A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

LPS induction of gene expression in human monocytes

2001 • 2,276 citations

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 • 2,188 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

2003 • 1,137 citations

Nitric oxide and superoxide in inflammation and immune regulation.

2003 • 1,102 citations

Toll-like Receptor 4 Polymorphisms and Atherogenesis

2002 • 1,030 citations

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

2005 • 1,029 citations

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

2002 • 1,028 citations

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

2003 • 1,023 citations

A Fluorometric Assay for the Measurement of Nitrite in Biological Samples

1993 • 1,022 citations

Nitric Oxide in Health and Disease of the Respiratory System

2004 • 874 citations

Relevance of Mutations in the TLR4 Receptor in Patients With Gram-Negative Septic Shock

2002 • 732 citations

Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex

2001 • 652 citations

CORRELATION OF PLASMA INTERLEUKIN 1 LEVELS WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS

1988 • 490 citations

TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β

2003 • 399 citations

Toll‐like receptors, endogenous ligands, and systemic autoimmune disease

2005 • 391 citations

Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia.

1992 • 338 citations

E5531, a Pure Endotoxin Antagonist of High Potency

1995 • 322 citations

Macrophages and post-burn immune dysfunction

2003 • 303 citations

Inhibition of Endotoxin Response by E5564, a Novel Toll-Like Receptor 4-Directed Endotoxin Antagonist

2002 • 290 citations

Macrophages, inflammation, and atherosclerosis

2003 • 278 citations

The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol

2001 • 274 citations

Mammalian Toll-like receptors: to immunity and beyond

2005 • 218 citations

A Synthetic TLR4 Antagonist Has Anti-Inflammatory Effects in Two Murine Models of Inflammatory Bowel Disease

2005 • 217 citations

Adaptor usage and Toll‐like receptor signaling specificity

2005 • 157 citations

Nitric oxide in health and disease

1998 • 153 citations

Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases

2003 • 147 citations

Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium.

1996 • 131 citations

Alterations of the mucosal immune system in inflammatory bowel disease

1996 • 129 citations

Anti-TNF therapies in rheumatoid arthritis, Crohn's disease, sepsis, and myelodysplastic syndromes

2000 • 106 citations

Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.

2002 • 91 citations

Antagonism of <I>in vivo</I> and <I>ex vivo</I> response to endotoxin by E5564, a synthetic lipid A analogue

2002 • 80 citations

Rough and smooth forms of fluorescein‐labelled bacterial endotoxin exhibit CD14/LBP dependent and independent binding that is influencedby endotoxin concentration

2000 • 49 citations

Nitric oxide. A key mediator in sepsis and endotoxaemia?

1997 • 45 citations

The Toll receptor family

2001 • 32 citations

Maintenance of dynamic microvascular function and structure in a rat model of endotoxic shock by blockade of the interleukin-1 receptor.

1995 • 12 citations

Cytosolic protein ubiquitylation in normal and endotoxin stimulated human peripheral blood mononuclear cells

2000 • 12 citations