The Product of the Murine Homolog of the Drosophila extra sex combs Gene Displays Transcriptional Repressor Activity

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Interpreting cDNA sequences: Some insights from studies on translation

1996 • 785 citations

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines.

1989 • 614 citations

Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

1994 • 560 citations

A vector for expressing GAL4(1–147) fusions tn mammalian cells

1989 • 558 citations

Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation.

1991 • 461 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.

1980 • 436 citations

Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein.

1995 • 394 citations

Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression

1978 • 388 citations

GAL4 activates gene expression in mammalian cells

1988 • 355 citations

Heterogeneous Nuclear Ribonucleoprotein K Is a Transcription Factor

1996 • 350 citations

General Initiation Factors for RNA Polymerase II

1993 • 346 citations

The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain

1996 • 344 citations

Functional dissection of the yeast Cyc8–Tupl transcriptional co-repressor complex

1994 • 338 citations

Elements of the Drosophila Bithorax Complex That Mediate Repression by Polycomb Group Products

1993 • 317 citations

Role of chromatin structure in the regulation of transcription by RNA polymerase II

1993 • 298 citations

The eed mutation disrupts anterior mesoderm production in mice

1995 • 284 citations

ROLE OF CHROMATIN STRUCTURE IN THE REGULATION OF TRANSCRIPTION BY RNA POLYMERASE II

1994 • 276 citations

Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters.

1995 • 258 citations

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

1997 • 240 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

GAL4 fusion vectors for expression in yeast or mammalian cells

1992 • 213 citations

The WD repeats of Tup1 interact with the homeo domain protein alpha 2.

1994 • 207 citations

Association of p62, a Multifunctional SH2- and SH3-Domain-Binding Protein, with src Family Tyrosine Kinases, Grb2, and Phospholipase Cγ-1

1995 • 198 citations

Diverse molecular interactions of the hnRNP K protein

1997 • 162 citations

Preparative in vitro mRNA synthesis using SP6 and T7 RNA polymerases

1991 • 155 citations

Transcriptional repression directed by the yeast α2 protein in vitro

1994 • 118 citations

IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism.

1989 • 116 citations

Early role of the esc+ gene product in the determination of segments in Drosophila

1982 • 115 citations

The K Protein Domain That Recruits the Interleukin 1-responsive K Protein Kinase Lies Adjacent to a Cluster of c-Src and Vav SH3-binding Sites

1995 • 112 citations

Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury.

1993 • 96 citations

Chromatin-mediated transcription repression in yeast

1995 • 94 citations

Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex.

1996 • 87 citations

Zik1, a Transcriptional Repressor That Interacts with the Heterogeneous Nuclear Ribonucleoprotein Particle K Protein

1996 • 80 citations

The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family.

1995 • 80 citations

Drosophila choline acetyltransferase uses a non-AUG initiation codon and full length RNA is inefficiently translated.

1990 • 67 citations

A serine/threonine kinase activity is closely associated with a 65-kDa phosphoprotein specifically recognized by the kappa B enhancer element

1991 • 65 citations

Cloning of a Human Homolog of theDrosophila Enhancer of zesteGene (EZH2) That Maps to Chromosome 21q22.2

1996 • 63 citations

Transformation by the Bmi-1 Oncoprotein Correlates with Its Subnuclear Localization but Not Its Transcriptional Suppression Activity

1996 • 60 citations

The Drosophila extra sex combs protein contains WD motifs essential for its function as a repressor of homeotic genes

1995 • 59 citations

Rps3 and rpl16 genes do not overlap in Oenothera mitochondria: GTG as a potential translation initiation codon in plant mitochondria?

1994 • 54 citations

Characterization ofEZH1,a Human Homolog ofDrosophila Enhancer of zestenearBRCA1

1996 • 54 citations

The parainfluenza virus type 1 P/C gene uses a very efficient GUG codon to start its C' protein

1992 • 53 citations

Maximal Expression of Recombinant cDNAs in COS Cells for Use in Expression Cloning

1993 • 47 citations

Description of an IL-1-Responsive Kinase That Phosphorylates the K Protein. Enhancement of Phosphorylation by Selective DNA and RNA Motifs

1995 • 45 citations

Evidence that map (mitogen-activated protein) kinase activation may be a necessary but not sufficient signal for a restrictive subset of responses in IL-1-treated epidermoid cells

1992 • 31 citations

Identification of an inducible 85-kDa nuclear protein kinase.

1993 • 21 citations

Purification of DNA-binding proteins using tandem DNA- affinity column

1993 • 14 citations

A 13 base pair deletion in exon 1 of HPRTIllinois forms a functional GUG initiation codon

1994 • 9 citations