Effect of Aging on Brain-Derived Neurotrophic Factor, proBDNF, and Their Receptors in the Hippocampus of Lou/C Rats
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References (70)
Primer3 on the WWW for General Users and for Biologist Programmers
2003 • 15,242 citations
Neurotrophin signal transduction in the nervous system
2000 • 1,910 citations
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
1995 • 1,416 citations
NEUROTROPHINS AND SYNAPTIC PLASTICITY
1999 • 1,343 citations
Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
1996 • 1,219 citations
Trk receptors: mediators of neurotrophin action
2001 • 1,051 citations
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
2005 • 927 citations
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus
2001 • 925 citations
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease
2001 • 851 citations
trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.
1991 • 785 citations
Oxidatively modified proteins in aging and disease1,2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.
2002 • 764 citations
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
1990 • 748 citations
Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
2003 • 711 citations
Carbonyl modified proteins in cellular regulation, aging, and disease2,3 2Guest Editor: Earl Stadtman 3This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.
2002 • 637 citations
Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines
2008 • 604 citations
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
1989 • 604 citations
An absolute method for protein determination based on difference in absorbance at 235 and 280 nm
1980 • 592 citations
The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system
2002 • 584 citations
Neurotrophins and brain insults
1994 • 564 citations
Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor
2001 • 538 citations
New insights into brain BDNF function in normal aging and Alzheimer disease
2008 • 537 citations
Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling
1996 • 472 citations
Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation
2002 • 455 citations
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
1999 • 452 citations
Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas
2006 • 387 citations
Physiology of BDNF: focus on hypothalamic function
2004 • 360 citations
Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells
2003 • 355 citations
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
2008 • 340 citations
The role of AGEs in aging: causation or correlation
2001 • 321 citations
The many faces of p75NTR
2002 • 309 citations
Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats
2008 • 298 citations
Activity‐dependent and hormonal regulation of neurotrophin mRNA levels in brain–implications for neuronal plasticity
1994 • 297 citations
Distribution of Brain‐Derived Neurotrophic Factor in Rats and Its Changes with Development in the Brain
1997 • 291 citations
Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor
2000 • 286 citations
Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth
2000 • 278 citations
Neurotrophins
2002 • 272 citations
Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development
1995 • 270 citations
Neurotrophins and activity-dependent plasticity
2000 • 257 citations
Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions
1995 • 247 citations
Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer’s disease
2003 • 244 citations
Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats
1997 • 226 citations
Signal Transduction Mediated by the Truncated trkB Receptor Isoforms, trkB.T1 and trkB.T2
1997 • 224 citations
Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice
2003 • 222 citations
Age-related changes in brain-derived neurotrophic factor and tyrosine kinase receptor isoforms in the hippocampus and hypothalamus in male rats
2005 • 205 citations
The uniqueness of being a neurotrophin receptor
2001 • 194 citations
Neurons, glia, and plasticity in normal brain aging
2003 • 168 citations
Neurotrophic Factor Receptors and Their Signal Transduction Capabilities in Rat Astrocytes
1994 • 164 citations
Down-regulation of the Neurotrophin Receptor TrkB following Ligand Binding
2000 • 160 citations
Truncated trkB Receptors on Nonneuronal Cells Inhibit BDNF-Induced Neurite Outgrowthin Vitro
1997 • 142 citations
Stem Cell Review Series: Role of neurogenesis in age‐related memory disorders
2008 • 135 citations
Molecular mechanisms of synaptic plasticity and memory
1999 • 133 citations
Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS
1995 • 128 citations
Truncated trkB.T1 Is Dominant Negative Inhibitor of trkB.TK+-Mediated Cell Survival
2001 • 127 citations
BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events
2004 • 118 citations
Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats
2001 • 117 citations
Astrocyte changes in aging cerebral cortex and hippocampus: A quantitative immunohistochemical study
1998 • 104 citations
Synaptic plasticity in early aging
2006 • 99 citations
Effects of alcohol on brain-derived neurotrophic factor mRNA expression in discrete regions of the rat hippocampus and hypothalamus
2001 • 92 citations
Memory and its role in appetite regulation
2005 • 89 citations
Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats
2007 • 89 citations
The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC
2005 • 88 citations
The LOU/c/jall Rat as an Animal Model of Healthy Aging?
2002 • 70 citations
Changes in Pattern of Macronutrient Intake During Aging in Male and Female Rats
1997 • 59 citations
Preserved memory capacities in aged Lou/C/Jall rats
2008 • 45 citations
Strain differences in hypothalamic–pituitary–adrenocortical axis function and adipogenic effects of corticosterone in rats
2007 • 34 citations
Resistance to obesity in Lou/C rats prevents ageing-associated metabolic alterations
2003 • 30 citations
Delayed Age-Associated Decrease in Growth Hormone Pulsatile Secretion and Increased Orexigenic Peptide Expression in the Lou C/Jall Rat
2004 • 27 citations
Metabolic Characteristics and Body Composition in a Model of Anti‐Obese Rats (Lou/C)
2002 • 25 citations
Effect of Aging on Rat Tissue Peptidase Activities
2003 • 19 citations
Circulating hormones and hypothalamic energy balance: regulatory gene expression in the Lou/C and Wistar rats
2006 • 13 citations