Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoproteinE‐deficient mice

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

[42] Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal

1990 • 3,220 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

Glutathione-ascorbic acid antioxidant system in animals

1994 • 825 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

1998 • 509 citations

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

1994 • 498 citations

[1] Glutathione metabolism

1995 • 406 citations

Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

1995 • 403 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

1998 • 354 citations

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

1999 • 340 citations

Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe^−/−Mice: Isoform-Specific Effects on Neurodegeneration

1999 • 283 citations

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype

1999 • 238 citations

Research advances in Alzheimer's disease and related disorders

1995 • 230 citations

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice

1995 • 218 citations

Lipoprotein Uptake by Neuronal Growth Cones in Vitro

1987 • 209 citations

Induction of Reactive Oxygen Species in Neurons by Haloperidol

1998 • 195 citations

Proatherogenic and Antiatherogenic Effects of Probucol and Phytosterols in Apolipoprotein E–Deficient Mice

1999 • 176 citations

Increased Plasma and Lipoprotein Lipid Peroxidation in apo E-Deficient Mice

1994 • 172 citations

Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE

1997 • 148 citations

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

1997 • 142 citations

Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease

1994 • 126 citations

In Vivo Uptake of Radiolabeled MDA2, an Oxidation-Specific Monoclonal Antibody, Provides an Accurate Measure of Atherosclerotic Lesions Rich in Oxidized LDL and Is Highly Sensitive to Their Regression

2000 • 121 citations

Antiatherosclerotic and Antioxidative Effects of Captopril in Apolipoprotein E-Deficient Mice

1998 • 111 citations

Effect of the Antioxidant N,N′ -Diphenyl 1,4-Phenylenediamine (DPPD) on Atherosclerosis in ApoE-Deficient Mice

1995 • 106 citations

Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice

1999 • 99 citations

Crosslinking of Apolipoprotein E by Products of Lipid Peroxidation

1996 • 93 citations

ALTERATIONS IN APOLIPOPROTEIN E EXPRESSION DURING AGING AND NEURODEGENERATION

1996 • 88 citations

Reduced Levels of Antioxidants in Brains of Apolipoprotein E-Deficient Mice Following Closed Head Injury

1997 • 73 citations

M₁ Muscarinic Agonist Treatment Reverses Cognitive and Cholinergic Impairments of Apolipoprotein E‐Deficient Mice

1998 • 71 citations

Protection against developmental retardation in apolipoprotein E-deficient mice by a fatty neuropeptide: Implications for early treatment of Alzheimer's disease

1997 • 63 citations

Dietary β-Carotene and α-Tocopherol Combination Does Not Inhibit Atherogenesis in an ApoE–Deficient Mouse Model

1999 • 59 citations

Viral Persistence in Neurons Alters Synaptic Plasticity and Cognitive Functions without Destruction of Brain Cells

1996 • 59 citations

Increased 3-nitrotyrosine in brains of Apo E-deficient mice

1996 • 59 citations

Time-dependent changes to lipids and antioxidants in plasma and aortas of apolipoprotein E knockout mice

1999 • 58 citations

Brains of Aged Apolipoprotein E‐Deficient Mice Have Increased Levels of F₂‐Isoprostanes, In Vivo Markers of Lipid Peroxidation

1999 • 55 citations

Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury

1999 • 52 citations

Apolipoprotein E and Alzheimer's disease

1994 • 46 citations

Altered long-term potentiation in the hippocampus of apolipoprotein E-deficient mice

1998 • 44 citations

Increased Cerebral Cortical Lipid Peroxidation and Abnormal Phospholipids in Aged Homozygous apoE-Deficient C57BL/6J Mice

1999 • 39 citations