Superoxide Anion May Trigger DNA Strand Breaks in Human Granulocytes by Acting at a Membrane Target ^a

Oxygen Radicals and Human Disease

1987 • 1,854 citations

The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1986 • 665 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation.

1981 • 448 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

Detection of superoxide generated by endothelial cells.

1984 • 398 citations

Permeation of the erythrocyte stroma by superoxide radical

1978 • 367 citations

Superoxide anion permeability of phospholipid membranes and chloroplast thylakoids

1983 • 302 citations

DNA Strand Breakage in Human Leukocytes Exposed to a Tumor Promoter, Phorbol Myristate Acetate

1982 • 255 citations

The production of DNA strand breaks in human leukocytes by superoxide anion may involve a metabolic process.

1985 • 124 citations

DNA strand breaks in human leukocytes induced by superoxide anion, hydrogen peroxide and tumor promoters are repaired slowly compared to breaks induced by ionizing radiation

1986 • 123 citations

Superoxide production by polymorphonuclear leukocytes

1986 • 117 citations

Tumor suppressors: Recessive mutations that lead to cancer

1988 • 115 citations

Neutrophil-mediated methemoglobin formation in the erythrocyte. The role of superoxide and hydrogen peroxide.

1982 • 105 citations

Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Characterization of the membrane-associated component.

1987 • 73 citations

Macrophage-derived superoxide-generating NADPH oxidase in an amphiphile-activated, cell-free system; partial purification of the cytosolic component and evidence that it may contain the NADPH binding site

1988 • 36 citations

Oxidative Stress in Human Neutrophilic Granulocytes: Host Defence and Self-Defence

1985 • 30 citations

A superoxide anion induced DNA strand-break metabolic pathway in human leukocytes: effects of vanadate

1988 • 28 citations

The release of superoxide anion from granulocytes: Effect of inhibitors of anion permeability

1979 • 23 citations

Failure of Phorbol Myristate Acetate to Damage DNA in Leukocytes from Patients with Chronic Granulomatous Disease

1982 • 13 citations

In vivo induction of tumor variants by phorbol 12-myristate 13-acetate

1987 • 3 citations