Reperfusion revisited: Beyond TIMI3 flow

An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction

1993 • 3,911 citations

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

1985 • 3,610 citations

The Thrombolysis in Myocardial Infarction (TIMI) Trial

1985 • 3,078 citations

The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

1974 • 1,804 citations

Prognostic Significance of Microvascular Obstruction by Magnetic Resonance Imaging in Patients With Acute Myocardial Infarction

1998 • 1,364 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

TRIAL OF TISSUE PLASMINOGEN ACTIVATOR FOR MORTALITY REDUCTION IN ACUTE MYOCARDIAL INFARCTION

1988 • 1,161 citations

Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction.

1992 • 1,068 citations

Clinical Implications of the ‘No Reflow’ Phenomenon

1996 • 1,031 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

A Clinical Trial Comparing Primary Coronary Angioplasty with Tissue Plasminogen Activator for Acute Myocardial Infarction

1997 • 908 citations

Prehospital-Initiated vs Hospital-Initiated Thrombolytic Therapy

1993 • 673 citations

Effect of Glycoprotein IIb/IIIa Receptor Blockade on Recovery of Coronary Flow and Left Ventricular Function After the Placement of Coronary-Artery Stents in Acute Myocardial Infarction

1998 • 545 citations

Incidence and treatment of 'no-reflow' after percutaneous coronary intervention.

1994 • 520 citations

HOME OR AWAY?

1964 • 508 citations

Role of leukocytes in response to acute myocardial ischemia and reflow in dogs

1986 • 507 citations

Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?

1980 • 488 citations

Link Between the Angiographic Substudy and Mortality Outcomes in a Large Randomized Trial of Myocardial Reperfusion

1995 • 486 citations

Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow.

1989 • 468 citations

Myocardial Perfusion Patterns Related to Thrombolysis in Myocardial Infarction Perfusion Grades After Coronary Angioplasty in Patients With Acute Anterior Wall Myocardial Infarction

1996 • 443 citations

Combined Accelerated Tissue-Plasminogen Activator and Platelet Glycoprotein IIb/IIIa Integrin Receptor Blockade With Integrilin in Acute Myocardial Infarction

1997 • 383 citations

Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon.

1987 • 378 citations

Microvascular integrity indicates myocellular viability in patients with recent myocardial infarction. New insights using myocardial contrast echocardiography.

1994 • 377 citations

Studies of experimental coronary artery reperfusion. Effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage.

1983 • 363 citations

Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction?

1993 • 344 citations

Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.

1985 • 324 citations

Profound inhibition of platelet aggregation with monoclonal antibody 7E3 Fab thrombolytic therapy

1993 • 308 citations

Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion.

1991 • 302 citations

TIMI perfusion grade 3 but not grade 2 results in improved outcome after thrombolysis for myocardial infarction. Ventriculographic, enzymatic, and electrocardiographic evidence from the TEAM-3 Study.

1993 • 289 citations

Features and outcome of no-reflow after percutaneous coronary intervention

1995 • 286 citations

Impact of early perfusion status of the infarct-related artery on short-term mortality after thrombolysis for acute myocardial infarction: Retrospective analysis of four german multicenter studies

1993 • 268 citations

Beneficial Effect of Intracoronary Verapamil on Microvascular and Myocardial Salvage in Patients With Acute Myocardial Infarction

1997 • 257 citations

Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction.

1994 • 256 citations

Alternation in the Coronary Blood Flow Velocity Pattern in Patients With No Reflow and Reperfused Acute Myocardial Infarction

1996 • 240 citations

Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation.

1998 • 237 citations

Does thrombolysis in myocardial infarction (TIMI) perfusion grade 2 represent a mostly patent artery or a mostly occluded artery? Enzymatic and electrocardiographic evidence from the TEAM-2 study

1992 • 236 citations

Improved thrombolysis in acute myocardial infarction with front-loaded administration of alteplase: Results of the rt-PA-APSAC patency study (TAPS)

1992 • 233 citations

"Reperfusion injury" by oxygen-derived free radicals? Effect of superoxide dismutase plus catalase, given at the time of reperfusion, on myocardial infarct size, contractile function, coronary microvasculature, and regional myocardial blood flow.

1989 • 209 citations

A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen activator (activase) in acute myocardial infarction

1987 • 186 citations

Scintigraphic evidence of the “No reflow” phenomenon in human beings after coronary thrombolysis

1985 • 183 citations

EFFECT OF INTRAVENOUS APSAC ON MORTALITY AFTER ACUTE MYOCARDIAL INFARCTION: PRELIMINARY REPORT OF A PLACEBO-CONTROLLED CLINICAL TRIAL

1988 • 167 citations

Prediction of short- and intermediate-term prognoses of patients with acute myocardial infarction using myocardial contrast echocardiography one day after recanalization

1998 • 164 citations

Temporal Changes in Myocardial Perfusion Patterns in Patients With Reperfused Anterior Wall Myocardial Infarction

1995 • 148 citations

Myocardial Contrast Echocardiography Versus Dobutamine Echocardiography for Predicting Functional Recovery After Acute Myocardial Infarction Treated With Primary Coronary Angioplasty

1996 • 144 citations

Myocardial neutrophil accumulation during reperfusion after reversible or irreversible ischemic injury

1988 • 142 citations

Progressive failure of coronary flow during reperfusion of myocardial infarction: Documentation of the no reflow phenomenon with positron emission tomography

1990 • 135 citations

Assessment of “microvascular no-reflow phenomenon” using technetium-99m macroaggregated albumin scintigraphy in patients with acute myocardial infarction

1998 • 134 citations

Benefit of Thrombolytic Therapy Is Sustained Throughout Five Years and Is Related to TIMI Perfusion Grade 3 But Not Grade 2 Flow at Discharge

1995 • 122 citations

Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor lamifiban: results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) Trial

1998 • 118 citations

Local effects of acute cellular injury on regional myocardial blood flow.

1976 • 103 citations

The relevance of platelet and fibrin thromboembolism of the coronary microcirculation, with special reference to sudden cardiac death.

1980 • 99 citations

Salutary effect of adjunctive intracoronary nicorandil administration on restoration of myocardial blood flow and functional improvement in patients with acute myocardial infarction

1997 • 99 citations

Evidence for decreased coronary flow reserve in viable postischemic myocardium.

1990 • 96 citations

Analysis of microvascular integrity, contractile reserve, and myocardial viability after acute myocardial infarction by dobutamine echocardiography and myocardial contrast echocardiography

1996 • 96 citations

Platelet accumulation in regions of low blood flow during the postischemic period.

1985 • 94 citations

Intravenous Fluosol in the treatment of acute myocardial infarction. Results of the Thrombolysis and Angioplasty in Myocardial Infarction 9 Trial. TAMI 9 Research Group.

1994 • 94 citations

Combined tissue-type plasminogen activator and prostacyclin therapy for acute myocardial infarction

1989 • 94 citations

Significance of a coronary artery with Thrombolysis in Myocardial infarction grade 2 flow “patency” (outcome in the Thrombolysis and Angioplasty in Myocardial Infarction trials)

1995 • 92 citations

Recovery of Myocardial Perfusion in Acute Myocardial Infarction After Successful Balloon Angioplasty and Stent Placement in the Infarct-Related Coronary Artery

1997 • 81 citations

Endogenous adenosine inhibits P-selectin-dependent formation of coronary thromboemboli during hypoperfusion in dogs.

1998 • 79 citations

Identification of myocardial reperfusion with echo planar magnetic resonance imaging. Discrimination between occlusive and reperfused infarctions.

1994 • 76 citations

Attenuation of the no-reflow phenomenon after coronary angioplasty for acute myocardial infarction with intracoronary papaverine

1996 • 71 citations

Early changes in myocardial perfusion patterns after myocardial infarction: relation with contractile reserve and functional recovery

1998 • 64 citations

Distinguishing viable from infarcted myocardium after experimental ischemia and reperfusion by using nuclear magnetic resonance imaging

1990 • 60 citations

Effect of intravenous APSAC on mortality after acute myocardial infarction: preliminary report of a placebo-controlled clinical trial. AIMS Trial Study Group.

1988 • 59 citations

Reperfusion and irreversible myocardial injury: identification with a nonionic MR imaging contrast medium.

1992 • 58 citations

Microvascular injury in reperfused infarcted myocardium: noninvasive assessment with contrast-enhanced echoplanar magnetic resonance imaging 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.

1998 • 57 citations

Histologic confirmation of microvascular hyperpermeability to macromolecular MR contrast medium in reperfused myocardial infarction

1998 • 57 citations

Rapid reversal of no-reflow using abciximab after coronary device intervention

1997 • 55 citations

Effects of prostacyclin, indomethacin, and heparin on cerebral blood flow and platelet adhesion after multifocal ischemia of canine brain.

1988 • 54 citations

The temporal pattern of recovery of myocardial perfusion and metabolism delineated by positron emission tomography after coronary thrombolysis.

1987 • 49 citations

Evaluation of dynamic changes in microvascular flow during ischemia-reperfusion by myocardial contrast echocardiography

1998 • 46 citations

Transient platelet accumulation in the rat brain after common carotid artery thrombosis. An 111In-labeled platelet study.

1993 • 45 citations

Functional role of microvascular integrity in patients with infarct-related artery patency after acute myocardial infarction

1997 • 42 citations

Selective platelet deposition during focal cerebral ischemia in cats.

1989 • 22 citations

Noninvasive assessment of no-reflow phenomenon in a canine model of reperfused infarction by contrast-enhanced magnetic resonance imaging

1995 • 21 citations

Distal coronary flow velocity immediately after direct angioplasty for acute myocardial infarction

1996 • 18 citations

Pathogenesis and morphogenesis of microcirculatory disorders in myocardial infarction. Clinical and ultrastructural examination.

1996 • 6 citations

Detection of no-reflow zones using intra venous ultrasound contrast and intermittent harmonic imaging in patients with acute myocardial infarction and angiographically successful recanalization

1997 • 5 citations