Repeated Intravenous Administration of Liposome-Encapsulated Muramyl Tripeptide-Phosphatidyl-Ethanolamine Diminishes Cytotoxic Potential of Subpopulations of Rat Liver Macrophages

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

On the Encoding of Arbitrary Geometric Configurations

1961 • 1,667 citations

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

1985 • 1,605 citations

Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives

1974 • 1,038 citations

Cells of the hepatic sinusoid

1989 • 589 citations

Cells of the hepatic sinusoid

1998 • 557 citations

Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1.

1994 • 517 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Macrophages and metastasis--a biological approach to cancer therapy.

1985 • 354 citations

Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery.

1982 • 303 citations

Therapy for Osteosarcoma in Dogs With Intravenous Injection of Liposome-Encapsulated Muramyl Tripeptide

1989 • 220 citations

Distribution‐free estimation of sphere size distributions from slabs showing overprojection and truncation, with a review of previous methods

1983 • 196 citations

Relation between localization and function of rat liver Kupffer cells.

1982 • 184 citations

Phase II study of liposomal muramyl tripeptide in osteosarcoma: the cytokine cascade and monocyte activation following administration.

1992 • 151 citations

The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasone

1988 • 140 citations

Activation of tumoricidal properties in human blood monocytes by liposomes containing lipophilic muramyl tripeptide.

1983 • 138 citations

Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression.

1989 • 116 citations

Phase I trial of liposomal muramyl tripeptide phosphatidylethanolamine in cancer patients.

1989 • 108 citations

UPTAKE OF LIPOSOMES BY RAT AND MOUSE HEPATOCYTES AND KUPFFER CELLS

1983 • 94 citations

Immunohistochemical demonstration of DNA-incorporated 5-bromodeoxyuridine in frozen and plastic embedded sections

1986 • 89 citations

Activation or suppression of the tumoricidal properties of monocytes from cancer patients following treatment with human recombinant gamma-interferon.

1986 • 86 citations

In vitro activation of rat liver macrophages to tumoricidal activity by free or liposome-encapsulated muramyl dipeptide.

1986 • 82 citations

Isolation of Tumoricidal Macrophages From Lung Melanoma Metastases of Mice Treated Systemically With Liposomes Containing a Lipophilic Derivative of Muramyl Dipeptide<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref><xref ref-type="fn" rid="fn4">4</xref>

1982 • 80 citations

Kupffer cells and liver metastasis

1989 • 58 citations

Initial clinical trial of the macrophage activator muramyl tripeptide-phosphatidylethanolamine encapsulated in liposomes in patients with advanced cancer.

1990 • 46 citations

Optimization and limitations of systemic treatment of murine melanoma metastases with liposomes containing muramyl tripeptide phosphatidylethanolamine

1986 • 46 citations

The in situ activation of cytotoxic properties in murine Kupffer cells by the systemic administration of whole Mycobacterium bovis organisms or muramyl tripeptide

1984 • 41 citations

Therapy of autochthonous skin cancers in mice with intravenously injected liposomes containing muramyltripeptide.

1986 • 40 citations

Inhibition of experimental liver tumor growth in mice by liposomes containing a lipophilic muramyl dipeptide derivative.

1989 • 39 citations

Activation of murine kupffer cell tumoricidal activity by liposomes containing lipophilic muramyl dipeptide

1988 • 37 citations

Inhibition of murine hepatic tumor growth by liposomes containing a lipophilic muramyl dipeptide

1989 • 31 citations

MDP and LPS act synergistically to induce arginine-dependent cytostatic activity in rat alveolar macrophages

1991 • 26 citations

Gadolinium chloride-induced shifts in intrahepatic distributions of liposomes

1989 • 26 citations

Therapy of Murine Liver Metastases by Administration of MDP Encapsulated in Liposomes

1990 • 26 citations

Potent in situ activation of murine lung macrophages and therapy of melanoma metastases by systemic administration of liposomes containing muramyltripeptide phosphatidylethanolamine and interferon gamma.

1989 • 24 citations

Endocytic and Tumoricidal Heterogeneity of Rat Liver Macrophage Populations

1989 • 21 citations

Muramyl peptide‐binding sites are located inside target cells

1991 • 19 citations

Functional Characteristics of the Rat Liver Macrophage Population After a Single Intravenous Injection of Liposome-Encapsulated Muramyl Peptides

1993 • 17 citations

HIS-19 - A MONOCLONAL-ANTIBODY RECOGNIZING A CLASS-II POLYMORPHIC DETERMINANT ONLY ABSENT ON RT1N CLASS-II ANTIGENS

1985 • 17 citations

Muramyldipeptide and granulocyte-macrophage colony-stimulating factor enhance interferon-γ-induced nitric oxide production by rat alveolar macrophages

1993 • 16 citations

Liposomal muramyl dipeptide therapy of experimental M5076 liver metastases in mice

1991 • 15 citations

In situ activation of mouse macrophages and therapy of spontaneous renal cell cancer metastasis by liposomes containing the lipopeptide CGP 31362

1991 • 15 citations

Secretion Pattern of the Rat Liver Macrophage Population Following Activation with Liposomal Muramyl Dipeptide In Vivo and In Vitro

1994 • 12 citations

Induction of murine macrophage tumoricidal activity and treatment of experimental pulmonary metastases by liposomes containing lipophilic muramyl dipeptide analogs.

1987 • 12 citations

Population kinetics of rat liver macrophages after intravenous administration of liposome-encapsulated MDP

1989 • 9 citations

TUMORCYTOLYTIC ACTIVITY AND TNF SECRETION OF THE RAT-LIVER MACROPHAGE POPULATION AFTER INTRAVENOUS ADMINISTRATION OF LIPOSOME-ENCAPSULATED MDP

1991 • 3 citations