The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

2000 • 2,384 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

C-type lectin receptors on dendritic cells and langerhans cells

2002 • 824 citations

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 • 777 citations

Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR

2001 • 659 citations

The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells

2002 • 613 citations

C-type lectin-like domains

1999 • 609 citations

Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni.

1991 • 542 citations

Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.

1990 • 501 citations

DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking

2000 • 498 citations

A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR

2001 • 497 citations

Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.

1992 • 381 citations

Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes

1992 • 350 citations

Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum.

1985 • 306 citations

Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets.

1994 • 299 citations

CD8− Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development

2001 • 287 citations

Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways

2001 • 277 citations

Carbohydrates of human immunodeficiency virus. Structures of oligosaccharides linked to the envelope glycoprotein 120.

1988 • 269 citations

Human Protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide

1994 • 233 citations

Lacto-N-fucopentaose III Found on Schitosoma mansoni Egg Antigens Functions as Adjuvant for Proteins by Inducing Th2-Type Response

2001 • 212 citations

Identification of Different Binding Sites in the Dendritic Cell-specific Receptor DC-SIGN for Intercellular Adhesion Molecule 3 and HIV-1

2002 • 184 citations

The Schistosome Oligosaccharide Lacto-N-neotetraose Expands Gr1+ Cells That Secrete Anti-inflammatory Cytokines and Inhibit Proliferation of Naive CD4+ Cells: A Potential Mechanism for Immune Polarization in Helminth Infections

2001 • 163 citations

Various stages of Schistosoma express Lewisx, LacdiNAc, GalNAc 1-4 (Fuc 1-3)GlcNAc and GalNAc 1-4(Fuc 1-2Fuc 1-3)GlcNAc carbohydrate epitopes: detection with monoclonal antibodies that are characterized by enzymatically synthesized neoglycoproteins

2000 • 135 citations

The Immunologically Reactive O‐Linked Polysaccharide Chains Derived from Circulating Cathodic Antigen Isolated from the Human Blood Fluke Schistosoma Mansoni have Lewis x as Repeating Unit

1994 • 128 citations

Structural mapping of the glycans from the egg glycoproteins of Schistosoma mansoni and Schistosoma japonicum: identification of novel core structures and terminal sequences

1997 • 126 citations

A Unique Multifucosylated −3GalNAcβ1→4GlcNAcβ1→3Galα1- Motif Constitutes the Repeating Unit of the Complex O-Glycans Derived from the Cercarial Glycocalyx of Schistosoma mansoni

1995 • 125 citations

Evidence of a T helper type 2 activation in human schistosomiasis

1996 • 123 citations

The human blood fluke Schistosoma mansoni synthesizes glycoproteins containing the Lewis X antigen.

1992 • 114 citations

Carbohydrates of human immunodeficiency virus.

1992 • 104 citations

High Frequency of Adhesion Defects in B-Lineage Acute Lymphoblastic Leukemia

1999 • 103 citations

Antibodies to Glycans Dominate the Host Response to Schistosome Larvae and Eggs: Is Their Role Protective or Subversive?

2001 • 100 citations

Schistosome glycoconjugates

1999 • 92 citations

Glycobiology of schistosomiasis

1996 • 90 citations

Schistosoma mansoni cercarial glycolipids are dominated by Lewis X and pseudo-Lewis Y structures

2000 • 83 citations

Structural characterization of the N-glycans of Dictyocaulus viviparus: discovery of the Lewisx structure in a nematode

2000 • 82 citations

Antibody Responses to the Fucosylated LacdiNAc Glycan Antigen in Schistosoma mansoni-Infected Mice and Expression of the Glycan among Schistosomes

2000 • 77 citations

Expression of Lex antigen in Schistosoma japonicum and S.haematobium and immune responses to Lex in infected animals: Lack of Lex expression in other trematodes and nematodes

1998 • 76 citations

Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera ofSchistosoma-Infected Individuals Determined by Surface Plasmon Resonance

2001 • 75 citations

Schistosoma mansoniInfection in Humans and Primates Induces Cytolytic Antibodies to Surface LexDeterminants on Myeloid Cells

1996 • 73 citations

Lewisx-containing oligosaccharide attenuates schistosome egg antigen-induced immune depression in human schistosomiasis

2000 • 71 citations

Mice infected with Schistosoma mansoni generate antibodies to LacdiNAc (GalNAc 1->4GlcNAc) determinants

1999 • 65 citations

Characteristic structural features of schistosome cercarial N-glycans: expression of Lewis X and core xylosylation

2001 • 62 citations

Schistosoma mansoni excretory circulating cathodic antigen shares Lewis- x epitopes with a human granulocyte surface antigen and evokes host antibodies mediating complement-dependent lysis of granulocytes

1996 • 56 citations

Schistosoma mansoni excretory circulating cathodic antigen shares Lewis- x epitopes with a human granulocyte surface antigen and evokes host antibodies mediating complement-dependent lysis of granulocytes

1996 • 53 citations

Rodents infected with Schistosoma mansoni produce cytolytic IgG and IgM antibodies to the Lewis x antigen

1997 • 40 citations

Schistosomal granuloma modulation. II. Specific immunogenic carbohydrates can modulate schistosome-egg-antigen-induced hepatic granuloma formation

1999 • 37 citations

Regulation of schistosome egg granuloma formation: host-soluble L-selectin enters tissue-trapped eggs and binds to carbohydrate antigens on surface membranes of miracidia

1996 • 31 citations

Structural study of N‐linked oligosaccharides of human intercellular adhesion molecule‐3 (CD50)

2001 • 23 citations

Schistosomal granuloma modulation

1999 • 14 citations

High Frequency of Adhesion Defects in B-Lineage Acute Lymphoblastic Leukemia

1999 • 11 citations