Buthionine sulfoximine induced growth inhibition in human lung carcinoma cells does not correlate with glutathione depletion

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

A continuous tumor‐cell line from a human lung carcinoma with properties of type II alveolar epithelial cells

1976 • 1,224 citations

The Glutathione Status of Cells

1978 • 1,218 citations

Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion.

1984 • 235 citations

Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation.

1981 • 230 citations

Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione

1987 • 209 citations

Rapid, one step staining procedures for analysis of cellular DNA and protein by single and dual laser flow cytometry

1982 • 168 citations

Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblasts

1986 • 167 citations

The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation.

1985 • 153 citations

Lymphocyte proliferation in glutathione-depleted lymphocytes: direct relationship between glutathione availability and the proliferative response

1989 • 118 citations

Studies on the Subcellular Pathophysiology of Acute Lethal Cell Injury

1974 • 114 citations

Glutathione Depletion, Radiosensitization, and Misonidazole Potentiation in Hypoxic Chinese Hamster Ovary Cells by Buthionine Sulfoximine

1984 • 89 citations

Inhibition of lectin-induced lymphocyte activation by 2-cyclohexene-1-one: decreased intracellular glutathione inhibits an early event in the activation sequence.

1981 • 70 citations

Changes in cellular glutathione content during adriamycin treatment in human ovarian cancer – a possible indicator of chemosensitivity

1989 • 56 citations

Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.

1988 • 55 citations

Buthionine sulfoximine inhibition of cystine uptake and glutathione biosynthesis in human lung carcinoma cells

1985 • 50 citations

Effect of culture conditions on glutathione content in A549 cells

1983 • 48 citations

Glutathione content and growth in A549 human lung carcinoma cells

1990 • 44 citations

Effect of cellular glutathione depletion on cadmium-induced cytotoxicity in human lung carcinoma cells

1987 • 41 citations

Pharmacokinetics of buthionine sulfoximine (NSC 326231) and its effect on melphalan-induced toxicity in mice.

1989 • 25 citations

Enhanced cadmium cytotoxicity in A549 cells with reduced glutathione levels is due to neither enhanced cadmium accumulation nor reduced metallothionein synthesis

1989 • 25 citations

Cadmium cytotoxicity correlates with the changes in glutathione content that occur during the logarithmic growth phase of a549-t27 cells

1990 • 19 citations

Slowing of cell cycle traverse for cells in exponential monolayer cultures placed into plateau-fed and starved medium.

1989 • 14 citations

Alterations in the DNA metabolism of MCa-11 mouse mammary tumor cells grown in vivo and in vitro.

1986 • 12 citations

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