Patch Clamp Techniques for Studying Ionic Channels in Excitable Membranes

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Single-channel currents recorded from membrane of denervated frog muscle fibres

1976 • 2,456 citations

Sodium and calcium channels in bovine chromaffin cells

1982 • 983 citations

Properties of single calcium‐activated potassium channels in cultured rat muscle

1982 • 721 citations

Inward current channels activated by intracellular Ca in cultured cardiac cells

1981 • 687 citations

Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones

1982 • 658 citations

Ca-dependent K channels with large unitary conductance in chromaffin cell membranes

1981 • 647 citations

Relaxation and fluctuations of membrane currents that flow through drug-operated channels

1977 • 630 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

Tight-Seal Whole-Cell Recording

1983 • 605 citations

A receptor for protons in the nerve cell membrane

1980 • 494 citations

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart

1983 • 471 citations

Single Ca2+-activated nonselective cation channels in neuroblastoma

1982 • 446 citations

Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones

1982 • 418 citations

Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture

1981 • 408 citations

Separation of sodium and calcium currents in the somatic membrane of mollusc neurones. With an Appendix by Yu A. Shakhovalov

1977 • 367 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

Properties of single calcium channels in cardiac cell culture

1982 • 342 citations

An improved vaseline gap voltage clamp for skeletal muscle fibers.

1976 • 315 citations

Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells

1983 • 304 citations

Enhanced molecular diffusibility in muscle membrane blebs: release of lateral constraints.

1982 • 255 citations

Calcium currents in internally perfused nerve cell bodies of Limnea stagnalis

1982 • 246 citations

Geometric Parameters of Pipettes and Membrane Patches

1983 • 238 citations

Single channel recordings of K+ currents in squid axons

1980 • 226 citations

Acetylcholine receptor kinetics

1981 • 223 citations

Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches.

1982 • 216 citations

Single-channel currents in isolated patches of plasma membrane from basal surface of pancreatic acini

1982 • 206 citations

Single glutamate-activated channels in locust muscle

1979 • 182 citations

Cholecystokinin activation of single-channel currents is mediated by internal messenger in pancreatic acinar cells

1982 • 177 citations

Sodium channels in cultured cardiac cells.

1983 • 173 citations

Single calcium-dependent potassium channels in clonal anterior pituitary cells

1982 • 173 citations

Replacement of the Protoplasm of a Giant Nerve Fibre with Artificial Solutions

1961 • 164 citations

Single channel currents from excised patches of muscle membrane.

1980 • 157 citations

The gating of single calcium-dependent potassium channels is described by an activation/blockade mechanism

1982 • 155 citations

Curare can open and block ionic channels associated with cholinergic receptors

1982 • 135 citations

Single channel activity associated with the calcium dependent outward current inHelix pomatia

1981 • 134 citations

Single glutamate‐activated channels recorded from locust muscle fibres with perfused patch‐clamp electrodes

1981 • 128 citations

The lowest conductance state of the alamethicin pore

1980 • 123 citations

KCl leakage from microelectrodes and its impact on the membrane parameters of a nonexcitable cell

1983 • 122 citations

Blocking kinetics of the anomalous potassium rectifier of tunicate egg studied by single channel recording

1982 • 119 citations

Calcium ionic channels in electrically excitable membrane

1980 • 112 citations

Studies of single calcium channel currents in rat clonal pituitary cells.

1983 • 107 citations

Single channel currents activated by gamma-aminobutyric acid, muscimol, and (-)-pentobarbital in cultured mouse spinal neurons

1982 • 105 citations

The suction pipette method for internal perfusion and voltage clamp of small excitable cells

1980 • 103 citations

Rapid kinetics of single glutamate-receptor channels

1982 • 87 citations

Single ionic channels observed in tissue-cultured muscle

1979 • 71 citations

Single channel potassium currents of the anomalous rectifier

1981 • 57 citations

Are Ions Involved in the Gating of Calcium Channels?

1982 • 52 citations

What is the mechanism of the calcium influx to pancreatic acinar cells evoked by secretagogues?

1983 • 52 citations

Kinetics of acetylcholine activated ion channels in chick ciliary ganglion neurones grown in tissue culture

1984 • 47 citations

Bursts of Openings in Transmitter-Activated Ion Channels

1983 • 47 citations

Acetylcholine-induced ionic channels in rat skeletal muscle.

1978 • 45 citations

Single postsynaptic channel currents in tissue cultured muscle

1979 • 33 citations

Experimental Approaches Used to Examine Single Glutamate-Receptor Ion Channels in Locust Muscle Fibers

1983 • 17 citations

COMMUNICATIONS

1981 • 16 citations

Cholecystokinin and Acetylcholine Activation of Single-Channel Currents via Second Messenger in Pancreatic Acinar Cells

1983 • 14 citations