Why Most Published Research Findings Are False

Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>

2000 • 18,725 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

2001 • 5,358 citations

Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement

1999 • 4,736 citations

The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials

2001 • 2,497 citations

Searching for genetic determinants in the new millennium

2000 • 1,878 citations

Replication validity of genetic association studies

2001 • 1,845 citations

Empirical Evidence for Selective Reporting of Outcomes in Randomized Trials

2004 • 1,728 citations

Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

2004 • 1,720 citations

A Comparison of Results of Meta-analyses of Randomized Control Trials and Recommendations of Clinical Experts

1992 • 1,451 citations

Sifting the evidence---what's wrong with significance tests? Another comment on the role of statistical methods

2001 • 1,398 citations

Contradicted and Initially Stronger Effects in Highly Cited Clinical Research

2005 • 1,394 citations

What do we mean by validating a prognostic model?

2000 • 1,378 citations

Better Reporting of Harms in Randomized Trials: An Extension of the CONSORT Statement

2004 • 1,377 citations

Methods in Observational Epidemiology

1986 • 1,345 citations

Methods in observational epidemiology

1987 • 1,284 citations

Problems of reporting genetic associations with complex outcomes

2003 • 1,221 citations

Prediction of cancer outcome with microarrays: a multiple random validation strategy

2005 • 982 citations

A STATISTICAL PARADOX

1957 • 947 citations

Unpublished rating scales: A major source of bias in randomised controlled trials of treatments for schizophrenia

2000 • 873 citations

Epidemiology Faces Its Limits

1995 • 857 citations

Why do we need some large, simple randomized trials?

1984 • 692 citations

Failing the Public Health — Rofecoxib, Merck, and the FDA

2004 • 598 citations

When are observational studies as credible as randomised trials?

2004 • 518 citations

Rules of evidence for cancer molecular-marker discovery and validation

2004 • 495 citations

Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence?

2004 • 429 citations

Early extreme contradictory estimates may appear in published research: The Proteus phenomenon in molecular genetics research and randomized trials

2005 • 329 citations

Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment

2003 • 326 citations

A comment on D. V. Lindley's statistical paradox

1957 • 304 citations

Genetic associations: false or true?

2003 • 281 citations

A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction

1992 • 206 citations

Comparison of Methods for Estimating the Number of True Null Hypotheses in Multiplicity Testing

2003 • 110 citations

Scientific Journals and Their Authors’ Financial Interests: A Pilot Study

1998 • 107 citations

Two cheers for P-values?

2001 • 100 citations

Transfer of Technology From Statistical Journals to the Biomedical Literature

1994 • 91 citations

Reporting of conflicts of interest in guidelines of preventive and therapeutic interventions

2001 • 62 citations

Comparison of Results

1995 • 51 citations

Transfer of technology from statistical journals to the biomedical literature. Past trends and future predictions

1994 • 20 citations