Mechanism and kinetics of transcellular transport of a new beta-lactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco-2).

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

1989 • 1,027 citations

Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier

1990 • 234 citations

Is intestinal peptide transport energized by a proton gradient?

1985 • 191 citations

Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes.

1992 • 150 citations

H+ coupled uphill transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes.

1986 • 138 citations

Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes.

1993 • 136 citations

Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2

1993 • 116 citations

H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.

1987 • 108 citations

Characterization of the oral absorption of beta-lactam antibiotics. I. Cephalosporins: determination of intrinsic membrane absorption parameters in the rat intestine in situ.

1988 • 84 citations

H+ coupled transport of p.o. cephalosporins via dipeptide carriers in rabbit intestinal brush-border membranes: difference of transport characteristics between cefixime and cephradine.

1988 • 82 citations

Glycyl-<scp>l</scp>-proline transport in rabbit enterocyte basolateral-membrane vesicles

1990 • 80 citations

Intestinal absorption mechanism of amphoteric β-lactam antibiotics I: Comparative absorption and evidence for saturable transport of amino-β-iactam antibiotics by in situ rat small intestine

1981 • 80 citations

H+-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics

1993 • 79 citations

Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells

1994 • 69 citations

Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): uptake and efflux of phenylalanine

1992 • 66 citations

Kinetics and regulation of a polarized Na(+)-H+ exchanger from Caco-2 cells, a human intestinal cell line

1991 • 58 citations

The Caco-2 Cell Monolayers as an Intestinal Metabolism Model: Metabolism of Dipeptide Phe-Pro

1994 • 48 citations

Mechanisms and Kinetics of Uptake and Efflux of L-Methionine in an Intestinal Epithelial Model (Caco-2)

1994 • 47 citations

Comparison of Transport Characteristics of Amino β-Lactam Antibiotics and Dipeptides Across Rat Intestinal Brush Border Membrane

1989 • 47 citations

Transport Characteristics of Cephalosporin Antibiotics Across Intestinal Brush-border Membrane in Man, Rat and Rabbit

1992 • 41 citations

The carbacephems: A new beta-lactam antibiotic class

1992 • 34 citations

Pharmacokinetic profile of loracarbef

1992 • 32 citations

The colon carcinoma cell line Caco-2 contains an H+/K+-ATPase that contributes to intracellular pH regulation

1992 • 31 citations

Effects of Potential Damaging Agents on the Microclimate-pH in the Rat Jejunum

1986 • 28 citations

Intestinal absorption mechanism of amphoteric β-lactam antibiotics II: Michaelis—menten kinetics of cyclacillin absorption and its pharmacokinetic analysis in rats

1981 • 27 citations

Uptake of a Series of Neutral Dipeptides Including <scp>l</scp>-Alanyl-<scp>l</scp>-Alanine, Glycylglycine and Glycylsarcosine by Hamster Jejunum in Vitro

1984 • 17 citations