The C-terminal domain of Saccharomyces cerevisiae DNA topoisomerase II.

Genomic sequencing.

1984 • 8,343 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase

1982 • 1,539 citations

DNA topoisomerase II is required at the time of mitosis in yeast

1985 • 747 citations

[40] Immunofluorescence methods for yeast

1991 • 705 citations

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1987 • 691 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

DNA topology and its biological effects

1991 • 612 citations

Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA

1987 • 550 citations

Metaphase chromosome structure

1986 • 538 citations

Localization of topoisomerase II in mitotic chromosomes.

1985 • 501 citations

Mitotic stability of yeast chromosomes: A colony color assay that measures nondisjunction and chromosome loss

1985 • 486 citations

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1985 • 472 citations

Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization.

1984 • 444 citations

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

1987 • 426 citations

DNA topoisomerases: why so many?

1991 • 375 citations

The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication

1992 • 337 citations

Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions.

1989 • 317 citations

Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

1984 • 310 citations

[11] DNA of Saccharomyces cerevisiae

1991 • 308 citations

DNA Topoisomerase II Must Act at Mitosis To Prevent Nondisjunction and Chromosome Breakage

1989 • 302 citations

Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis

1986 • 292 citations

Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast

1992 • 280 citations

Supercoiling of intracellular DNA can occur in eukaryotic cells

1988 • 263 citations

Nicotinic acetylcholine receptor and superfamily of ligand-gated ion channels

1990 • 260 citations

Mechanistic Aspects of DNA Topoisomerases

1986 • 260 citations

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

1989 • 250 citations

Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts.

1993 • 235 citations

The metaphase scaffold is helically folded: Sister chromatids have predominantly opposite helical handedness

1988 • 232 citations

Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

1989 • 206 citations

Purification and characterization of DNA topoisomerase IV in Escherichia coli.

1992 • 194 citations

In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics.

1992 • 181 citations

Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy

1993 • 176 citations

Yeast DNA topoisomerase II is encoded by a single-copy, essential gene

1984 • 175 citations

Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo.

1992 • 170 citations

DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage.

1989 • 167 citations

Tryptic Fragments of the Escherichia coli DNA Gyrase A Protein

1989 • 155 citations

On the coupling between ATP usage and DNA transport by yeast DNA topoisomerase II.

1993 • 153 citations

Cell cycle-dependent phosphorylation of human DNA polymerase alpha.

1991 • 144 citations

Phosphorylation of DNA topoisomerase II in vivo and in total homogenates of Drosophila Kc cells. The role of casein kinase II.

1988 • 126 citations

Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding.

1991 • 124 citations

Anti-topoisomerase II recognizes meiotic chromosome cores

1989 • 118 citations

In vivo phosphorylation of the 170-kDa form of eukaryotic DNA topoisomerase II

1989 • 112 citations

Initiation of Simian Virus 40 DNA Replication Requires the Interaction of a Specific Domain of Human DNA Polymerase α with large T Antigen

1993 • 112 citations

Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeast.

1992 • 105 citations

Appendix II: Alignment of Primary Sequences of DNA Topoisomerases

1994 • 97 citations

Functional dissection of the phosphorylated termini of fission yeast DNA topoisomerase II.

1992 • 94 citations

Activation of mammalian DNA ligase I through phosphorylation by casein kinase II.

1992 • 91 citations

Consequences of topoisomerase II inhibition in early embryogenesis of Drosophila revealed by in vivo confocal laser scanning microscopy

1993 • 89 citations

Regulation of topoisomerase II by phosphorylation: a role for casein kinase II

1993 • 77 citations

A Functional 125-kDa Core Polypeptide of Fission Yeast DNA Topoisomerase II

1991 • 71 citations

Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. I. In vitro studies.

1993 • 66 citations

Growth state and cell cycle dependent phosphorylation of DNA topoisomerase II in Swiss 3T3 cells

1992 • 58 citations

An alkaline sucrose gradient analysis of the mechanism of nuclear DNA synthesis in the yeast Saccharomyces cerevisiae

1978 • 55 citations

A hit-and-run system for targeted genetic manipulations in yeast

1992 • 49 citations

Cell-cycle-dependent phosphorylation and activity of Chinese-hamster ovary topoisomerase II

1993 • 48 citations

Sequences at the C-terminus of the herpes simplex virus type 1 UL30 protein are dispensable for DNA polymerase activity but not for viral origin-dependent DNA replication

1993 • 45 citations

Initiation of simian virus 40 DNA replication requires the interaction of a specific domain of human DNA polymerase alpha with large T antigen.

1993 • 40 citations

Mechanism of assembly of the RNA polymerase II preinitiation complex. Evidence for a functional interaction between the carboxyl-terminal domain of the largest subunit of RNA polymerase II and a high molecular mass form of the TATA factor.

1992 • 40 citations

Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. II. In vivo studies.

1993 • 38 citations

Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors.

1993 • 37 citations

A functional 125-kDa core polypeptide of fission yeast DNA topoisomerase II.

1991 • 35 citations

Two-dimensional agarose gel analysis of simian virus 40 DNA replication intermediates

1991 • 35 citations

Purification and characterization of a nuclear DNA-binding factor complex containing topoisomerase II and chromosome scaffold protein 2.

1993 • 26 citations

Genetic analysis of the gyrase A-like domain of DNA topoisomerase II of Saccharomyces cerevisiae.

1991 • 25 citations

SEQUENCES OF INTEREST: Leucine Zipper in Human DNA Topoisomerase II

1989 • 21 citations

Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors

1993 • 13 citations

Anti-topoisomerase II recognizes meiotic chromosome cores

1990 • 5 citations

[Modification of adenosintriphosphoric acid in cerebral tissue in various functional states of the central nervous system].

1956 • 2 citations