Mapping of a second actin-tropomyosin and a second troponin C binding site within the C terminus of troponin I, and their importance in the Ca2+-dependent regulation of muscle contraction

The Regulation of Rabbit Skeletal Muscle Contraction

1971 • 4,491 citations

Calcium and muscle contraction

1968 • 1,745 citations

Carp Muscle Calcium-binding Protein

1973 • 1,359 citations

Separation of subfragment-1 isoenzymes from rabbit skeletal muscle myosin

1975 • 1,047 citations

A new and convenient colorimetric determination of inorganic orthophosphate and its application to the assay of inorganic pyrophosphatase

1981 • 891 citations

Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

1985 • 619 citations

Reconstitution of Troponin Activity from Three Protein Components

1971 • 594 citations

The troponin complex and regulation of muscle contraction

1995 • 564 citations

Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

1987 • 529 citations

Molecular Structure of Troponin C from Chicken Skeletal Muscle at 3-Angstrom Resolution

1985 • 342 citations

Troponin and Its Components*

1971 • 332 citations

Purification and Properties of the Components from Troponin

1973 • 329 citations

A model for the Ca2+-induced conformational transition of troponin C. A trigger for muscle contraction.

1986 • 323 citations

The amino acid sequence of rabbit skeletal muscle troponin C: Gene replication and homology with calcium ‐binding proteins from carp and hake muscle

1973 • 266 citations

The relationship between biological activity and primary structure of troponin I from white skeletal muscle of the rabbit

1976 • 246 citations

Structures of the troponin C regulatory domains in the apo and calcium-saturated states

1995 • 218 citations

Structural and regulatory functions of the NH2- and COOH-terminal regions of skeletal muscle troponin I.

1994 • 213 citations

A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca2+ Regulation of Muscle Contraction

1995 • 169 citations

NMR solution structure of calcium-saturated skeletal muscle troponin C

1995 • 164 citations

Synthetic studies on the inhibitory region of rabbit skeletal troponin I. Relationship of amino acid sequence to biological activity.

1981 • 145 citations

Molecular mechanism of troponin-C function

1992 • 140 citations

Proteolytic fragments of troponin C. Interactions with the other troponin subunits and biological activity.

1981 • 137 citations

Quantification of the calcium‐induced secondary structural changes in the regulatory domain of troponin‐C

1994 • 132 citations

Calcium-Induced Movement of Troponin-I Relative to Actin in Skeletal Muscle Thin Filaments

1990 • 131 citations

A new method of preparation of troponin I (inhibitory protein) using affinity chromatography. Evidence for three different forms of troponin I in striated muscle

1974 • 124 citations

The biological importance of each amino acid residue of the troponin I inhibitory sequence 104-115 in the interaction with troponin C and tropomyosin-actin.

1988 • 113 citations

Reversed-phase chromatography of synthetic amphipathic α-helical peptides as a model for ligand/receptor interactions Effect of changing hydrophobic environment on the relative hydrophilicity/hydrophobicity of amino acid side-chains

1994 • 109 citations

Inhibition of mutant troponin C activity by an intra-domain disulphide bond

1990 • 102 citations

Probing the calcium-induced conformational transition of troponin C with site-directed mutants

1990 • 99 citations

Localization and Mode of Action of the Inhibitory Protein Component of the Troponin Complex

1973 • 92 citations

Fragments of rabbit striated muscle alpha-tropomyosin. I. Preparation and characterization.

1981 • 89 citations

NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex.

1994 • 84 citations

Characterization of a region of the primary sequence of troponin C involved in calcium ion-dependent interaction with troponin I

1978 • 82 citations

Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal peptide in myofilament activation.

1994 • 80 citations

Interaction of troponin I and troponin C

1991 • 78 citations

Selective oxidation and reduction of methionine residues in peptides and proteins by oxygen exchange between sulfoxide and sulfide.

1986 • 77 citations

Distinct Regions of Troponin I Regulate Ca2+-dependent Activation and Ca2+ Sensitivity of the Acto-S1-TM ATPase Activity of the Thin Filament

1997 • 76 citations

Isolation, expression, and mutation of a rabbit skeletal muscle cDNA clone for troponin I. The role of the NH2 terminus of fast skeletal muscle troponin I in its biological activity.

1992 • 73 citations

Characterization of zero-length cross-links between rabbit skeletal muscle troponin C and troponin I: evidence for direct interaction between the inhibitory region of troponin I and the amino-terminal, regulatory domain of troponin C

1990 • 73 citations

Calmodulin and troponin C: a comparative study of the interaction of mastoparan and troponin I inhibitory peptide [104-115]

1986 • 65 citations

Interaction between troponin I and troponin C

1982 • 61 citations

Calcium-dependent inhibitory region of troponin: a proton nuclear magnetic resonance study on the interaction between troponin C and the synthetic peptide N.alpha.-acetyl[FPhe106]TnI-(104-115) amide

1983 • 61 citations

Evidence that both Ca(2+)-specific sites of skeletal muscle TnC are required for full activity.

1990 • 59 citations

Crosslinking of rabbit skeletal muscle troponin with the photoactive reagent 4-maleimidobenzophenone: identification of residues in troponin I that are close to cysteine-98 of troponin C

1987 • 59 citations

The interaction of rabbit skeletal muscle troponin-T fragments with troponin-I

1985 • 59 citations

Synthesis and biological activity of an icosapeptide analog of the actomyosin ATPase inhibitory region of troponin I.

1979 • 53 citations

Effects of calcium and subunit interactions on surface accessibility of cysteine residues in cardiac troponin

1988 • 51 citations

Study of the structure of troponin-C by measuring the relative reactivities of lysines with acetic anhydride

1981 • 49 citations

Structure of the troponin complex. Implications of photocross-linking of troponin I to troponin C thiol mutants.

1994 • 48 citations

Calcium dependence of the distance between Cys-98 of troponin C and Cys-133 of troponin I in the ternary troponin complex. Resonance energy transfer measurements

1989 • 45 citations

Cross-linking of rabbit skeletal muscle troponin subunits: labeling of cysteine-98 of troponin C with 4-maleimidobenzophenone and analysis of products formed in the binary complex with troponin T and the ternary complex with troponins I and T

1988 • 45 citations

Ca2(+)-dependent interactions between the C-helix of troponin-C and troponin-I. Photocross-linking and fluorescence studies using a recombinant troponin-C.

1990 • 45 citations

Cross-linking of residue 57 in the regulatory domain of a mutant rabbit skeletal muscle troponin C to the inhibitory region of troponin I

1991 • 44 citations

Interaction of troponin C and troponin C fragments with troponin I and the troponin I inhibitory peptide

1992 • 43 citations

Photochemical cross-linking between rabbit skeletal troponin subunits. Troponin I-troponin T interactions.

1982 • 40 citations

Solution conformation of the C‐terminal domain of skeletal troponin C

1985 • 38 citations

A synthetic peptide mimics troponin I function in the calcium‐dependent regulation of muscle contraction

1993 • 35 citations

Ca2+, Mg2+, and Troponin I Inhibitory Peptide Binding to a Phe-154 to Trp Mutant of Chicken Skeletal Muscle Troponin C

1994 • 35 citations

Biologically important interactions between synthetic peptides of the N-terminal region of troponin I and troponin C.

1992 • 33 citations

Photochemical cross-linking between native rabbit skeletal troponin C and benzoylbenzoyl-troponin I inhibitory peptide, residues 104-115.

1994 • 31 citations

Solution secondary structure of calcium‐saturated troponin C monomer determined by multidimensional heteronuclear NMR spectroscopy

1995 • 28 citations

Evidence for Two-Site Binding of Troponin I Inhibitory Peptides to the N and C Domains of Troponin C

1995 • 28 citations

Inhibition of rabbit skeletal muscle acto‐S1 ATPase by troponin T

1983 • 24 citations

Interactions of troponin I and its inhibitory fragment (residues 104-115) with troponin C and calmodulin

1989 • 24 citations

An NMR and spin label study of the effects of binding calcium and troponin I inhibitory peptide to cardiac troponin C

1995 • 20 citations

Interaction of a troponin I inhibitory peptide with both domains of troponin C

1996 • 19 citations

Photo-Cross-Linking of Rabbit Skeletal Troponin I Deletion Mutants with Troponin C and Its Thiol Mutants: The Inhibitory Region Enhances Binding of Troponin I Fragments to Troponin C

1996 • 19 citations

Proteolytic separation of an enzymic active subfragment from the myosin-subfragment (S-1)

1967 • 19 citations

A ¹H NMR study of a ternary peptide complex that mimics the interaction between troponin C and troponin I

1992 • 16 citations

1H-NMR Study of Ca2+- and Mg2+-Dependent Interaction between Troponin C and Troponin I Inhibitory Peptide (96–116)1

1992 • 13 citations

Interaction of troponin I and troponin C: ¹⁹F NMR studies of the binding of the inhibitory troponin I peptide to turkey skeletal troponin C

1991 • 10 citations

Deleted Work

1955 • 0 citations