Epithelial Tumor Markers: Oncofetal Antigens (Carcinoembryonic Antigen, Alpha Fetoprotein) and Epithelial Membrane Antigen

PRODUCTION OF EMBRYONAL α-GLOBULIN BY TRANSPLANTABLE MOUSE HEPATOMAS

1963 • 601 citations

Demonstration of a New Protein Fraction in Serum from the Human Fetus

1956 • 468 citations

Carcinoembryonic Antigen

1986 • 445 citations

Distribution of epithelial membrane antigen in normal and neoplastic tissues and its value in diagnostic tumor pathology

1981 • 404 citations

Identification of an Antigen from Normal Human Tissue That Crossreacts with the Carcinoembryonic Antigen

1972 • 376 citations

A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue.

1979 • 329 citations

Alpha-Fetoprotein 3

1978 • 297 citations

Sites of Serum α-Fetoprotein Synthesis in the Human and in the Rat*

1967 • 291 citations

HUMAN LYMPHOID CELLS EXPRESS EPITHELIAL MEMBRANE ANTIGEN

1984 • 274 citations

Cea-related antigens: Molecular biology and clinical significance

1985 • 268 citations

Carcinoembryonic antigen (CEA): Demonstration of a partial identify between CEA and a normal glycoprotein

1972 • 259 citations

Mesothelioma: profile of keratin proteins and carcinoembryonic antigen: an immunoperoxidase study of 20 cases and comparison with pulmonary adenocarcinomas.

1982 • 222 citations

Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment.

1984 • 217 citations

Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor‐cell differentiation

1972 • 184 citations

Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues.

1985 • 177 citations

Immunocytochemical detection of carcinoembryonic antigen in conventional histopathology specimens

1978 • 162 citations

α Foetoprotein and serum albumin show sequence homology

1976 • 160 citations

Ultrastructural localization of carcinoembryonic antigen in normal intestine and colon cancer. Abnormal distribution of cea on the surfaces of colon cancer cells

1982 • 159 citations

Hepatocyte proliferation and alpha 1-fetoprotein in pregnant, neonatal, and partially hepatectomized rats.

1974 • 157 citations

Production of alpha-fetoprotein, normal serum proteins, and human chorionic gonadotropin in stomach cancer: Histologic and immunohistochemical analyses of 35 cases

1981 • 157 citations

Carcinoembryonic antigen‐like substances of human bile. Isolation and partial characterization

1976 • 157 citations

Monoclonal antibodies identify a cea crossreacting antigen of 95 kD (NCA‐95) distinct in antigenicity and tissue distribution from the previously described NCA of 55 kD

1984 • 151 citations

Calcitonin and Carcinoembryonic Antigen as Tumor Markers in Medullary Thyroid Carcinoma

1978 • 149 citations

Characterization of a Second Normal Antigen that Cross-Reacts with CEA

1973 • 147 citations

Distribution of five antigens in hepatocellular carcinoma.

1979 • 130 citations

Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure.

1987 • 130 citations

Carcinoembryonic Antigen (CEA) and Carbohydrate Determinant 19–9 (CA 19–9) Localization in 121 Primary and Metastatic Ovarian Tumors

1982 • 127 citations

Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: a systematic approach for the determination of epitope specificities of monoclonal antibodies.

1983 • 121 citations

α‐Fetoprotein as a Marker of Embryo‐Specific Differentiations in Normal and Tumor Tissues

1974 • 121 citations

Immunofluorescent study of alpha‐foetoprotein (αfp) in liver and liver tumours. I. Technique of αfp localization in tissue sections

1971 • 114 citations

α-Fetoprotein in Nonneoplastic Hepatic Disorders

1975 • 110 citations

Role of Serial Plasma C.E.A. Assays in Detection of Recurrent and Metastatic Colorectal Carcinomas

1974 • 108 citations

Immunocytochemical Localization of Carcinoembryonic Antigen in Benign and Malignant Colorectal Tissues: Assessment of Diagnostic Value

1981 • 108 citations

Biochemical Monitoring of Cancer: A Review

1976 • 105 citations

Epithelial membrane antigen: Partial purification, assay and properties

1983 • 98 citations

Are Keratin Proteins a Better Tumor Marker than Epithelial Membrane Antigen?: A Comparative Immunohistochemical Study of Various Paraffin-Embedded Neoplasms Using Monoclonal and Polyclonal Antibodies

1986 • 96 citations

Demonstration of carcinoembryonic antigen in human breast carcinomas by the immunoperoxidase technique.

1980 • 90 citations

Carcinoembryonic antigen in breast-cancer tissue: a useful prognostic indicator.

1979 • 87 citations

Factors controlling the circulating CEA levels in pancreatic cancer: Some clinical correlations

1981 • 85 citations

The demonstration of carcinoembryonic antigen in colorectal carcinoma and colonic polyps using an immunoperoxidase technique

1976 • 82 citations

Carcinoembryonic antigens and related glycoproteins molecular aspects and specificity

1983 • 80 citations

Isolation and structures of the oligosaccharide units of carcinoembryonic antigen.

1983 • 79 citations

Serum alpha-fetoprotein levels in human disease: perspective from a highly specific monoclonal radioimmunoassay.

1984 • 79 citations

Alpha-fetoprotein molecular heterogeneity

1980 • 77 citations

Immunological Study of Polyps of the Colon

1972 • 76 citations

Localization and Concentration of Carcinoembryonic Antigen (CEA) in Gastrointestinal Tumors: Correlation With CEA Levels in Plasma<xref ref-type="fn" rid="fn2">2</xref>

1981 • 76 citations

An immunocytochemical study of T‐cell lymphomas using monoclonal and polyclonal antibodies effective in routinely fixed wax embedded tissues

1986 • 76 citations

Carcinoembryonic antigen in sweat-gland carcinomas

1982 • 75 citations

An optical and ultrastructural study of the localization of carcinoembryonic antigen (CEA) in normal and cancerous human rectocolonic mucosa.

1976 • 74 citations

Carcinoembryonic antigen and other tumor markers in tissue and serum or plasma of patients with primary mammary carcinoma

1978 • 73 citations

Ductal adenocarcinoma of the head of the pancreas: incidence of tumor involvement beyond the Whipple resection line. Histological and immunocytochemical analysis of 37 total pancreatectomy specimens.

1987 • 68 citations

Endodermal sinus (Yolk Sac) tumor elements in testicular germ-cell tumors in adults: Comparison of prospective and retrospective studies

1980 • 67 citations

Monoclonal antibodies to carcinoembryonic antigen: a systematic analysis of antibody specificities by using related normal antigens and evidence for allotypic determinants on carcinoembryonic antigen.

1984 • 67 citations

Hepatocellular carcinoma, adenoma, and focal nodular hyperplasia. Comparative histopathologic study with immunohistochemical parameters.

1986 • 67 citations

Relationship of Serum α-Fetoprotein to the Severity and Duration of Illness in Patients With Viral Hepatitis

1975 • 66 citations

Distribution of tumor-associated antigens in the various histologic components of germ cell tumors of the testis

1981 • 65 citations

A myoepithelial cell line established from a human pleomorphic adenoma arising in minor salivary gland

1980 • 64 citations

TWO CEA AND THREE NCA SPECIES, ALTHOUGH DISTINGUISHABLE BY MONOCLONAL ANTIBODIES, HAVE NEARLY IDENTICAL PEPTIDE PATTERNS

1985 • 63 citations

Yolk sac tumor and alpha-fetoprotein: clinicopathological study of four cases.

1974 • 63 citations

Carcinoembryonic Antigen and Nonspecific Cross-Reacting Antigen in Thyroid Cancer An Immunocytochemical Study Using Polyclonal and Monoclonal Antibodies

1987 • 62 citations

Specificities and binding properties of eight monoclonal antibodies against carcinoembryonic antigen

1982 • 61 citations

Tissue and plasma carcinoembryonic antigen in early breast cancer a prognostic factor

1983 • 61 citations

Immunological heterogeneity of carcinoembryonic antigen: immunohistochemical detection of carcinoembryonic antigen determinants in colonic tumors with monoclonal antibodies.

1983 • 60 citations

Is heterogeneous expression of HLA-DR antigens and CEA along with DNA-profile variations evidence of phenotypic instability and clonal proliferation in human large bowel carcinomas?

1983 • 60 citations

Distribution of epithelial membrane antigen in benign and malignant lesions of the salivary glands

1982 • 59 citations

Epithelial Membrane Antigen: Its Use in the Cytodiagnosis of Malignancy in Serous Effusions

1982 • 58 citations

Monoclonal antibodies for carcinoembryonic antigen (CEA) as a model system: identification of two novel CEA-related antigens in meconium and colorectal carcinoma tissue by Western blots and differential immunoaffinity chromatography.

1985 • 58 citations

Human chorionic gonadotrophin and alpha‐fetoprotein in testicular germ cell tumours: a retrospective immunohistochemical study

1980 • 58 citations

Immunohistochemical Observations of Carcinoembryonic Antigen (CEA) and CEA-related Substances in Normal and Neoplastic Pancreas: Pitfalls and Caveats in CEA Immunohistochemistry

1984 • 57 citations

A highly sensitive method for the demonstration of carcinoembryonic antigen in normal and neoplastic colonic tissue

1978 • 57 citations

Distribution of carcinoembryonic antigens and blood group substances in adenocarcinoma of the colon.

1981 • 56 citations

The dynamics of alpha-fetoprotein and albumin synthesis in human and rat liver during normal ontogeny.

1977 • 56 citations

Production of alpha-fetoprotein and normal serum proteins by xenotransplanted human hepatomas in relation to their growth and morphology.

1979 • 55 citations

Ductal Adenocarcinoma of the Head of the Pancreas

1987 • 55 citations

Primary malignant hepatic tumours in childhood

1985 • 54 citations

Subcellular distribution, synthesis, and release of carcinoembryonic antigen in cultured human colon adenocarcinoma cell lines.

1983 • 54 citations

Carcinoembryonic antigen: immunohistologic identification in invasive and intraepithelial carcinomas of the lung.

1977 • 53 citations

Circulating carcinoembryonic antigen in pancreatic carcinoma

1978 • 51 citations

Immunochemical differences among carcinoembryonic antigen in tumor tissues and related antigens in meconium and adult feces.

1982 • 51 citations

Characterization of monoclonal antibodies to carcinoembryonic antigen with increased tumor specificity.

1986 • 49 citations

Effects of alpha-fetoprotein on murine immune responses. II. Studies on rats.

1977 • 49 citations

Correlation of carcinoembryonic antigen in tissue sections with spread of mammary carcinoma

1978 • 48 citations

Serum alpha fetoprotein heterogeneity as a means of differentiating between primary hepatocellular carcinoma and hepatic secondaries

1984 • 46 citations

Monoclonal antibodies against CEA-related components discriminate between pancreatic duct type carcinomas and nonneoplastic duct lesions as well as nonduct type neoplasias

1986 • 44 citations

Carcinoembryonic antigen (CEA) levels and tumor histology in colon cancer

1975 • 44 citations

Epitopes of carcinoembryonic antigen defined by monoclonal antibodies prepared from mice immunized with purified carcinoembryonic antigen or HCT-8R cells.

1986 • 44 citations

Demonstration of carcinoembryonic antigen (CEA) expression in normal, chronically inflamed, and malignant pancreatic tissue by immunohistochemistry.

1986 • 43 citations

Immunocytochemical evaluation of human prostatic carcinomas for carcinoembryonic antigen, nonspecific cross-reacting antigen, beta-chorionic gonadotrophin, and prostate-specific antigen.

1984 • 41 citations

Localization of alpha-fetoprotein in transplantable murine teratocarcinomas

1973 • 41 citations

A human testicular germ cell tumor with borderline histology between seminoma and embryonal carcinoma secreted beta-human chorionic gonadotropin and alpha-fetoprotein only as a xenograft

1986 • 39 citations

Antigenic subsets of human breast epithelial cells distinguished by monoclonal antibodies.

1984 • 38 citations

Fibrolamellár hepatocellular carcinoma. An immunohistochemical and ultrastructural study

1985 • 37 citations

Presence of carcinoembryonic antigen (CEA) in the normal and inflamed human parotid gland

1981 • 37 citations

Alpha-fetoprotein: its immunofluorescent localization in human fetal liver and hepatoma.

1971 • 36 citations

Relationship of serum CEA levels to tumour size and CEA content in nude mice bearing colonic-tumour xenografts

1981 • 36 citations

CEA and NCA in Benign and Malignant Breast Tumors

1984 • 36 citations

Immunohistochemical detection of alpha-fetoprotein, carcinoembryonic antigen, and ferritin in formalin-paraffin sections from hepatocellular carcinoma.

1985 • 36 citations

Immunohistochemical detection of carcinoembryonic antigen (CEA) in parotid gland carcinomas

1981 • 36 citations

Immunohistochemical distribution of the antigenic determinants detected by monoclonal antibodies to carcinoembryonic antigen.

1984 • 36 citations

Purification of mouse alpha1-fetoprotein and preparation of specific peroxidase conjugates for its cellular localization

1975 • 34 citations

Localisation of CEA, ?-HCG, SP1, and keratin in the tissue of lung carcinomas

1984 • 34 citations

A comparative study of the localization of CEA and NCA2 in cancerous and normal gastrointestinal tissues

1977 • 32 citations

Carcinoembryonic antigen-induced release of a suppressor factor from normal human lymphocytes in vitro.

1984 • 31 citations

Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study

1986 • 31 citations

Carcinoembryonic antigen in primary carcinoid tumors of the lung

1986 • 30 citations

Growth of human colonic adenocarcinoma and development of serum CEA in athymic mice. I: strict correlation of tumour size and mass with serum CEA concentration during logarithmic growth

1982 • 29 citations

Similarities of antisera to casein and epithelial membrane antigen

1982 • 27 citations

Carcinoembryonic antigen in gynecologic patients

1977 • 25 citations

Clinical implications of alpha-fetoprotein in liver cirrhosis: five-year follow-up study.

1980 • 24 citations

CEA positivity in sera and breast tumor tissues obtained from the same patients

1982 • 23 citations

Alpha-fetoprotein: Cellular origin of a biological marker in rat liver under various experimental conditions

1981 • 23 citations

Comparison of CEA distribution in lesions and tumors of salivary glands as determined with monoclonal and polyclonal antibodies

1987 • 22 citations

Carcinoembryonic Antigen A: Chemistry and Biology

1980 • 22 citations

Immunohistochemical Localisation of Alpha-Fetoprotein (AFP) in Germ Cell Tumours: Evidence for AFP Production by Tissues Different from Endodermal Sinus Tumour

1981 • 22 citations

Ultrastructural immunoenzymatic study of alpha-fetoprotein-producing cells in the human fetal liver.

1977 • 20 citations

Tumor markers in parotid gland carcinomas: immunohistochemical investigations.

1983 • 20 citations

Synthesis of Alpha-Fetoprotein (AFP) and cell proliferation in regenerating livers of NMRI mice after partial hepatectomy

1981 • 19 citations

Immunohistochemistry of carcinoembryonic antigen in the small intestine

1978 • 19 citations

Immunohistochemical evidence for the expression of the carcinoembryonic antigen by human thymic epithelial cells in vitro and in neoplastic conditions.

1985 • 18 citations

Characterization of cells in salivary gland lesions by immunohistochemical identification of carcinoembryonic antigens

1985 • 18 citations

An immunohistochemical study of keratin, carcinoembryonic antigen, human chorionic gonadotropin and alpha-fetoprotein in lung cancer.

1985 • 17 citations

Briel Communication : Location by Immunoelectron Microscopy of Carcinoembryonic Antigen on Cultured Adenocarcinoma Cells 2

1975 • 17 citations

Localisation of carcinoembryonic antigen in embryonic and fetal human tissues

1983 • 17 citations

Imunohistochemical Demonstration of Carcinoembryonic Antigen (CEA) in 120 Mammary Carcinomas and its Correlation with Tumor Type, Grading, Staging Plasma-CEA, and Biochemical Receptor Status

1985 • 16 citations

The carcinoembryonic antigen (CEA) in carcinomata of the stomach

1973 • 16 citations

Carcinoembryonic antigen expression and peanut agglutinin binding in primary breast cancer and lymph node metastases; lack of correlation with clinical, histopathological, biochemical and morphometric features

1985 • 16 citations

Monkey antisera with increased specificity to carcinoembryonic antigen (CEA)

1976 • 16 citations

The ultrastructural immunohistochemistry of oncofoetal antigens in large bowel carcinomas

1985 • 14 citations

LOCALIZATION OF α-FETOPROTEIN IN HUMAN AND RAT FETAL LIVERS AN IMMUNOHISTOCHEMICAL METHOD USING HORSERADISH PEROXIDASE

1974 • 14 citations

Relationship between carcinoembryonic antigen and major histocompatibility antigens on cultured human carcinoma cells.

1980 • 14 citations

Carcinoembryonic antigen (CEA) in human colorectal cancers growing subcutaneously in nude mice

1983 • 13 citations

Concanavalin A binding of alpha-fetoprotein in amniotic fluid as an aid in the diagnosis of neural tube defects.

1981 • 13 citations

Serum CEA levels in a human colonic adenocarcinoma (LOVO) xenograft system

1980 • 12 citations

Carcinoembryonic antigen in gynecologic patients. II. Immunohistological expression.

1981 • 12 citations

Structure of the sugar chain of alphafetoprotein purified from a human yolk sac tumor and its reactivity with concanavalin A.

1984 • 12 citations

Histological and Immunohistological Studies on Gastric Mucosa I.The Presence of CEA in Dysplastic Surface Epithelium

1979 • 12 citations

Carcinoembryonic Antigen

1975 • 11 citations

LOCALISATION OF HUMAN α‐FOETOPROTEIN SYNTHESIS IN HEPATOBLASTOMA CELLS BY IMMUNOFLUORESCENCE AND IMMUNOPEROXIDASE METHODS

1974 • 11 citations

Serial carcinoembryonic antigen (CEA) determinations in the management of patients with breast cancer.

1980 • 10 citations

Biochemical and Immunochemical Aspects of Carcinoembryonic Antigen (CEA) and CEA Related Antigens: Current Status and Future Perspectives

1982 • 9 citations

Demonstration of alpha-fetoglobulin in hepatoma tissue by fluorescent antibody technique

1974 • 9 citations

Immunoperoxidase localization of carcinoembryonic antigen in benign and malignant colorectal tumors and related mucosa.

1979 • 8 citations

Carcinoembryonic antigen (CEA) measurements as an aid to management of patients with lung cancer treated by radiotherapy.

1980 • 7 citations

Immunohistochemistry of hepatocellular carcinoma associated with cirrhosis.

1984 • 6 citations

CARCINO‐EMBRYONIC ANTIGEN (CEA) IN GASTRIC ADENOCARCINOMAS

1982 • 6 citations

Differences in the ultrastructural localization of carcinoembryonic antigen in human breast and in colon tumour cells.

1984 • 6 citations

[Alpha 1-fetoprotein and testicular neoplasms].

1980 • 5 citations

The immunobiology of ?-fetoprotein

1980 • 4 citations

Tumoren des männlichen Urogenitalsystems

1986 • 3 citations

Immunhistologische Untersuchungen bei Hodentumoren

1985 • 3 citations

Immunohistologic distribution of CEA defined by human anti-CEA antibody in the serum of a colonic cancer patient

1985 • 3 citations

Differentiation of disease recurrence in various primary malignancies using CEA slope analysis.

1985 • 2 citations

Laboratory Medicine Around the World: Norway

1978 • 2 citations

[Immunohistochemical examination of primary liver cancer (author's transl)].

1981 • 2 citations

Deleted Work

1955 • 0 citations