Identification of the In Vivo Casein Kinase II Phosphorylation Site within the Homeodomain of the Cardiac Tisue-Specifying Homeobox Gene Product Csx/Nkx2.5

Molecular biology of the cell

1993 • 2,383 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

HOMEODOMAIN PROTEINS

1994 • 828 citations

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

1993 • 790 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

1997 • 660 citations

Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation

1995 • 622 citations

NK-2Homeobox Genes and Heart Development

1996 • 574 citations

Csx: a murine homeobox-containing gene specifically expressed in the developing heart.

1993 • 533 citations

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

1995 • 511 citations

Induction of avian cardiac myogenesis by anterior endoderm

1995 • 475 citations

Guidebook to the homeobox genes

1994 • 399 citations

What determines the specificity of action of Drosophila homeodomain proteins?

1990 • 357 citations

The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.

1991 • 351 citations

Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.

1997 • 323 citations

Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation

1996 • 317 citations

RNA binding and translational suppression by bicoid

1996 • 313 citations

GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression

1998 • 303 citations

Nuclear protein import

1997 • 296 citations

Identification of Novel DNA Binding Targets and Regulatory Domains of a Murine Tinman Homeodomain Factor, nkx-2.5

1995 • 289 citations

Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis

1987 • 282 citations

The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression

1998 • 274 citations

CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway

1997 • 273 citations

Casein kinases: pleiotropic mediators of cellular regulation

1993 • 264 citations

Mitotic Phosphorylation of the Oct-1 Homeodomain and Regulation of Oct-1 DNA Binding Activity

1991 • 237 citations

XNkx-2.5, a Xenopus Gene Related to Nkx-2.5 and tinman: Evidence for a Conserved Role in Cardiac Development

1994 • 219 citations

The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.

1994 • 207 citations

Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements

1991 • 206 citations

Regulation of transcription factor localization: fine-tuning of gene expression

1996 • 177 citations

Guidebook to the Hoineobox Genes

1994 • 161 citations

Cardiac and Extracardiac Expression of Csx/Nkx2.5 Homeodomain Protein

1998 • 157 citations

The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase

1998 • 152 citations

Regulation of segmentation and segmental identity byDrosophilahomeoproteins: the role of DNA binding in functional activity and specificity

1997 • 130 citations

The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells

1990 • 124 citations

A comprehensive classification of homeobox genes

1994 • 124 citations

Nuclear import of the homeodomain protein Extradenticle in response to Wg and Dpp signalling

1996 • 121 citations

Activation of the cardiac α-actin promoter depends upon serum response factor,Tinman homologue, Nkx-2.5, and intact serum response elements

1996 • 120 citations

A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila.

1997 • 119 citations

Enhanced casein kinase II activity during mouse embryogenesis

1986 • 114 citations

Toward the molecular dissection of protein import into nuclei

1996 • 112 citations

Phosphorylation of the MADS-Box Transcription Factor MEF2C Enhances Its DNA Binding Activity

1996 • 108 citations

Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal.

1990 • 87 citations

Removal of dodecyl sulfate from protein solution

1988 • 82 citations

Mapping and Functional Role of Phosphorylation Sites in the Thyroid Transcription Factor-1 (TTF-1)

1996 • 79 citations

Molecular Cloning and Characterization of Human Cardiac Homeobox Gene CSX1

1996 • 73 citations

Identification of the Nuclear Localization Signal of the POU Domain Protein Tst-1/Oct6

1996 • 71 citations

DNA Binding by Cut Homeodomain Proteins Is Down-modulated by Protein Kinase C

1996 • 67 citations

Chicken Nkx-2.8: A Novel Homeobox Gene Expressed in Early Heart Progenitor Cells and Pharyngeal Pouch-2 and -3 Endoderm

1997 • 66 citations

M-Phase-Specific Phosphorylation of the POU Transcription Factor GHF-1 by a Cell Cycle-Regulated Protein Kinase Inhibits DNA Binding

1995 • 65 citations

Phosphorylation of the Drosophila Engrailed Protein at a Site Outside Its Homeodomain Enhances DNA Binding

1995 • 64 citations

Molecular Cloning, Chromosomal Mapping, and Characterization of the Human Cardiac-Specific Homeobox Gene hCsx

1996 • 56 citations

Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster.

1991 • 54 citations

DNA Binding by Cut Homeodomain Proteins Is Down-modulated by Casein Kinase II

1998 • 51 citations

Nuclear localization domain of thyroid transcription factor-1 in respiratory epithelial cells

1997 • 49 citations

TheDrosophila engrailedprotein is phosphorylated by a serine-specific protein kinase

1988 • 47 citations

Phosphorylation, expression and function of the Ultrabithorax protein family in Drosophila melanogaster

1991 • 39 citations

Cardiac myogenesis: overexpression of XCsx2 or XMEF2A in whole Xenopus embryos induces the precocious expression of XMHC? gene

1995 • 29 citations

Identification of the Thyroid Transcription Factor-1 as a Target for Rat MST2 Kinase

1998 • 18 citations