Gene Amplification in Tetrahymena thermophila: Formation of Extrachromosomal Palindromic Genes Coding for rRNA

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

1978 • 1,003 citations

Specific Gene Amplification in Oocytes

1968 • 811 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

[19] In Vitro packaging of λ and cosmid DNA

1979 • 537 citations

A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells

1983 • 485 citations

THE BIOCHEMISTRY OF ANIMAL DEVELOPMENT

1975 • 419 citations

Novel bacteriophage lambda cloning vector.

1980 • 404 citations

Differential synthesis of the genes for ribosomal RNA during amphibian oögenesis.

1968 • 386 citations

Chapter 16 Isolation of Micro- and Macronuclei of Tetrahymena pyriformis

1975 • 385 citations

DOUBLE MINUTES AND HOMOGENEOUSLY STAINING REGIONS: Gene Amplification in Mammalian Cells

1982 • 357 citations

Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster

1980 • 301 citations

The macronuclear ribosomal DNA of Tetrahymena pyriformis is a palindrome

1976 • 224 citations

The diminution of heterochromatic chromosomal segments in Cyclops (Crustacea, Copepoda)

1977 • 193 citations

A single integrated gene for ribosomal RNA in a eucaryote, tetrahymena pyriformis

1977 • 167 citations

Structure of ribosomal DNA in Physarum polycephalum

1976 • 162 citations

Free ribosomal DNA molecules from Tetrahymena pyriformis GL are giant palindromes

1976 • 162 citations

Free Ribosomal RNA Genes in the Macronucleus of Tetrahymena

1974 • 160 citations

Internal sequences are eliminated from genes during macronuclear development in the ciliated protozoan oxytricha nova

1984 • 140 citations

A Small Number of Cistrons for Ribosomal RNA in the Germinal Nucleus of a Eukaryote, Tetrahymena pyriformis

1974 • 118 citations

An irregular satellite sequence is found at the termini of the linear extrachromosomal rDNA in Dictyostelium discoideum

1981 • 107 citations

Repeated hexanucleotide C-C-C-C-A-A is present near free ends of macronuclear DNA of Tetrahymena.

1981 • 104 citations

Gene amplification in Rhynchosciara salivary gland chromosomes.

1982 • 92 citations

Dictyostelium rDNA consists of non-chromosomal palindromic dimers containing 5S and 36S coding regions

1978 • 89 citations

Sequence-specific fragmentation of macronuclear DNA in a holotrichous ciliate

1981 • 84 citations

Tandemly repeated hexanucleotide at tetrahymena rDNA free end is generated from a single copy during development

1982 • 79 citations

Ribosomal RNA gene amplification in tetrahymena may be associated with chromosome breakage and DNA elimination

1981 • 76 citations

A family of inverted repeat sequences and specific single-strand gaps at the termini of the Physarum rDNA palindrome

1980 • 67 citations

Autonomous rDNA molecules containing single copies of the ribosomal RNA genes in the macronucleus of Tetrahymena pyriformis

1974 • 65 citations

OCCURRENCE AND DEVELOPMENTAL SIGNIFICANCE OF GENE AMPLIFICATION

1975 • 35 citations

Unequal excision of complementary strands is involved in the generation of palindromic repetitions of rho− mitochondrial DNA in yeast

1983 • 35 citations

Extrachromosomal rDNA of Tetrahymena thermophila is not a perfect palindrome

1981 • 34 citations

Strong sequence conservation of a 38 bp region near the center of the extrachromosomal rDNA palindrome in differentTetrahymenaspecies

1983 • 19 citations

Sequence homology near the center of the extrachromosomal rDNA palindrome in Tetrahymena

1981 • 15 citations