HT29-MTX/Caco-2 Cocultures as an in Vitro Model for the Intestinal Epithelium: In Vitro–in Vivo Correlation with Permeability Data from Rats and Humans

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

1990 • 820 citations

Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa.

1990 • 565 citations

Human Intestinal H+/Peptide Cotransporter

1995 • 495 citations

Functional biology of intestinal goblet cells

1991 • 454 citations

Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells.

1990 • 414 citations

Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments.

1993 • 306 citations

Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

1988 • 290 citations

Cell cultures as models for drug absorption across the intestinal mucosa.

1991 • 229 citations

Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2

1990 • 224 citations

Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption.

1993 • 207 citations

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans.

1995 • 190 citations

Physiology of the Gastrointestinal Tract (3rd ed)

1995 • 185 citations

Absorption of Peptide and Peptidomimetic Drugs

1994 • 122 citations

The Transport of Vitamin B12 Through Polarized Monolayers of Caco-2 Cells

1990 • 109 citations

Mechanism of intestinal absorption of ranitidine and ondansetron: transport across Caco-2 cell monolayers.

1993 • 95 citations

Dihydrofolate reductase gene amplification-associated shift of differentiation in methotrexate-adapted HT-29 cells.

1991 • 89 citations

Mechanism and kinetics of transcellular transport of a new beta-lactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco-2).

1994 • 78 citations

Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells

1994 • 69 citations

Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): uptake and efflux of phenylalanine

1992 • 66 citations

Uptake and transepithelial transport of the orally absorbed cephalosporin cephalexin, in the human intestinal cell line, Caco-2

1994 • 63 citations

Cefaclor uptake by the proton-dependent dipeptide transport carrier of human intestinal Caco-2 cells and comparison to cephalexin uptake

1992 • 62 citations

Transepithelial transport properties of peptidomimetic thrombin inhibitors in monolayers of a human intestinal cell line (Caco-2) and their correlation to in vivo data.

1995 • 54 citations

Transepithelial transport and metabolism of thyrotropin-releasing hormone (TRH) in monolayers of a human intestinal cell line (Caco-2): evidence for an active transport component?

1994 • 39 citations

Adhesion of human enterotoxigenic Escherichia coli to human mucus secreting HT-29 cell subpopulations in culture.

1994 • 25 citations

Concentration and pH dependency of α-methyldopa absorption in rat intestine

1986 • 25 citations