

1993 • 171 citations

Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin.

1988 • 153 citations

Injection of catalytic subunit of cAMP-dependent protein kinase into isolated cardiac myocytes

1983 • 149 citations

Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic β -cells

1989 • 142 citations

Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons.

1995 • 138 citations

Somatostatin inhibits insulin secretion by a G-protein-mediated decrease in Ca2+ entry through voltage-dependent Ca2+ channels in the beta cell.

1991 • 137 citations

Solubilization of the calcium antagonist receptor from rat brain.

1983 • 115 citations

Phosphorylation of the L‐type calcium channel β subunit is involved in β‐adrenergic signal transduction in canine myocardium

1993 • 111 citations

Cyclic AMP‐dependent phosphorylation and regulation of the cardiac dihydropyridine‐sensitive Ca channel

1992 • 109 citations

Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F)

1983 • 103 citations

Protein kinase C modulates the insulin secretory process by maintaining a proper function of the beta-cell voltage-activated Ca2+ channels.

1994 • 98 citations

Association of Native Ca2+ Channel β Subunits with the α1 Subunit Interaction Domain

1995 • 97 citations

Expression of Calcium Channel mRNAs in Rat Pancreatic Islets and Downregulation After Glucose Infusion

1993 • 96 citations

Identification of PK-A Phosphorylation Sites in the Carboxyl Terminus of L-Type Calcium Channel α₁ Subunits

1996 • 93 citations

Stereoselective photoaffinity labelling of the purified 1,4‐dihydropyridine receptor of the voltage‐dependent calcium channel

1986 • 90 citations

Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F).

1991 • 90 citations

Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.

1994 • 81 citations

Localization of the α1 and α2 subunits of the dihydropyridine receptor and ankyrin in skeletal muscle triads

1990 • 81 citations

Specific phosphorylation of a COOH-terminal site on the full-length form of the alpha 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase.

1992 • 71 citations

Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells.

1995 • 70 citations

Dihydropyridine-sensitive and -insensitive voltage-operated calcium channels participate in the control of glucose-induced insulin release from human pancreatic β cells

1996 • 70 citations

Effects of the calcium channel agonist, BAY K 8644, on electrical activity in mouse pancreatic B-cells

1985 • 51 citations

Coordination of Ca2+ by the Pore Region Glutamates Is Essential for High-Affinity Dihydropyridine Binding to the Cardiac Ca2+ Channel a1 Subunit

1995 • 48 citations

A specific G_o heterotrimer couples somatostatin receptors to voltage‐gated calcium channels in RINm5F cells

1996 • 44 citations

Inhibition of serine/threonine protein phosphatases promotes opening of voltage-activated L-type Ca2+ channels in insulin-secreting cells

1994 • 43 citations

Purification and amino-terminal sequencing of the high affinity phenylalkylamine Ca2+ antagonist binding protein from guinea pig liver endoplasmic reticulum.

1994 • 39 citations

Catecholamine modulation of calcium currents in clonal pancreatic beta-cells

1989 • 37 citations

Expression of the L-type calcium channel with two different ? subunits and its modulation by Ro 40-5967

1995 • 34 citations

Molecular diversity and functional characterization of voltage- dependent calcium channels (CACN4) expressed in pancreatic beta-cells

1995 • 29 citations

Molecular Properties of Voltage-Dependent Ca<sup>2+</sup> Channels in Excitable Tissues

1993 • 26 citations

Comparative study of K channel behavior inβ cell lines with different secretory responses to glucose

1989 • 25 citations

Cloning of a novel alpha 1-subunit of the voltage-dependent calcium channel from the beta-cell

1992 • 20 citations

Subunit composition is a major determinant in high affinity binding of a Ca2+ channel blocker.

1996 • 17 citations

Purification of L-Type Calcium Channel Drug Receptors

1991 • 16 citations

Inhibition of L-type calcium channels by internal GTP [?S] in mouse pancreatic ? cells

1992 • 16 citations

KCl-induced insulin secretion from RINm5F cells is mediated through Ca2+ influx along L-type Ca2+ channels

1992 • 14 citations

A single non-L-, non-N-type Ca2+ channel in rat insulin-secreting RINm5F cells

1996 • 13 citations

Binding of the dihydropyridine calcium channel blocker (+)-[3H] isopropyl-4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2, 6-dimethyl-3-pyridinecarboxylate (PN200-110) to RINm5F membranes and cells: characterization and functional significance.

1991 • 12 citations

Up‐regulation of L‐ and non‐L, non‐N‐type Ca²⁺ channels by basal and stimulated protein kinase C activation in insulin‐secreting RINm5F cells

1996 • 11 citations

Nutrient and pharmacological stimulation of insulin‐secreting cells: marked differences in the onset of electrical activity

1990 • 9 citations